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Technologies 3

• DoriVac: Boosting Antigen-specific Immune Responses with DNA Origami-Based Vaccines
  Personalized cancer and infectious disease vaccine platform harnessing DNA nanotechnology to control the co-delivery and co-presentation of tumor antigen and adjuvant ligands to immune cells with nanoscale precision. This approach has potential to trigger enhanced immune responses against tumors and infectious pathogens.
• Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics
  This nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers.
• Implantable Cancer Vaccine
  The implantable cancer vaccine is an aspirin-sized disc that is implanted under the skin and serves as an artificial lymph node, recruiting and training a patient's own immune cells to find and kill their cancer cells. It was validated in a Phase I clinical trial at the Wyss Institute, and is currently being developed by Novartis to treat melanoma.

Collaborations 1

• i3 Center: Biomaterials to Create T Cell Immunity
  Cancer immunologists and biological engineers are developing new biomaterials-based approaches to develop new anti-cancer immunotherapies for treatment-resistant cancers.

News 12

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• Press Release
  
  Deconstructing the mechanics of bone marrow disease
  July 11, 2022
• Research Spotlights
  
  New cancer vaccine delivers double punch to tumors
  May 27, 2022
• Research Spotlights
  
  “Immuno-engineering to Improve Immunotherapy” (i3) Center at Harvard University selects Dana-Farber cancer-immunologist Rizwan Romee as its 2021 grant recipient
  December 13, 2021

Multimedia 3

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  Video/Animation
  DoriVac: Square Block DNA Origami Vaccine
  This animation explains how DoriVac leverages DNA origami nanotechnology and immune activators to stimulate stronger and long-lasting immune responses against cancer and potentially infectious diseases. Credit: Wyss Institute at Harvard University

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  Audio/Podcast
  Disruptive: Cancer Vaccine & Hydrogel Drug Delivery
  In this episode of Disruptive, Wyss Founding Core Faculty Member Dave Mooney discusses programmable nanomaterials approaches to fighting disease. Mooney explains how a cancer vaccine, developed by his team and currently in a clinical trial at the Dana-Farber Cancer Institute, can train one’s own immune system to target specific cancer cells. He also describes the...

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  Video/Animation
  Introduction to Implantable Cancer Vaccine
  What if we could prevent and treat cancer with a simple vaccine? Credit: Wyss Institute at Harvard University