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Technologies 11

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• DNA Nanostructures for Drug Delivery
  Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program...
• Lactation Biologics: Increasing Milk Production for Healthier Babies
  Lactation Biologics is developing a long-lasting, self-injectable treatment to help nursing mothers feed their babies naturally, helping them get the best nutrition possible in the face of climate disasters and supply chain disruptions.
• Sparkle: Instant Biosensors for Real-Time Imaging
  Sparkle is revolutionizing the binder assay industry by harnessing novel chemistry to create instant fluorescent biosensors for a wide variety of uses.
• Molecular Nucleic Acid Detection Technology to Empower Patients with Self-Testing Capabilities
  This technology provides an innovative molecular diagnostic assay for high-speed, sensitive, and specific detection of nucleic acids from SARS-CoV-2 or other pathogens, performed in a newly devised reusable base unit with pathogen-specific, one-time-use consumables – first prototyped at the Wyss Institute, then transformed into an inexpensive, reliable and manufacturable detection system by 3EO Health.
• SPEAR: Ultrasensitive Protein Detection in Small Samples
  Spear Bio uses a DNA nanotechnology-driven approach developed at the Wyss Institute that allows the sensitive detection of protein biomarkers in small samples using standard instruments to create new research and diagnostic assays. An ultra-sensitive assay detecting neutralizing antibodies against SARS-CoV-2 will be the first to be commercialized.
• Rapid Metabolite-Sensing System for Blood Lactate
  In emergency medicine, blood lactate levels are a reliable real-time indicator of the severity and mortality risk of conditions that occur as a result of poor blood circulation and oxygen supply to organs and tissues (hypoperfusion), such as in patients with sepsis, cardiac arrest, stroke, major trauma, cystic fibrosis and other conditions. Lactate levels also...

Collaborations 2

• Brigham-Wyss DxA
  The Wyss DxA's clinical partners from Brigham and Women’s Hospital identify the most pressing unmet diagnostic needs, provide access to high-quality patient samples for our Biomarker Discovery Laboratory (BDL) and Brigham-Wyss DxA collaborators, and provide invaluable feedback and guidance on the engineering and validation of cost-effective, sensitive, and specific diagnostic tests.
• Biomarker Discovery Laboratory (BDL)
  Bridging the diagnostic gap from biomarker discovery to market-ready test kits and instruments through cutting-edge technology development and clinical collaboration.

News 70

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• Press Release
  
  Wyss Institute’s AminoX project receives funding from Northpond Labs to accelerate innovation in protein-based therapeutics
  April 8, 2024
• Press Release
  
  “Suspended animation” drug could aid organ transplantation and survival from traumatic injury
  February 6, 2024
• Awards
  
  Highly Cited Researchers 2023 honors 13 Wyss faculty members
  November 15, 2023

Multimedia 23

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  Video/Animation
  Enhancing Lactation to Improve Infant and Maternal Health
  Lactation Biologics is developing a long-lasting, self-injectable treatment to help nursing mothers feed their babies naturally, helping them get the best nutrition possible in the face of climate disasters and supply chain disruptions. Credit: Wyss Institute at Harvard University

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  Video/Animation
  DNA Nanoswitch Calipers
  The world’s tiniest ruler for biomolecules has been created by researchers at the Wyss Institute at Harvard University, Harvard Medical School, and Boston Children’s Hospital. DNA Nanoswitch Calipers can measure very small peptides to better understand their structure and function, and enable them to be quickly identified in mixed samples. These insights could lead to...

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  Video/Animation
  Circe: Using Microbes to Make Biodegradable Products
  Current manufacturing methods release harmful greenhouse gases and pollution, and many of the products produced do not biodegrade, damaging our ecosystems even further. What if we could turn greenhouse gases into biodegradable products? Researchers at the Wyss Institute are using synthetic biology to make this a reality. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Light-driven fine chemical production in yeast biohybrids
  Wyss Institute Core Faculty member Neel Joshi explains the concept of yeast biohybrids and how they can be used to harvest energy from light to drive the production of fine chemicals. Credit: Wyss Institute at Harvard University

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  Video/Animation
  abbieSense
  abbieSense is a Wyss technology that can detect histamine levels in human body fluids and determine the severity of an allergic reaction, which could help save the lives of patients with severe allergies. Credit: Wyss Institute at Harvard University

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  Video/Animation
  This is Your Brain on Chips
  How do you study something as complex as the human brain? Take it apart. Wyss researchers have created Organ Chips that mimic the blood-brain barrier and the brain and, by linking them together, discovered how our blood vessels and our neurons influence each other. Credit: Wyss Institute at Harvard University