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Jobs 5

• Postdoctoral Fellowship – Hierarchical self-assembly of DNA origami into addressable microstructures
  Academic Position

  About the Wyss:

  The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances. For more information, discover our technologies, catch up on our recent news, or watch our latest videos.

  Role Description:

  The William Shih Laboratory, which explores design principles for self-assembling molecular machines, invites applications for a postdoctoral fellow position in the Wyss Molecular Robotics Initiative.  We seek outstanding postdoctoral applicants with expertise in biomolecular engineering or science to develop hierarchical self-assembly of hundreds to thousands of distinct DNA origami into addressable microstructures, exploiting the principles of crisscross assembly innovated in our lab. Potential applications of interest include artificial extracellular matrices for regenerative medicine, breadboards for localized molecular computing, and nanophotonic devices.

  What You’ll Need:

  • Ph.D. with an excellent track record of research involving design and characterization of biomolecules.
  • The candidate should be open-minded, creative, energetic, and critical thinking.

  Benefits and Perks:

  • Medical/Dental/Vision: We offer a variety of excellent medical, dental, & vision plans. All coverage begins as of your start date.
  • Time Off: 20 days of vacation per year
  • Tuition Assistance Program: Competitive tuition assistance program, classes at the Harvard Extension School and discounted options through participating Harvard grad schools.
  • Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
  • Wellness Options: Harvard offers programs and classes at little or no cost, including stress management, nutrition, meditation, and complimentary health services.

  Where You Can Apply:

  Applications, assembled as single PDF files, should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation). Applications should be sent to faculty_postdocs@wyss.harvard.edu using the subject line “DNA origami”.

  Working Conditions
  

  Harvard requires COVID vaccination for all Harvard community members. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/.

  Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

  Learn more

• Postdoctoral Fellow – DNA-Nanostructured Therapeutic Delivery Vehicles
  Academic Position

  About the Wyss:

  The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances. For more information, discover our technologies, catch up on our recent news, or watch our latest videos.

  Role Description:

  The Shih Laboratory explores design principles for self-assembling molecular machines. We seek outstanding postdoctoral applicants with expertise in biomolecular engineering or science to work with Institute faculty, postdoctoral fellows, and research staff to develop an approach that will develop DNA-nanostructured vehicles for therapeutic delivery of cargo to cytoplasmic and organellar destinations.

  What You’ll Need:

  • Applicants are expected to hold a Ph.D.
  • Excellent track record of research involving design and characterization of biomolecules.

  Preferred:

  • Proficiency with cell culture is a plus.
  • The candidate should be open-minded, creative, energetic, and critical thinking.

  Benefits and Perks:

  • Medical/Dental/Vision: We offer a variety of excellent medical, dental, & vision plans. All coverage begins as of your start date.
  • Time Off: 20 days of vacation per year
  • Tuition Assistance Program: Competitive tuition assistance program, classes at the Harvard Extension School and discounted options through participating Harvard grad schools.
  • Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
  • Wellness Options: Harvard offers programs and classes at little or no cost, including stress management, nutrition, meditation, and complimentary health services.

  Where You Can Apply:

  Please submit a full application which should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation). Applications can be submitted through ARIeS, Harvard’s online portal. For any additional questions, please reach out to academic.affairs@wyss.harvard.edu.

  Working Conditions:

  Harvard requires COVID vaccination for all Harvard community members. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/.

  Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

  Learn more

• Postdoctoral Fellow – 3D Bioprinting of Functional Kidney Tissues
  Academic Position

  About the Wyss:

  The mission of the Wyss Institute for Biologically Inspired Engineering at Harvard University is to transform human healthcare and the environment by emulating the way nature builds. Developed as an alliance between Harvard and other premier academic and clinical partner institutions, Institute faculty and staff collaborate in high-risk, fundamental research and science-driven technology development. A major focus of the Institute is to translate the technologies developed by its faculty and staff into commercial products and therapies through collaborations with clinical investigators and establishment of corporate alliances. For more information, discover our technologies, catch up on our recent news, or watch our latest videos.

  Role Description:

  

  The Wyss Institute for Biologically Inspired Engineering at Harvard University seeks a talented Postdoctoral Fellow who is an engineer interested in biology research, or a biologist looking for engineering applications to join our Kidney team. Led by Jennifer Lewis and with technical guidance from the multidisciplinary bioprinting research team, you will work to complete independent and team research projects involving 3D bioprinting using stem-cell derived human kidney organoids. The work will focus on building from organ-on-chip platforms to more functional organ-level tissues. Projects in our lab typically span multiple disciplines, so we welcome applicants from many backgrounds. Successful applicants typically have some level of hands-on experience designing and fabricating devices or have strong background in relevant biological assays.

  In This Role You Will:

  • Complete independent and team research projects involving 3D bioprinting using stem-cell derived human kidney organoids
  • Focus on building from organ-on-chip platforms to more functional organ-level tissues
  • Participate in writing research proposals, reports, patent applications, presentations, and publications, providing critical data, figures or information for grant and patent submissions

  What You’ll Need:

  • Ph.D. in biology, microbiology, biomedical engineering, chemical engineering, materials science, electrical engineering, mechanical engineering or a related discipline.
  • Must demonstrate broad theoretical and practical knowledge within the fields of mechanical engineering, tissue engineering, or cell biology.
  • Strong scientific track record demonstrating well-organized design and execution of studies.
  • Ability to work independently as well as in a collaborative team environment.
  • Strong work ethic, communication skills and team-player oriented personality.

  Preferred:

  We are looking for a candidate with strong expertise in a few of the following areas, and a willingness to learn new skills outside of your current discipline to accomplish project goals. It would be terrific if you have experience in all of them, but this is not necessary, we can teach you what you don’t know.

  • Strong understanding of cell biology, physiology, and/or tissue engineering.
  • Cell culture experience.
  • Experience with in vitro analytical techniques to assess the cell viability of tissue constructs.
  • Experience with microfluidics.
  • Experience working with induced pluripotent stem cells.
  • 3D printing experience.
  • Experience with flow cytometry, ELISAs, PCR, or confocal microscopy.
  • Experience with vascularizing tissue.
  • Experience with animal implantation experiments.

  Benefits and Perks:

  • Medical/Dental/Vision: We offer a variety of excellent medical, dental, & vision plans. All coverage begins as of your start date.
  • Time Off: 20 days of vacation per year plus Harvard Holidays
  • Tuition Assistance Program: Competitive tuition assistance program, classes at the Harvard Extension School and discounted options through participating Harvard grad schools.
  • Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
  • Wellness Options: Harvard offers programs and classes at little or no cost, including stress management, nutrition, meditation, and complimentary health services.

  Where You Can Apply:

  Please assemble your application as a single PDF file, this should contain a complete resume, cover letter describing research interests and goals, full list of publications, copies of up to three relevant scientific papers, as well as the names and contact information of three references (expected to provide letters of recommendation). Applications should be sent to Jennifer Lewis at jalewis@seas.harvard.edu and Scott Slimmer at slimmer@g.harvard.edu using the subject line “Lewis Lab Postdoctoral Fellow Application.”

  Working Conditions
  

  Harvard requires COVID vaccination for all Harvard community members. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/.

  Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

  Learn more

• Visiting Graduate Researcher (Master’s Degree Intern) – Brain Shuttle Discovery in the Brain Targeting Program
  Academic Position

  Starting: Flexible

  Duration: 6 months to 1 year

  About the Wyss:

  The Wyss Institute’s mission is to transform healthcare and the environment by emulating the way nature builds. We harness the imagination of academia and the focus of industry to translate ground-breaking technologies into commercial products that solve big problems. We support research that universities, companies, and venture capital firms don’t fund because they view it as too risky. We prefer to use the word “challenging,” and we love challenges. For more information, discover our technologies, catch up on our recent news, or watch our latest videos.

  Role Description:

  The Wyss Institute for Biologically Inspired Engineering at Harvard University invites applications for Visiting Graduate Researcher position on the Brain Shuttle Discovery team of the Brain Targeting Program (BTP). This position will focus on brain shuttle compound discovery and brain-targeted therapeutics discovery.

  The Wyss Institute’s BTP, co-led by James Gorman, M.D., Ph.D. and Donald Ingber, M.D., Ph.D., is pursuing multiple projects directed to improved methods of transport across the blood-brain barrier (BBB) into the brain, with the aim of improving treatments for diverse diseases of the central nervous system. The brain shuttle discovery team focuses on two main areas. The first is discovery and validation of novel antibody (Ab) shuttle compounds that can greatly enhance the transport of therapeutics across the BBB to the brain. The second is optimization of our brain shuttles for specific payloads and diseases. By combining the BTP’s brain shuttles with therapeutics, we aim to develop novel, efficient brain-targeted drugs that significantly improve therapeutic efficacy for brain diseases. The Wyss team collaborates with academic collaborators and industry sponsors and partners to advance the development of novel brain targeting therapeutics.

  Applicants should have knowledge of the brain, understand basic cell biology, and have laboratory training. The applicant is expected to perform tissue culture, rodent tissue lysate preparation, ELISAs, western blotting and others with training and guidance. The candidate will have one primary mentor, receive rigorous training, exposure to multiple disciplines, and gain in-depth knowledge about the BBB and brain shuttle discovery, preparing them to pursue academic or biopharmaceutical careers.

  In This Role You Will:

  • Learn the cutting-edge technologies and research in the field of brain shuttles and brain-targeted therapeutics from our state-of the-art literature collections.
  • Participate in the entire process of in vivo animal pharmacokinetic/pharmacodynamic (PK/PD) studies to evaluate the uptake and biodistribution of brain shuttles.
  • Design and execute in vitro experiments to validate the affinity of brain shuttle Abs and to perform the initial screening of Ab panels.
  • Summarize, present, and share key findings with an interdisciplinary scientific team in a compelling, organized manner.
  • Collaborate with other researchers to address and solve new challenges and unanticipated problems as they arise.
  • Work as independently as possible, in a detail-oriented, self-driven manner.

  What you’ll need

  • Applicants must hold a MSc degree in the field of Biology, Neuroscience, Bioengineering, Pharmaceutic science, or a closely related discipline. PhD holders are not eligible for this position.
  • Scientific, Practical, and Interpersonal Skills:
    • Soft Skills: communication, adaptability, independent thinking, efficiency, self-drive
    • Computer Skills: Microsoft Office (Word, PowerPoint, Excel), Prism, etc.
    • Scientific Skills: gather/analyze data and generate presentable results, knowledge of basic BBB biology and neurodegenerative disorders/brain cancers/etc., knowledge of PKPD analyses, etc.

  Preferred:

  • Experience with basic immunoassays: ELISA, Western Blot, IHC, etc.
  • Experience with mouse studies and mouse tissue handling.
  • Experience with tissue histology: tissue fixation, cryosection, etc.
  • Experience with cell culturing and cell analysis: flow cytometry, etc.

  Please Note:  This position is unpaid. The applicant must be enrolled in a degree program for the duration of their visit and must receive academic credit for this experience.  They must also be able to fund their own travel and living expenses or have secured an external source of fellowship support.

  Where You Can Apply:

  Applications, assembled as a single PDF file, should contain a complete resume and a cover letter describing research interests, goals, and why you would be a good fit for this program. Applications should be sent to faculty_postdocs@wyss.harvard.edu using the subject line “Compound Discovery Visiting Graduate Researcher I”.

  Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law. Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.

  Learn more

• Visiting Student & Internship Opportunities
  Academic Position

  While the Wyss Institute does not currently have a formal internship program, we encourage you to reach out directly to the faculty members and/or Advanced Technology Team members whose work aligns with your research interests to inquire about the possibility of working with their group as an intern.

  When emailing faculty members and/or Advanced Technology Team members, please make sure to include your CV and your research background.

  You can find contact information for each of our team leads by visiting the Advanced Technology Team page.

  Learn more