Application Area: Fundamental Research

Technologies 3

• Fluorescent In Situ Sequencing (FISSEQ)
  Working copies of active genes — called messenger RNAs or mRNAs —translate the genetic information present in DNA into proteins within the cells’ multiple compartments. They are often positioned strategically within cells in ways that contribute critically to how cells and tissues grow, develop and function, and their mislocation can lead to disease development. To...
• Multiplexed Molecular Force Spectroscopy
  Programmable DNA nanoswitches, invented at the Wyss Institute, can now be used in combination with a benchtop Centrifuge Force Microscope (CFM) as a highly reliable tool to observe thousands of individual molecules and their responses to mechanical forces in parallel. By analyzing the responses of single molecules under conditions where they experience such forces, it is possible...
• Inexpensive Super-Resolution Microscopy
  Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...

News 19

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• Press Release Slippery liquid surfaces confuse mussels to stop them from sticking to underwater structures
  August 17, 2017
• Image Harvard researchers develop tough, self-healing rubber
  August 14, 2017
• Press Release Taking cells out to the movies with new CRISPR technology
  July 12, 2017

Multimedia 4

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  Video/Animation
  Disruptive: Mechanotherapeutics – From Drugs to Wearables
  Mechanobiology reveals insights into how the body’s physical forces and mechanics impact development, physiological health, and prevention and treatment of disease. The emerging field of Mechanotherapeutics leverages these insights towards the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways...

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  Audio/Podcast
  Disruptive: Sports Genomics
  With 100 trillion cells in the human body, bacteria outnumber our own human cells 2 to 1. These bacteria make up one’s microbiome, and particularly bacteria in our guts affect all our key organ functions. They play a role in our health, development and wellness, including endurance, recovery and mental aptitude. In this episode of...

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  Video/Animation
  Bioprinting: The Kidney’s Proximal Tubules
  In this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Octobot: A Soft, Autonomous Robot
  The Octobot is the first entirely soft, autonomous robot. It is made by a combination of embedded 3D printing, modeling, and soft lithography. Inspired by real octopuses, the Octobot has no rigid components. It is powered by a chemical reaction and controlled with a microfluidic logic that directs the flow of fuel. The logic circuit...