Discipline: Genome Engineering
68 Results for 'Genome Engineering'
- Technologies (3)
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- News (59)
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Technologies 3
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AAV-Engineering For Advanced Gene Therapy
Gene therapy with AAV (adeno-associated virus) as a delivery vehicle is a leading therapeutic modality for genetic disorders that is approved in Europe for the metabolic disease Familial Lipoprotein Lipase Deficiency. It is currently being tested in clinical trials in the U.S. to treat other rare conditions like the retinal Leber Congenital Amaurosis and the... -
High Density Information Storage in DNA
A new method developed at the Wyss Institute allows for synthesis of oligonucleotides by the thousands on a single DNA microchip — a collection of thousands of different DNA segments attached to a glass slide or other solid surface. Until now, generating long strands of DNA has been challenging and labor-intensive. Yet Wyss researchers have... -
Multiplex Automated Genomic Engineering (MAGE)
Developed at the Wyss Institute, MAGE harnesses the natural principles of evolution to do all the heavy lifting of genome design and automates these steps to dramatically shorten the time scale required to produce microbes with specialized functionalities for manufacturing, sensing and therapeutic applications. Genome engineering has a wide range of applications, from developing new...
News 59
Multimedia 6
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Audio/PodcastDisruptive: Synthetic BiologyWhat sorts of breakthroughs are possible by modifying an organism’s genome – something researchers are now able to do ever more cheaply and efficiently? Researchers around the world are already able to program microbes to treat waste water, generate electricity, manufacture jet fuel, create hemoglobin, and fabricate new drugs. What sounds like science fiction to... -
Video/AnimationCRISPR-Cas9: Safeguarding Gene DrivesIn this animation, learn how effective safeguarding mechanisms developed at the Wyss Institute and Harvard Medical School can be applied to ensure gene drive research is done responsibly in the laboratory. These safeguards enable responsible scientific investigation into how gene drives could one day be leveraged for the greater good of human health, agriculture, and... -
Video/AnimationCRISPR-Cas9: Gene Target TroubleshootingIn this animation, learn how a “library on library” approach was used to create a software algorithm that can predict the best way to target any specific gene. Using the most effective RNA sequence, which can be selected using the novel software’s ranking and scoring algorithm, the gene editing mechanism known as CRISPR-Cas9 can be... -
Video/AnimationCas9: As a Transcriptional ActivatorIn this technical animation, Wyss Institute researchers instruct how they engineered a Cas9 protein to create a powerful and robust tool for activating gene expression. The novel method enables Cas9 to switch a gene from off to on and has the potential to precisely induce on-command expression of any of the countless genes in the... -
Video/AnimationGene Editing Mechanism of CRISPR-Cas9In this animation, learn how CRISPR-Cas9 gene editing technology can be used to precisely disrupt and modify specific genes. Credit: Wyss Institute at Harvard University. -
Video/AnimationCRISPR-Cas9: Gene DrivesThis animation explains how an emerging technology called “gene drives” may be used to potentially spread particular genomic alterations through targeted wild populations over many generations. It uses mosquitoes as an example of a target species – and illustrates how the versatile genome editing tool called CRISPR makes it possible. For information, please visit our...