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44 Results for 'Blood'
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Technologies 4
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Rapid Metabolite-Sensing System for Blood Lactate
In emergency medicine, blood lactate levels are a reliable real-time indicator of the severity and mortality risk of conditions that occur as a result of poor blood circulation and oxygen supply to organs and tissues (hypoperfusion), such as in patients with sepsis, cardiac arrest, stroke, major trauma, cystic fibrosis and other conditions. Lactate levels also... -
FcMBL: Broad-Spectrum Pathogen Capture for Infectious Disease Diagnosis and Therapy
The Problem Infectious diseases have plagued humanity for millennia, and the pathogens that infect and sicken humans are constantly evolving. Severe infections can cause sepsis, a life-threatening condition in which a patient’s immune system overreacts to the infection. The body starts to attack itself, which can lead to tissue damage, organ failure, and death. Sepsis... -
Targeted EPO: Safely Normalizing Oxygen Delivery in a Broad Range of Disease Conditions
General Biologics commercializes Targeted EPO as a first-in-class fusion protein therapeutic for the treatment of life-threatening and limiting hypoxia in various disease conditions, including COPD, cystic fibrosis, COVID-19, and severe anemias, such as in patients with kidney failure. -
NanoRx: Mechanically-Activated Drug Targeting
The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...
News 30
Multimedia 10
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Audio/PodcastOrgans on Chips: Using Science, Art, and Design to Understand the Human Body – Talking About BloodIn this episode, Wyss Founding Director Don Ingber, M.D., Ph.D., talks with Helen Osborne about: How organ-on-chip and “human body on chips” technologies are built and how they realistically mimic human organ function by combining living cells, blood flow, and mechanical forces like breathing and stretch; The implications of these chips for hematology and clinical... -
Video/AnimationWhat is the future of Engineering with Bioengineering Pioneer Donald E Ingber – Museum of ScienceIs biological inspiration the key to the future of engineering? Bioethicist Insoo Hyun sits down with Donald E. Ingber, Founding Director of the Wyss Institute for Biologically Inspired Engineering and Professor of Bioengineering at Harvard’s School of Engineering & Applied Sciences. Together they explore the profound impact of Nature on engineering beyond the realms of...
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Video/AnimationRapid Triage Test for Active Pulmonary TuberculosisThere’s a large unmet need for accurate, fast, and inexpensive diagnostics for active tuberculosis (ATB), which claims the lives over a million people per year. A team of researchers from the Wyss Institute for Biologically Inspired Engineering, The Broad Institute of Harvard and MIT, Brigham and Women’s Hospital (BWH), and several other collaborating institutions have... -
Video/AnimationShear-Thinning Biomaterial: Catheter InjectionThis movie shows the solid state of the shear-thinning biomaterial immediately after release from the catheter into an aqueous solution (00:04). The STB is cohesive and remains as one solid piece throughout the injection process. There is no noticeable dissolution of the STB into the solution, suggesting it is stable immediately after being discharged from... -
Video/AnimationHuman Organs-On-ChipsWyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer... -
Video/AnimationBioinspired Approach to Sepsis TherapyWyss Institute Founding Director Don Ingber, Senior Staff Scientist Michael Super and Technology Development Fellow Joo Kang explain how they engineered the Mannose-binding lectin (MBL) protein to bind to a wide range of sepsis-causing pathogens and then safely remove the pathogens from the bloodstream using a novel microfluidic spleen-like device. Credit: Wyss Institute at Harvard...