Technology Area: Drug Development
172 Results for 'Drug Development'
- Technologies (11)
- Team (0)
- News (120)
- Events (0)
- Jobs (0)
- Publications (0)
- Multimedia (41)
Technologies 11
-
Microfluidic encapsulation for subcutaneous delivery of viscous drugs
Antibodies and other biopharmaceuticals have emerged as a powerful new class of drugs for treating diseases that range from rheumatoid arthritis to breast cancer to macular degeneration. However, these large, protein-based molecules cannot be taken orally (the stomach would digest them) and are frequently given at high concentrations. Most are administered intravenously, but that approach... -
A broad strategy to reduce the toxicity of protein drugs
Therapeutic variants of the natural hormone erythropoietin (EPO) which is produced in the kidney to boost the production of red blood cells are commonly used to treat anemias stemming from kidney disease, chemotherapy and other complications. However, many drugs that are based on therapeutic proteins, including EPO, often cause unwanted side effects because they not... -
DNA Nanostructures for Drug Delivery
Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program... -
Fluorescent In Situ Sequencing (FISSEQ)
Working copies of active genes — called messenger RNAs or mRNAs —translate the genetic information present in DNA into proteins within the cells’ multiple compartments. They are often positioned strategically within cells in ways that contribute critically to how cells and tissues grow, develop and function, and their mislocation can lead to disease development. To... -
Putting Biofilms to Work
A team at the Wyss Institute sees biofilms as a robust new platform for designer nanomaterials that could treat inflammatory bowel diseases, clean up polluted rivers, manufacture pharmaceutical products, fabricate new textiles, and more. A novel protein engineering system called BIND, which stands for Biofilm-Integrated Nanofiber Display, could be the essential ingredient in tomorrow’s probiotic... -
Implantable cancer vaccine
The Wyss Institute’s implantable, biodegradable cancer vaccine leverages immunotherapeutic methods and could one day help overcome melanoma, other cancers, infectious diseases, auto-immune diseases, as well as vaccinate against specific peptides, proteins, or antigens. The implant is a biodegradable polymer scaffold containing growth factors and components of each patient’s tumors. The technology was initially designed to...
News 120
Multimedia 41
-
Video/AnimationWyss Focus: Immuno-MaterialsWyss Core Faculty, Dave Mooney, explains our new Immuno-Materials Focus Area, which adds a new dimension to immunotherapy in that it harnesses materials to make treatments more efficient and effective. These material-based systems are capable of modulating immune cells and releasing them into the body where they can treat diseases. -
Video/AnimationDNA Bricks: Molecular AnimationThe nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying “recipe” of DNA base pairs. Animation created by Digizyme for the Wyss Institute. Credit: Wyss Institute at Harvard University -
Video/AnimationShrinking GelWhen the temperature rises to just below body temperature, this biocompatible gel shrinks dramatically within minutes, bringing tooth-precursor cells (green) closer together. Credit: Basma Hashmi -
Video/AnimationFluorescent in situ SequencingIn this video, George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School, explains how fluorescent in situ sequencing could lead to new diagnostics that spot the earliest signs of disease, and how it could help reveal how neurons in the brain connect and function. Credit:... -
Video/AnimationBioprinting: Building in Blood VesselsBuilding in blood vessels. Then they addressed a big challenge in tissue engineering: embedding 3D vascular networks. They developed a ‘fugitive’ ink that can easily be printed, then suctioned off to create open microchannels that can then be populated with blood-vessel-lining cells to allow blood to flow. Read more: wyss.harvard.edu/viewpressrelease/141 Credit: Wyss Institute at Harvard... -
Video/AnimationBioprinting: Building with Bio-InksBuilding with bio-inks. Using their custom-built printer, the fugitive ink for the vasculature, and other biological inks containing extracellular matrix and human cells, the researchers printed a 3D tissue construct. Credit: Wyss Institute at Harvard University