Technologies search results
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Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More
Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more. -
Soft hydrogel electrodes for better, safer implants
Soft, conductive hydrogels match the physical properties of the human brain, enabling the creation of electrodes and implantable devices that can improve brain-machine interfaces while reducing the risk of injury. -
CogniXense for Rare Disease Drug Discovery
Unravel Biosciences has licensed a Wyss drug discovery platform technology to identify and create drugs to treat complex central nervous system disorders, starting with Rett syndrome. -
CircaVent: A Drug Discovery Platform for Mental Health Conditions
CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder. -
CogniXense: A Platform for Rapid Drug Repurposing
CogniXense is a target-agnostic drug discovery platform that enables the repurposing of drugs for rare genetic diseases in record time. By combining human data-based computational drug prediction with on-demand animal model development, we can mimic the diversity of symptoms of patient populations and begin drug screening on new diseases within a month. -
Engineered Brain Organoids
The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of... -
Treating Breast Cancer that Metastasizes to the Brain
Treating breast cancer that has metastasized to the brain is an extreme challenge because most drugs are not able to cross the blood-brain barrier (BBB). About one in three patients with HER2+ or triple negative breast cancer will develop brain metastases, which leads to high morbidity and mortalities. There is currently no effective, systemic treatment... -
Vagina-Brain Axis: Treating Hormone Imbalance-Related Diseases
Microbes in our gut have been shown to impact the brain, which is the control center for most of the body’s functions. Research shows that the gut microbiome affects our mood and mental health, including depression. This regulation is called the gut-brain axis. Other organs beyond the gut — including those in the female genital... -
Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness that disproportionately affects women, causing severe fatigue, cognitive difficulties, sleeping problems, dizziness, and pain. Currently, no treatment exists for ME/CFS. Our team is creating accurate disease models to study brain activity, with the aim of understanding if ME/CFS is caused by continuous activation of interconnected brain...