Technology Area: Microfluidics

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Microfluidic encapsulation for subcutaneous delivery of viscous drugs
Antibodies and other biopharmaceuticals have emerged as a powerful new class of drugs for treating diseases that range from rheumatoid arthritis to breast cancer to macular degeneration. However, these large, protein-based molecules cannot be taken orally (the stomach would digest them) and are frequently given at high concentrations. Most are administered intravenously, but that approach...
Project ABBIE
Over 15 million Americans are at risk of anaphylaxis, a severe allergic reaction triggered by exposure to certain foods, materials, medications and insect bites. Every three minutes a food reaction sends someone to the emergency room. In most individuals, anaphylactic shock can be prevented by administering the counteracting drug, epinephrine. Yet, despite effective treatments, death from...
Dynamic Daylight Control System
In the U.S. alone, commercial and residential buildings account for more than 40 percent of the total energy consumption – mostly for lighting. What’s more, the deep building layouts that are typical in the U.S. have led to a complete reliance on artificial lighting systems that are less desirable than natural daylight. Many of the...
Human Organs-on-Chips
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to...
3D Bioprinting of Living Tissues
Progress in drug testing and regenerative medicine could greatly benefit from laboratory-engineered human tissues built of a variety of cell types with precise 3D architecture. But production of greater than millimeter sized human tissues has been limited by a lack of methods for building tissues with embedded life-sustaining vascular networks. In this video, the Wyss...

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