Sherlock Biosciences

Sherlock Biosciences leverages technology from the Wyss Institute to create a highly sensitive, nucleic acid-based diagnostic platform that can rapidly deliver accurate and inexpensive results for a vast range of needs in virtually any setting

Wyss Technology: INSPECTR™ - A direct-to-consumer molecular diagnostic
News: Sherlock Biosciences Announces Close of Series A Round with Additional Investment Led by Northpond Ventures and Baidu Ventures
News: Sherlock Biosciences Licenses Wyss Technology to Create Affordable Molecular Diagnostics

ReadCoor

ReadCoor leverages the Wyss Institute’s method for simultaneously sequencing and mapping thousands of RNAs within cells and tissues to advance development of diagnostics and discover new drug targets

Wyss Technology: Fluorescent in situ Sequencing
Website: ReadCoor
Disruptive: Fluorescent in situ Sequencing
News: Wyss Institute launches ReadCoor to commercialize 3D in situ gene sequencing technology

Ultivue

Ultivue is developing innovative imaging solutions to unfold new areas of biology by leveraging the Institute’s DNA-PAINT technology. At the center of the technology is the transient binding of fluorophores to targets mediated by DNA-DNA interaction

Wyss Technology: Inexpensive Super-Resolution Microscopy
Website: Ultivue
News: Ultivue Launches UltiMapper™ Portfolio of Reagents for Tissue Marker Detection and Analysis at High Level of Multiplexing and Throughput
News: Ultivue Inc. Announces Completion of its Series B Financing
News: Harvard’s Wyss Institute launches Ultivue to facilitate super-resolution microscopy

Emulate

Emulate leverages the Wyss Institute’s organs-on-chips technology to emulate human biology towards understanding how diseases, medicines, chemicals, and foods affect human health

Wyss Technology: Human Organs-on-Chips
Website: Emulate
News: Emulate, Inc. Awarded Grant to Use Intestine-Chip to Study Human GI Infections Aboard the International Space Station
News: Founders Fund Leads $36 Million Financing Round in Emulate, Inc.
News: Emulate, Inc. and AstraZeneca form strategic agreement to work side-by-side on Organs-on-Chips technology to improve prediction of human safety and efficacy of drug candidates
News: Emulate, Inc. Awarded Grant to Fund Use of Human Emulation System aboard the International Space Station
News: ‘Organs-on-Chips’ Technology: FDA Testing Groundbreaking Science
News: Organ-On-A-Chip Startup, Emulate, Grabs $45M to Shake Up Drug Discovery
News: Wyss Institute’s technology translation engine launches ‘Organs-on-Chips’ company

NuProbe

NuProbe utilizes DNA toehold probe systems to develop non-invasive cancer and infectious disease diagnostics

Website: NuProbe
News: Harvard’s Wyss Institute launches NuProbe to facilitate global precision medicine

FitBiomics

FitBiomics utilizes next-generation sequencing to identify and isolate novel probiotic bacteria for applications in sports performance and recovery

Website: FitBiomics
Wyss Technology: Sports Genomics
Disruptive: Sports Genomics
News: Discovery of performance-enhancing bacteria in the human microbiome
News: National Geographic’s Explorer episode “Race Car Science” investigates DNA testing and new probiotics

Root Robotics

Root Robotics, acquired by iRobot, is commercializing Root, an educational and interactive robot to teach coding to many age groups and experience levels

Wyss Technology: Root
Website: Root Robotics
News: The Little Robot That Could
News: iRobot Introduces the Root Coding Robot Through Acquisition of Root Robotics
News: 10 amazing toys that can teach your kids how to code
News: This robot can help your kids learn to code
News: CES 2018: The Root aims to teach kindergartners how to code
News: TechRadar's 2018 CES Awards – the best tech at the show
News: Harvard’s Wyss Institute launches Root Robotics, an educational startup to get anyone coding

FreeFlow Medical Devices

FreeFlow Medical Devices uses an anti-adhesive coating technology to eliminate the formation of biofilms and blood clots on the surfaces of medical devices

Wyss Technology: Tethered Liquid Perfluorocarbon (TLP), a non-stick coating for medical devices
Website: FreeFlow Medical Devices
News: Bioinspired coating for medical devices repels blood and bacteria
Video: Bioinspired Blood Repellent Coating

Adaptive Surface Technologies

Adaptive Surface Technologies (formerly SLIPS Technologies, Inc.) leverages the Wyss Institute’s Slippery Liquid-Infused Porous Surfaces (SLIPS) technology to create a family of materials and coatings that repel virtually all fluids and biological fouling agents in industrial, medical, and consumer applications

Wyss Technology: SLIPS (Slippery Liquid-Infused Porous Surfaces)
Website: Adaptive Surface Technologies
News: Johnson & Johnson Innovation Announces New Collaborations Advancing Ground-Breaking Biomedical Innovation Around the Globe
News: SLIPS Technologies Announces $8.6 Million in New Funding Round
News: Materials and engineering: Rebuilding the world
News: Wyss Institute launches ‘SLIPS’ company

MediCollector

MediCollector uses the Institute’s data acquisition algorithms to enable continuous collection of data to better characterize physiological changes and treatment in patients

Wyss Technology: Preventing Infant Apnea
Website: MediCollector
News: Wyss software licensed for hospital bedside data collection

BIOMOD

Birthed at the Wyss Institute, BIOMOD is now an independent, international biomolecular design competition based in San Fransisco

Website: BIOMOD

Biomaterial-based cancer immunotherapy

Novartis is developing a therapeutic, biomaterial-based, cancer vaccine that promotes anti-cancer immunity for specific targets

Wyss Technology: Implantable cancer vaccine
News: Harvard bioengineers’ biomaterial-based cancer immunotherapies to be developed by Novartis
News: Personal cancer vaccine gets their own boost
News: Injectable 3D vaccines could fight cancer and infectious diseases
News: Cross-disciplinary team from Harvard University and Dana-Farber Cancer Institute brings novel therapeutic cancer vaccine to human clinical trials
News: First cancer vaccine to eliminate tumors in mice

Soft exosuit for stroke

The Institute’s soft exosuit technology has been licensed by ReWalk Robotics, Ltd. towards further development of concepts and designs of lightweight exoskeleton system technologies for medical applications such as stroke and multiple sclerosis. Licensing opportunities are available for other soft exosuit applications.

Wyss Technology: Soft exosuit
News: FDA Issues Clearance for the ReStore™ Exo-Suit, the First Soft Robotic System for Stroke Therapy
News: ReWalk Robotics Receives CE Mark for ReStore™ Exo-Suit Stroke Rehabilitation Device
News: Post-stroke patients reach terra firma with Wyss Institute’s exosuit technology
News: Wyss Institute collaborates with ReWalk Robotics to develop wearable exosuit for patients with limited mobility

CRISPR genome editing

Editas is leveraging Institute CRISPR technology towards genome editing for the treatment of patients with genetically defined diseases.

Website: Editas
News: Broad Institute, Harvard and MIT license CRISPR-Cas9 technology to Editas Medicine for therapeutic applications

Infant health-promoting vibrating mattress

Prapela is leveraging the Institute’s infant health-promoting technology to develop an inexpensive Stochastic Vibro-tactile Simulation hospital bassinet pad to help normalize infants’ cardiorespiratory functions. This technology is based on the principle of “Stochastic Resonance”, which holds that white noise can boost weak signals in neuronally and other biological processes.

Wyss Technology: Preventing Infant Apnea
Website: Prapela
News: Ohio Advances New Solutions to Prevent and Treat Drug Abuse and Addiction
News: Wyss Institute’s infant health-promoting technology licensed to Prapela
News: Effectiveness of infant apnea prevention technology
News: Prapela Awarded NIH/NIDA Grant Focused On Neonatal Abstinence Syndrome (NAS)

CRISPR-mediated organ engineering

eGenesis is facilitating the development of safe and effective cells, tissues, and organs for future medical transplantation into human patients.

Website: eGenesis
News: Pig organs for human patients: A challenge fit for CRISPR
News: Removing 62 barriers to pig-to-human organ transplant in one fell swoop

Minimally invasive surgical device

A specialized catheter device that can repair holes in the heart or tissue defects in other organs has been licensed by HoliStick Medical. Designed to work with sticky and flexible materials such as patches, the device incorporates mechanisms to delicately close a hole without requiring the use of sutures or rigid devices.

News: Startup promises minimally invasive heart repair
News: Fixing holes in the heart without invasive surgery

Protein therapeutics with enhanced properties

GRO Biosciences is leveraging breakthrough technologies from computational protein design and synthetic biology to develop improved protein therapeutics for diabetes, growth disorders and autoimmunity.

Website: GRO Biosciences
News: George Church Lab Spinout, GRO Biosciences, Secures $2.1 Million in Seed Funding

Soft robotic actuators

Soft Robotics designs and builds automation solutions and soft robotic gripping systems that can grasp and manipulate items with the same dexterity of the human hand.

Website: Soft Robotics
News: Cambridge-based Soft Robotics to hire, move HQ following $20M raise
News: Actuators inspired by muscle
News: Soft Robotics Inc. Holds First Close of Series A Funding
News: Soft Touch: Squishy Robots Could Lead to Cheaper, Safer Medical Devices

3D printed electronic parts

Voxel8 integrates capabilities in materials science, software, and hardware to produce an additive manufacturing platform that co-prints hard, soft, and electronic materials for functional industrial parts. The company is leveraging some of the Institute’s 3D printed electronic parts.

Website: Voxel8

Artificial robot swarms for education and research

A collective of 1024 ‘Kilobots’ (a kilo of robots) that can be programmed to exhibit complex swarming behaviors has been licensed by K-Team Corporation, which is manufacturing and marketing the novel robot "swarm" system for use in education and research.

Website: K-Team Corporation
Wyss Technology: Programmable robot swarms
News: Wyss Institute Signs Licensing Agreement with K-Team Corporation

Ultraspecific nucleic acid hybridization probes for detection and counting

A new class of ultraspecific nucleic acid hybridization probes that can improve the detection of naturally occurring genetic sequences has been licensed to NanoString Technologies. Licensing opportunities are available for other applications.

Website: NanoString Technologies
News: NanoString Technologies Introduces New Universal Junction Probe Design for Detecting Gene Fusions