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148 Results for 'Disease Model'
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Technologies 7
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PhonoGraft: 3D Printed Tympanic Membrane Graft
Perforations of the tympanic membrane or “eardrum,” the thin membrane that conducts sound in the ear, can result in severe hearing loss and recurring infections. Worldwide, tympanic membrane perforations occur in about 30 million people, with about four million people in North America and the European Union alone, due to blast and other traumatic injuries,... -
Bone Marrow-Like Scaffolds for Accelerating Immune Reconstitution
Bone marrow transplants containing hematopoietic stem cells from an immune-compatible (“allogeneic”) donor can cure patients with otherwise fatal blood disorders including multiple myeloma and leukemias by reconstituting their entire immune systems after chemotherapy. However, following such a “hematopoietic stem cell transplantation” (HSCT), the restoration of T cell immunity – which depends on the production of... -
Brain Targeting Program: Shuttles for Brain Delivery of Therapeutics and Diagnostics
In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain. Leveraging the human blood-brain barrier (BBB) Chip technology developed by Ingber’s team, combined with advanced antibody R&D capabilities, the... -
Liquid-Infused Tympanostomy Tubes
Acute middle ear infections affect more than 700 million people each year, with children often experiencing the most recurrent and severe symptoms due to their underdeveloped physiology. By the age of three, 25-40 % of children have had at least three episodes of acute middle ear infection, which is commonly accompanied by excess fluids accumulating... -
CogniXense: Target-Agnostic Drug Repurposing in Record Time
The problem There are more than 7,000 known rare genetic diseases that collectively afflict more patients in the United States than diabetes, but only 5% of these diseases have any effective treatment. A major driver of this lack of therapies is that about 75% of rare genetic diseases cause cognitive and behavioral impairment, which are... -
FcMBL: Broad-Spectrum Pathogen Capture for Infectious Diseases
Microbial infection is the cause of life-threatening cases of sepsis, meningitis and multiple other diseases that are major causes of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of dangerous microbes must be confirmed, and when they are found, they need to be removed,...
News 118
Multimedia 23
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Video/AnimationPhonoGraft: Programming the eardrum to repair itselfEardrum perforations are a widespread problem affecting millions worldwide. Current standard of care is invasive, involves harvesting an autologous tissue to patch the eardrum, and often requires to revision surgeries, while hearing outcomes remain unsatisfying. What if we could program the eardrum to repair itself after injury? Researchers at the Wyss Institute, Massachusetts Eye and... -
Video/AnimationBeating Back the CoronavirusWhen the coronavirus pandemic forced Harvard University to ramp down almost all on-site operations, members of the Wyss Institute community refocused their teams, and formed new ones, in order to fight COVID-19 on its multiple fronts. These efforts include building new pieces of personal protective equipment that were delivered to frontline healthcare workers, developing new... -
Video/AnimationCogniXense: Speeding Up Treatments for Rare DiseasesAt the Wyss Institute, we are tackling Rett syndrome, a rare disease that affects 1 out of 9,000 children, by developing a scalable model for neurodevelopmental and cognitive diseases. This model can test drugs to see which will improve memory, learning, and behavior, with the end goal of finding effective therapies. Credit: Wyss Institute at... -
Video/AnimationA Swifter Way Towards 3D-printed Organs20 people die waiting for an organ transplant every day in the US, but lab-grown organs so far lack the cellular density and functions required to make them viable replacements. The new SWIFT method from the Wyss Institute and Harvard SEAS solves those problems by 3D printing vascular channel networks directly into living tissue constructs,... -
Video/AnimationLiquid-Infused Tympanostomy TubesResearchers at the Wyss Institute have developed next-generation tympanostomy tubes with an innovative material design that significantly reduces biofouling, implant size, need for revision surgeries, and promotes drug delivery into the middle ear. Credit: Wyss Institute at Harvard University -
Video/AnimationKidney Organiods: Flow-Enhanced Vascularization and Maturation In VitroThis video explains how the collaborative project created vascularized kidney organoids and how they advance the field of tissue engineering. Credit: Wyss Institute at Harvard University.