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Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics
This nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers. -
Extracellular Vesicles for Biomarker Detection
A non-invasive method to identify biomarkers of disease across cell types and develop diagnostics and monitoring systems. -
directEsense: Revolutionizing Animal Diagnostic Testing at the Point-of-Care
Electrochemical biosensors using a novel surface chemistry offer new opportunities for portable diagnostics with the potential to detect many disease biomarkers in animals and beyond. -
SPEAR: Ultrasensitive Protein Detection in Small Samples
Spear Bio uses a DNA nanotechnology-driven approach developed at the Wyss Institute that allows the sensitive detection of protein biomarkers in small samples using standard instruments to create new research and diagnostic assays. An ultra-sensitive assay detecting neutralizing antibodies against SARS-CoV-2 will be the first to be commercialized. -
Rapid Metabolite-Sensing System for Blood Lactate
In emergency medicine, blood lactate levels are a reliable real-time indicator of the severity and mortality risk of conditions that occur as a result of poor blood circulation and oxygen supply to organs and tissues (hypoperfusion), such as in patients with sepsis, cardiac arrest, stroke, major trauma, cystic fibrosis and other conditions. Lactate levels also... -
FcMBL: Broad-Spectrum Pathogen Capture for Infectious Disease Diagnosis and Therapy
The Problem Infectious diseases have plagued humanity for millennia, and the pathogens that infect and sicken humans are constantly evolving. Severe infections can cause sepsis, a life-threatening condition in which a patient’s immune system overreacts to the infection. The body starts to attack itself, which can lead to tissue damage, organ failure, and death. Sepsis... -
Project Abbie
Over 15 million Americans are at risk of anaphylaxis, a severe allergic reaction triggered by exposure to certain foods, materials, medications, and insect bites. Every three minutes, a food reaction sends someone to the emergency room. In most individuals, anaphylactic shock can be prevented by administering the counteracting drug epinephrine, as soon as an attack... -
Human Organs-on-Chips
Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health. -
Early Detection of Ovarian Cancer
The American Cancer Society estimates that in 2023, approximately 20,000 new cases of ovarian cancer will be diagnosed, and more that 13,000 women will tragically succumb to this devastating disease. Early detection is crucial for improving survival rates, yet ovarian cancer is often diagnosed at advanced stage due to subtle symptoms and a lack of... -
TORCH: Discovering Ovarian Torsion Biomarkers through Proteomics
Ovarian torsion (OT) is a serious medical condition where an ovary twists around the tissue that supports it, which can cut off blood supply to the ovary and sometimes the fallopian tube, causing severe pain. If blood flow is not quickly restored, the ovary might need to be surgically removed. Current diagnostic methods are often... -
Autograph: Multiplex Autoantibody Detection and Monitoring for Women’s Autoimmune Health
Autoimmune diseases disproportionately affect women, with 80% of individuals suffering from these conditions being female. These diseases often lead to chronic and debilitating symptoms. Early and accurate diagnosis is crucial for effective management. Multi-analyte differentiation of protein biomarkers holds immense promise in distinguishing between various autoimmune diseases, enabling tailored treatment plans. To improve patient outcomes,...