Search results

Technologies 9

View all

• Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More
  Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more.
• Soft hydrogel electrodes for better, safer implants
  Soft, conductive hydrogels match the physical properties of the human brain, enabling the creation of electrodes and implantable devices that can improve brain-machine interfaces while reducing the risk of injury.
• CogniXense for Rare Disease Drug Discovery
  Unravel Biosciences has licensed a Wyss drug discovery platform technology to identify and create drugs to treat complex central nervous system disorders, starting with Rett syndrome.
• CircaVent: A Drug Discovery Platform for Mental Health Conditions
  CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder.
• CogniXense: A Platform for Rapid Drug Repurposing
  CogniXense is a target-agnostic drug discovery platform that enables the repurposing of drugs for rare genetic diseases in record time. By combining human data-based computational drug prediction with on-demand animal model development, we can mimic the diversity of symptoms of patient populations and begin drug screening on new diseases within a month.
• Engineered Brain Organoids
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

Collaborations 4

• Brain Targeted Therapeutic Collaboration
  Combine our shuttles with your drugs to create new brain targeted therapeutics for patients.
• Brain Shuttle Research Sponsorship & Licensing
  Enabling brain-targeted drug development through non-exclusive licensing and pre-competitive research sponsorship.
• Bridging the Funding Gap for Brain Therapeutics
  A unique opportunity to help develop a new generation of brain targeted drugs
• Wyss Brain Targeting Program
  Advancing brain delivery approaches that enable more safe and effective brain-targeted therapeutics.

News 35

View all

• Press Release
  
  Closing in on Parkinson’s Disease proteins in extracellular vesicles in the blood
  November 1, 2024
• Community
  
  Vinny Chandran Suja on Making Backpacks More Reliable and Predictable
  August 20, 2024
• Press Release
  
  Wyss Institute promotes Natalie Artzi to its Core Faculty and appoints Di Feng as an Associate Faculty member
  August 12, 2024

Multimedia 7

View all

• 

  Video/Animation
  Atlantic Health Research Spotlight: Finding Balance in Bipolar Disorder Through Drug Prediction and Organoid-Based Drug Screening
  Innovation has disrupted care as we know it. Challenges with access, complex diseases, and care delivery persist, but so do areas of opportunity for emerging tech and discoveries. The Atlantic explored gene editing, artificial intelligence, climate change, weight-loss and diabetes treatments, and more at their Annual Health Summit. The Wyss’ Director of Synthetic Biology, Jenny...

• 

  Video/Animation
  How can we better treat brain diseases?
  The Brain Targeting Program at the Wyss Institute is a pre-competitive, multi-partner industry collaboration that aims to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University

• 

  Audio/Podcast
  Can we grow a conscious brain? – CrowdScience
  Philosophers have long pondered the concept of a brain in a jar, hooked up to a simulated world. Though this has largely remained a thought experiment, CrowdScience listener JP wants to know if it might become reality in the not-too-distant future, with advances in stem cell research. In the two decades since stem cell research...

• 

  Video/Animation
  Wyss Institute Brain Targeting Program
  This animation explains how Wyss Institute researchers and their industry partners aim to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University.

• 

  Video/Animation
  CogniXense: Speeding Up Treatments for Rare Diseases
  At the Wyss Institute, we are tackling Rett syndrome, a rare disease that affects 1 out of 9,000 children, by developing a scalable model for neurodevelopmental and cognitive diseases. This model can test drugs to see which will improve memory, learning, and behavior, with the end goal of finding effective therapies. Credit: Wyss Institute at...

• 

  Video/Animation
  This is Your Brain on Chips
  How do you study something as complex as the human brain? Take it apart. Wyss researchers have created Organ Chips that mimic the blood-brain barrier and the brain and, by linking them together, discovered how our blood vessels and our neurons influence each other. Credit: Wyss Institute at Harvard University