Discipline: Nanobiotechnology

Technologies 13

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• DNA Nanoswitches: “Lab-on-a-Molecule” Drug Discovery
  The Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions.
• DoriVac: Boosting Antigen-specific Immune Responses with DNA Origami-Based Vaccines
  Personalized cancer and infectious disease vaccine platform harnessing DNA nanotechnology to control the co-delivery and co-presentation of tumor antigen and adjuvant ligands to immune cells with nanoscale precision. This approach has potential to trigger enhanced immune responses against tumors and infectious pathogens.
• Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics
  This nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers.
• DNA Nanotechnology Tools: From Design to Applications
  A suite of diverse, multifunctional DNA nanotechnological tools with unique capabilities and potential for a broad range of clinical and biomedical research areas. Our DNA nanotechnology devices were engineered to overcome specific bottlenecks in the development of new therapies and diagnostics, and to help further our understanding of molecular structures.
• abbieSense: Anaphylaxis Diagnostic
  The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately...
• Biomaterial Scaffolds for T Cell Expansion
  Immunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying...

Collaborations 1

• Kraft Heinz Partnership
  The Kraft Heinz company approached the Wyss Institute for help to achieve its ambitious goal to make its food products healthier, resulting in a novel technology that is ripe for commercialization.

News 86

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• Press Release
  
  Wyss Institute’s Lab-on-a-Molecule Drug Discovery Project Receives Funding from Northpond Labs
  April 4, 2023
• Press Release
  
  DNA nanostructures grow up to become micron-scale megastructures
  December 21, 2022
• Press Release
  
  Turning the spotlight on cells in tissues so RNA can tell their story
  October 10, 2022

Multimedia 26

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  Video/Animation
  Seed-dependent crisscross DNA-origami slats
  This animation explains how the newly invented crisscross origami method can be used to build functionalized micron-scale DNA megastructures composed of many unique DNA origami “slats,” each with their own complexity and interactive properties. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Light-Seq: Light-Directed In Situ Barcoding of Biomolecules
  This animation explains how the Light-Seq technology works to barcode and deep-sequence selected cell populations in tissue samples, and how the team applied it to the analysis of distinct and rare cells in the mouse retina. Credit: Wyss Institute at Harvard University.

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  Audio/Podcast
  Illuminating Biological Context with Josie Kishi – Translation by Fifty Years
  Technologies like next-generation sequencing allow us to understand which RNA transcripts and proteins are expressed in biological tissues. However, it’s often equally important to understand how cells or molecules are positioned relative to one another! Whether it be a cell changing its shape, an organelle ramping up a metabolic process, or a DNA molecule traveling...

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  Video/Animation
  Lighting up proteins with Immuno-SABER
  This animation explains how Immuno-SABER uses the Primer Exchange Reaction (PER) to enable the simultaneous visualization of multiple proteins in tissues in different applications. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  SABER-FISH: Enabling the sensitive and multiplexed detection of nucleic acids within thick tissues
  This animation shows how SABER-FISH uses a suite of DNA nanotechnological methods that together enable the sensitive and multiplexed detection of DNA and RNA targets within cells and thick tissues. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Light-driven fine chemical production in yeast biohybrids
  Wyss Institute Core Faculty member Neel Joshi explains the concept of yeast biohybrids and how they can be used to harvest energy from light to drive the production of fine chemicals. Credit: Wyss Institute at Harvard University