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Patent Digest: Spring 2016

Innovations in immune-stimulating and slippery surface materials, and soft robotic exosuit technology

To realize its overarching goal to invent and commercialize disruptive solutions for healthcare, energy, architecture, robotics, and manufacturing, the Wyss Institute is creating a patent portfolio in relevant areas that are or can become an essential basis for specific business development and commercialization efforts. To learn more about these innovations, contact our Business Development Team.

The Wyss Institute’s U.S. patents issued between April and June 2016 are as follows:

Controlled delivery of TLR agonists in structural polymeric devices. Credit: Harvard University

Controlled delivery of TLR agonists in structural polymeric devices

Controlled delivery of TLR agonists in structural polymeric devices

U.S. Patent 9,370,558 (June 21, 2016)

Omar Abdel-Rahman Ali, Glenn Dranoff, and David J. Mooney

Abstract: The present invention comprises compositions, methods, and devices for creating an stimulating an antigen-specific dendritic cell immune response. Devices and methods provide prophylactic and therapeutic immunity to subjects against cancer and infectious agents.

Slippery surfaces with high pressure stability, optical transparency, and self-healing characteristics

U.S. Patent 9,353,646 (May 31, 2016)

Joanna Aizenberg, Michael Aizenberg, Sung Hoon Kang, Philseok Kim, and Tak Sing Wong

Abstract: The present disclosure describes a strategy to create self-healing, slippery liquid-infused porous surfaces (SLIPS). Roughened (e.g., porous) surfaces can be utilized to lock in place a lubricating fluid, referred to herein as Liquid B to repel a wide range of materials, referred to herein as Object A (Solid A or Liquid A). SLIPS outperforms other conventional surfaces in its capability to repel various simple and complex liquids (water, hydrocarbons, crude oil and blood), maintain low-contact-angle hysteresis (<2.5°), quickly restore liquid-repellency after physical damage (within 0.1-1 s), resist ice, microorganisms and insects adhesion, and function at high pressures (up to at least 690 atm). Some exemplary application where SLIPS will be useful include energy-efficient fluid handling and transportation, optical sensing, medicine, and as self-cleaning, and anti-fouling materials operating in extreme environments.

Soft exosuit for assistance with human motion. Credit: Harvard University.

Soft exosuit for assistance with human motion

U.S. Patent 9,351,900 (May 31, 2016)

Conor Walsh, Alan Thomas Asbeck, Ignacio Galiana Bujanda, Ye Ding, Robert Joseph Dyer, Arnar Freyr Larusson, Brendan Thomas Quinlivan, Kai Schmidt, Diana Wagner, and Michael Wehner

Abstract: In at least one aspect, there is provided a system for generating force about one or more joints including a soft exosuit having a plurality of anchor elements and at least one connection element disposed between the plurality of anchor elements. The system also includes at least one sensor to determine a force the at least one connection element or at least one of the plurality of anchor elements and to output signals relating to the force, at least one actuator configured to change a tension in the soft exosuit and at least one controller configured to receive the signals output from the at least one sensor and actuate the at least one actuator responsive to the received signals.

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