Search Results for “brain”

December 24, 2025
Alzheimer's & Dementia
Transport target expression, a biomarker of brain shuttle fusion drug uptake, shows minimal influence of brain region, disease state, gender, and age, yet reveals significant individual variation

Ana R. Santa‐Maria, Sanjid Shahriar
May 14, 2026
Philosophical Transactions of the Royal Society A
Brains and where else? Mapping theories of consciousness to unconventional embodiments

Nicolas Rouleau; Michael Levin
November 4, 2023
iScience
Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain

Santosh Manicka, Vaibhav P Pai, Michael Levin
April 16, 2025
Bioengineering & Translational Medicine
Cell therapies against brain tumors: Clinical development and emerging prospects

Tatsuya Fukuta, Suyog Shaha, Andres da Silva-Candal, Zongmin Zhao, Samir Mitragotri
January 16, 2026
iScience
A human blood-brain barrier model reveals pericytes as critical regulators of viral neuroinvasion

Alexsia Richards, Andrew Khalil, Punam Bisht, Troy W Whitfield, Xinlei Gao, David Mooney, Lee Gehrke, Rudolf Jaenisch
November 5, 2025
Nature Biotechnology
A nonsurgical brain implant enabled through a cell-electronics hybrid for focal neuromodulation

Shubham Yadav, Ray X. Lee, Shivam N. Kajale, Baju Joy, Monochura Saha, Preet Patel, Loey Bull, Sarah Cao, Samir Mitragotri, David Bono & Deblina Sarkar
February 4, 2020
npj Regenerative Medicine
An in vivo brain-bacteria interface: the developing brain as a key regulator of innate immunity

Celia Herrera-Rincon, Jean-Francois Paré, Christopher J. Martyniuk, Sophia K. Jannetty, Christina Harrison, Alina Fischer, Alexandre Dinis, Vishal Keshari, Richard Novak & Michael Levin
March 17, 2025
Journal of Extracellular Vesicles
Toward Identification of Markers for Brain-Derived Extracellular Vesicles in Cerebrospinal Fluid: A Large-Scale, Unbiased Analysis Using Proximity Extension Assays

Maia Norman, Adnan Shami-shah, Sydney C. D'Amaddio, Benjamin G. Travis, Dmitry Ter-Ovanesyan, Tyler J. Dougan, David R. Walt
March 20, 2020
Integrative Biology
Human brain microvascular endothelial cell pairs model tissue-level blood-brain barrier function

Blakely B O’Connor, Thomas Grevesse, John F Zimmerman, Herdeline Ann M Ardoña, Jorge A Jimenez, Dimitrios Bitounis, Philip Demokritou, Kevin Kit Parker
September 9, 2024
Frontiers in Medical Technology
Structural brain preservation: a potential bridge to future medical technologies

Andrew T McKenzie, Ariel Zeleznikow-Johnston, Jordan S Sparks, Oge Nnadi, John Smart, Keith Wiley, Michael A Cerullo, Aschwin de Wolf, Francesca Minerva, Ramón Risco, George M Church, João Pedro de Magalhães, Emil F Kendziorra
October 24, 2024
Nature Cell Biology
Differential stiffness between brain vasculature and parenchyma promotes metastatic infiltration through vessel co-option

Marina Uroz, Amy E. Stoddard, Bryan P. Sutherland, Olivia Courbot, Roger Oria, Linqing Li, Cara R. Ravasio, Mai T. Ngo, Jinling Yang, Juliann B. Tefft, Jeroen Eyckmans, Xue Han, Alberto Elosegui-Artola, Valerie M. Weaver & Christopher S. Chen
December 12, 2018
Bioengineering & Translational Medicine
A microfluidic model of human brain (μHuB) for assessment of blood brain barrier

Tyler D. Brown, Maksymilian Nowak, Alexandra V. Bayles, Balabhaskar Prabhakarpandian, Pankaj Karande, Joerg Lahann, Matthew E. Helgeson, Samir Mitragotri
September 14, 2020
ACS Biomaterials Science & Engineering
Effect of Nanoparticle Composition, Size, Shape, and Stiffness on Penetration Across the Blood-Brain Barrier

Tyler D. Brown, Nahal Habibi, Debra Wu, Joerg Lahann, and Samir Mitragotri
August 13, 2025
Advanced Science
Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome

Magdalena Litman, Sara Azarpeykan, Rebecca J Hood, Kristy Martin, Debbie Pepperall, Daniel Omileke, Fern Williams, Oktay Uzun, Deen Bhatta, Yuen K Yong, Alex Chan, Nicholas Hough, Sarah Johnson, Pablo Garcia Bermejo, Ferdinand Miteff, Carlos Garcia Esperon, Yvonne Couch, Alastair M Buchan, Neil J Spratt, Netanel Korin, Donald E Ingber, Daniel J Beard
December 15, 2019
Bioengineering & Translational Medicine
Size, Shape, and Flexibility Influence Nanoparticle Transport Across Brain Endothelium Under Flow

Maksymilian Nowak, Tyler D Brown, Adam Graham, Matthew E Helgeson, Samir Mitragotri
May 26, 2020
Frontiers in Cellular Neuroscience
HCN2 Channel-Induced Rescue of Brain Teratogenesis via Local and Long-Range Bioelectric Repair

Vaibhav P. Pai, Javier Cervera, Salvador Mafe, Valerie Willocq, Emma K. Lederer and Michael Levin
January 3, 2024
Science Translational Medicine
Preclinical characterization of macrophage-adhering gadolinium micropatches for MRI contrast after traumatic brain injury in pigs

LILY LI-WEN WANG, YONGSHENG GAO, VINEETH CHANDRAN SUJA, MASEN L. BOUCHER, SUYOG SHAHA, NEHA KAPATE, RICK LIAO, TAO SUN, NINAD KUMBHOJKAR, SUPRIYA PRAKASH, JOHN R. CLEGG, KAITLYN WARREN, MORGAN JANES, KYUNG SOO PARK, MICHAEL DUNNE, BOLU ILELABOY, ANDREW LU, SOLOMINA DARKO, CAMILO JAIMES, REBEKAH MANNIX, AND SAMIR MITRAGOTRI
August 29, 2022
Nature Biomedical Engineering
Revealing nanostructures in brain tissue via protein decrowding by iterative expansion microscopy

Deblina Sarkar, Jinyoung Kang, Asmamaw T. Wassie, Margaret E. Schroeder, Zhuyu Peng, Tyler B. Tarr, Ai-Hui Tang, Emily D. Niederst, Jennie Z. Young, Hanquan Su, Demian Park, Peng Yin, Li-Huei Tsai, Thomas A. Blanpied & Edward S. Boyden
August 17, 2020
Biomolecules
A 3D Tissue Model of Traumatic Brain Injury with Excitotoxicity That Is Inhibited by Chronic Exposure to Gabapentinoids

Nicolas Rouleau, Mattia Bonzanni, Joshua D Erndt-Marino, Katja Sievert, Camila G Ramirez, William Rusk, Michael Levin, David L Kaplan
November 29, 2024
Cells
Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer’s Disease and Autoimmune Diseases

Jonathan Sundstrom, Emma Vanderleeden, Nathaniel J Barton, Sambra D Redick, Pepper Dawes, Liam F Murray, Meagan N Olson, Khanh Tran, Samantha M Chigas, Adrian R Orszulak, George M Church, Benjamin Readhead, Hyung Suk Oh, David M Harlan, David M Knipe, Jennifer P Wang, Yingleong Chan, Elaine T Lim
December 13, 2023
PNAS Nexus
Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury

Neha Kapate, Rick Liao, Ryan Luke Sodemann, Tawny Stinson, Supriya Prakash, Ninad Kumbhojkar, Vineeth Chandran Suja, Lily Li-Wen Wang, Mikayla Flanz, Rohan Rajeev, Dania Villafuerte, Suyog Shaha, Morgan Janes, Kyung Soo Park, Michael Dunne, Bryan Golemb, Alexander Hone, Kolade Adebowale, John Clegg, Andrea Slate, Declan McGuone, Beth Costine-Bartell, Samir Mitragotri
September 3, 2020
ACS Nano
Tumor-Derived Extracellular Vesicles Breach the Intact Blood-Brain Barrier via Transcytosis

Golnaz Morad, Christopher V. Carman, Elliott J. Hagedorn, Julie R. Perlin, Leonard I. Zon, Nur Mustafaoglu, Tae-Eun Park, Donald E. Ingber, Cassandra C. Daisy, and Marsha A. Moses
December 28, 2016
Journal of Neurophysiology
Neurons derived from different brain regions are inherently different in vitro: A novel multiregional brain-on-a-chip

Stephanie Dauth, Ben M Maoz, Sean P Sheehy, Matthew A Hemphill, Tara Murty, Mary Kate Macedonia, Angie M Greer, Bogdan Budnik, Kevin Kit Parker
March 3, 2014
Scientific American
The new century of the brain.

Yuste R, Church GM.
September 25, 2017
Nature Communications
The brain is required for normal muscle and nerve patterning during early Xenopus development

Celia Herrera-Rincon, Vaibhav P. Pai, Kristine M. Moran, Joan M. Lemire & Michael Levin
September 15, 2013
Dialogues in clinical neuroscience
BRAIN: innovative neurotechnologies for imaging and therapeutics.

Church GM
June 13, 2019
Nature Communications
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies

Tae-Eun Park, Nur Mustafaoglu, Anna Herland, Ryan Hasselkus, Robert Mannix, Edward A. FitzGerald, Rachelle Prantil-Baun, Alexander Watters, Olivier Henry, Maximilian Benz, Henry Sanchez, Heather J. McCrea, Liliana Christova Goumnerova, Hannah W. Song, Sean P. Palecek, Eric Shusta & Donald E. Ingber
March 18, 2015
Neuron
Traumatic Brain Injury and the Neuronal Microenvironment: A Potential Role for Neuropathological Mechanotransduction.

Hemphill MA,_Dauth S,_Yu CJ,_Dabiri BE,_Parker KK
March 30, 2015
Scientific Reports
Opposite rheological properties of neuronal microcompartments predict axonal vulnerability in brain injury.

Grevesse T,_Dabiri BE,_Parker KK, Gabriele S
October 14, 2015
Neuron
A National Network of Neurotechnology Centers for the BRAIN Initiative.

Alivisatos AP, Chun M, Church GM, Greenspan RJ, Roukes ML, Yuste R
June 16, 2011
Journal of Controlled Release
The efficacy of intracranial PLG-based vaccines is dependent on direct implantation into brain tissue

Ali OA, Doherty E, Bell WJ, Fradet T, Hudak J, Laliberte MT, Mooney DJ, Emerich DF
March 7, 2013
Science
The Brain Activity Map

Alivisatos, A.P., Chun, M., Church, G.M., Deisseroth, K., Donoghue, J.P., Greenspan, R.J., McEuen, P.L., Roukes, M.L., Sejnowski, T.J., Weiss, P.S., and Yuste, R.
July 16, 2015
Journal of Neuroscience Methods
Diagnostic tools for evaluating the impact of Focal Axonal Swellings arising in neurodegenerative diseases and/or traumatic brain injury.

Maia PD, Hemphill MA, Zehnder B, Zhang C, Parker KK, Kutz JN
March 1, 2016
PLoS One
Distinct contributions of astrocytes and pericytes to neuroinflammation identified in a 3-D human blood-brain barrier on a chip

Herland A, van der Meer AD, Fitzgerald E, Park T-E, Sleeboom JJF, Ingber DE
August 6, 2014
Science Translational Medicine
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes.

Stern JN, Yaari G, Vander Heiden JA, Church G, Donahue WF, Hintzen RQ, Huttner AJ, Laman JD, Nagra RM, Nylander A, Pitt D, Ramanan S, Siddiqui BA, Vigneault F, Kleinstein SH, Hafler DA, O'Connor KC
March 20, 2013
ACS Nano
Nanotools for Neuroscience and Brain Activity Mapping

Alivisatos AP, Andrews A, Boyden E, Chun M, Church G, Deisseroth K, Donoghue J, Fraser S, Lippincott-Schwartz J, Looger L, Masmanidis S, McEuen P, Nurmikko A, Park H, Peterka D, Reid C, Roukes M, Scherer A, Schnitzer M, Sejnowski T, Shepard K, Tsao D, Turrigiano G, Weiss P, Xu C, Yuste R, Zhuang X

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