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Technologies 5

• DNA Nanoswitch Calipers for Single-Molecule Proteomics
  DNA nanoswitch calipers are a first-of-their-kind research tool that leverage DNA’s unique molecular qualities to study post-translational modifications on proteins to unlock a new frontier of medicine.
• DNA Nanoswitches: “Lab-on-a-Molecule” Drug Discovery
  The Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions.
• Project Abbie
  Over 15 million Americans are at risk of anaphylaxis, a severe allergic reaction triggered by exposure to certain foods, materials, medications, and insect bites. Every three minutes, a food reaction sends someone to the emergency room. In most individuals, anaphylactic shock can be prevented by administering the counteracting drug epinephrine, as soon as an attack...
• Multiplexed Molecular Force Spectroscopy
  Programmable DNA nanoswitches, invented at the Wyss Institute, can now be used in combination with a benchtop Centrifuge Force Microscope (CFM) as a highly reliable tool to observe thousands of individual molecules and their responses to mechanical forces in parallel. By analyzing the responses of single molecules under conditions where they experience such forces, it is possible...
• Flexi-Mitts: Neuromoter and Cognitive Ability Tracker
  Advances in medical care have improved the survival of very low birth weight premature infants but at the same time have also led to an increased number of surviving infants with reduced cerebral growth and long-term neurodevelopmental motor, cognitive, and social morbidities. These complications are met by a lack of early assessment tools for diagnosing...

News 22

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• Press Release
  
  Shining a light on the hidden damage of mild brain injuries
  January 3, 2024
• Press Release
  
  Human Lung Chip leveraged to faithfully model radiation-induced lung injury
  October 17, 2023
• Press Release
  
  Wyss Institute’s Lab-on-a-Molecule Drug Discovery Project Receives Funding from Northpond Labs
  April 4, 2023

Multimedia 3

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  Video/Animation
  DNA Nanoswitch Calipers
  The world’s tiniest ruler for biomolecules has been created by researchers at the Wyss Institute at Harvard University, Harvard Medical School, and Boston Children’s Hospital. DNA Nanoswitch Calipers can measure very small peptides to better understand their structure and function, and enable them to be quickly identified in mixed samples. These insights could lead to...

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  Video/Animation
  miSherlock – Detecting COVID-19 Variants from Saliva
  Despite increasing vaccination rates, new, more-infectious variants of SARS-CoV-2 could prolong the COVID-19 pandemic. Researchers at the Wyss Institute at Harvard University and MIT have created a low-cost, CRISPR-based diagnostic platform that can detect SARS-CoV-2 variants in a patient’s saliva without the need for any additional equipment. The team hopes their device will enable more...

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  Video/Animation
  Project ABBIE
  Project ABBIE is inspired by the story of Abbie Benford, who succumbed to complications related to anaphylaxis just eight days before her 16th birthday. The Wyss Institute, in collaboration with Boston Children’s Hospital, is developing a wearable, non-invasive device that could sense anaphylaxis and automatically inject epinephrine in individuals who are unable to do so...