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Technologies 3

• Pathogen Capture Technology for Infectious Disease Therapeutics and Diagnostics
  Microbial contamination is the cause of life-threatening cases of sepsis, meningitis and multiple other infectious diseases that are a major cause of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of microbial contaminants must be confirmed, and when they are found, they need to...
• Human Organs-on-Chips
  Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to...
• Project ABBIE
  Over 15 million Americans are at risk of anaphylaxis, a severe allergic reaction triggered by exposure to certain foods, materials, medications and insect bites. Every three minutes a food reaction sends someone to the emergency room. In most individuals, anaphylactic shock can be prevented by administering the counteracting drug, epinephrine. Yet, despite effective treatments, death from...

News 5

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• Video/​Animation To improve health monitoring, simply trip the ‘nanoswitch’
  September 11, 2017
• Translation News FDA to evaluate Organs-on-Chips
  April 11, 2017
• Community Zika test spreads synthetic biology innovation around the world
  December 19, 2016

Multimedia 2

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  Video/Animation
  Project ABBIE
  Project ABBIE is inspired by the story of Abbie Benford, who succumbed to complications related to anaphylaxis just eight days before her 16th birthday. The Wyss Institute, in collaboration with Boston Children’s Hospital, is developing a wearable, non-invasive device that could sense anaphylaxis and automatically inject epinephrine in individuals who are unable to do so...

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  Video/Animation
  Lung-on-a-Chip
  Combining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. This extended version of the video includes our findings when we mimicked pulmonary edema on the chip. Credit: Wyss Institute at Harvard University