Donald E. Ingber
Donald E. Ingber, M.D., Ph.D.
Founding Director and Core Faculty,
Wyss Institute at Harvard University
Judah Folkman Professor of Vascular Biology,
Harvard Medical School and Vascular Biology Program, Boston Children's Hospital
Professor of Bioengineering,
Harvard John A. Paulson School of Engineering & Applied Sciences
Donald E. Ingber is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, and Professor of Bioengineering at the Harvard John A. Paulson School of Engineering and Applied Sciences. He received his B.A., M.A., M.Phil., M.D. and Ph.D. from Yale University.
Dr. Ingber has made major contributions to cell biology, mechanobiology, bioengineering, tissue engineering, nanobiotechnology, angiogenesis, cancer, medical device development, and translational medicine. He has authored more than 400 publications and 125 patents, founded 4 startups, presented more than 450 presentations world-wide, and received numerous honors in a broad range of disciplines, including membership in the National Academy of Medicine, National Academy of Inventors, and the American Institute for Medical and Biological Engineering.
Dr. Ingber’s work has catalyzed the convergence of far-reaching disciplines never before connected, ranging from biology, medicine, engineering, computer science and physics to art, architecture and design. These efforts helped to birth the field of Biologically Inspired Engineering, and at the Wyss Institute, he oversees a multifaceted mission to identify the mechanisms that living organisms use to self-assemble and self-regulate, and to apply these design principles to develop advanced materials and devices for healthcare and to improve sustainability. Examples of his most recent innovations include development of a dialysis-like sepsis therapeutic device that clears blood of pathogens and inflammatory toxins; a shear stress-activated nanotherapeutic that targets clot-busting drugs to sites of vascular occlusion; a non-stick surface coating for medical devices that replaces the need for anticoagulants; and Human “Organs-on-Chips” created with microchip manufacturing and lined by living human cells, which are being used to replace animal testing for drug development and personalized medicine. His Organs-on-Chips technology was named 2015 Design of the Year by the London Design Museum, and was acquired by the Museum of Modern Art (MoMA) in New York City for its permanent collection.
How do art, design, mechanics, and cell biology inspire bioengineering? In this interview segment, Don Ingber describes his path to the Wyss Institute and the different interests along the way that have inspired his work through the years.