Technology Area: Microfluidics

Technologies 5

• Microfluidic encapsulation for subcutaneous delivery of viscous drugs
  Antibodies and other biopharmaceuticals have emerged as a powerful new class of drugs for treating diseases that range from rheumatoid arthritis to breast cancer to macular degeneration. However, these large, protein-based molecules cannot be taken orally (the stomach would digest them) and are frequently given at high concentrations. Most are administered intravenously, but that approach...
• Project ABBIE
  Over 15 million Americans are at risk of anaphylaxis, a severe allergic reaction triggered by exposure to certain foods, materials, medications and insect bites. Every three minutes a food reaction sends someone to the emergency room. In most individuals, anaphylactic shock can be prevented by administering the counteracting drug, epinephrine. Yet, despite effective treatments, death from...
• Dynamic Daylight Control System
  In the U.S. alone, commercial and residential buildings account for more than 40 percent of the total energy consumption – mostly for lighting. What’s more, the deep building layouts that are typical in the U.S. have led to a complete reliance on artificial lighting systems that are less desirable than natural daylight. Many of the...
• Human Organs-on-Chips
  Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to...
• 3D Bioprinting of Living Tissues
  Progress in drug testing and regenerative medicine could greatly benefit from laboratory-engineered human tissues built of a variety of cell types with precise 3D architecture. But production of greater than millimeter sized human tissues has been limited by a lack of methods for building tissues with embedded life-sustaining vascular networks. In this video, the Wyss...

News 50

View all

• Press Release Lung cancer research gets a breath of fresh air
  October 10, 2017
• Community
  
  Symposium on Therapeutic Organ Engineering
  September 26, 2017
• Press Release Harvard’s Wyss Institute launches human Organ Chip project to model influenza virus infection and develop new therapies
  September 13, 2017

Multimedia 21

View all

• 

  Video/Animation
  8th Annual Wyss Institute Symposium: Therapeutic Organ Engineering
  Screened just before the symposium opening, this animation artistically connects concepts of therapeutic organ engineering presented during the event. Credit: Wyss Institute at Harvard University

• 

  Video/Animation
  Dynamic Daylight Redirection System
  This video shows Keojin Jin conducting a shoebox test that shows the light reflection effect to the top surface of the box as well as the reduction of direct light to the bottom surface of the box. Credit: Wyss Institute at Harvard University

• 

  Video/Animation
  Introduction to Organs-on-a-Chip
  What if we could test drugs without animal models? Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each...

• 

  Video/Animation
  Researchers mimic pulmonary edema in Lung-on-a-Chip
  The Wyss Institute’s human breathing lung-on-a-chip, made using human lung and blood vessel cells, acts much like a lung in a human body. A vacuum re-creates the way the lungs physically expand and contract during breathing. As reported in Science Translational Medicine on November 7, 2012, Wyss researchers have now mimicked a human disease –...

• 

  Video/Animation
  Bioprinting: Building Intricate Structures
  Building intricate structures. The team first designed a custom printer that can precisely co-print multiple materials in 3D to create intricate heterogeneous patterns. Credit: Wyss Institute at Harvard University

• 

  Video/Animation
  Bioprinting: Building with Bio-Inks
  Building with bio-inks. Using their custom-built printer, the fugitive ink for the vasculature, and other biological inks containing extracellular matrix and human cells, the researchers printed a 3D tissue construct. Credit: Wyss Institute at Harvard University