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87 Results for 'Disease Model'
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Technologies 3
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AAV-Engineering For Advanced Gene Therapy
Gene therapy with AAV (adeno-associated virus) as a delivery vehicle is a leading therapeutic modality for genetic disorders that is approved in Europe for the metabolic disease Familial Lipoprotein Lipase Deficiency. It is currently being tested in clinical trials in the U.S. to treat other rare conditions like the retinal Leber Congenital Amaurosis and the... -
Pathogen Capture Technology for Infectious Disease Therapeutics and Diagnostics
Microbial contamination is the cause of life-threatening cases of sepsis, meningitis and multiple other infectious diseases that are a major cause of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of microbial contaminants must be confirmed, and when they are found, they need to... -
Human Organs-on-Chips
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to...
News 68
Multimedia 16
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Video/AnimationPodocyte Cells: Kidney-on-a-ChipThis video shows a 3-dimensional rendering of the glomerulus-on-a-chip with human stem cell-derived mature podocytes (in green) grown and differentiated in one channel (shown on top) and that extend their processes through the modeled glomerulus basement membrane towards glomerular vascular cells (in magenta) in the parallel running channel (shown on the bottom). Credit: Wyss Institute... -
Video/Animation3D Printed Heart-on-a-ChipIn this video, learn how Wyss Institute and Harvard SEAS researchers have created a 3D-printed heart-on-a-chip that could lead to new customizable devices for short-term and long-term in vitro testing. Credit: Johan U. Lind (Disease Biophysics Group), Alex D. Valentine and Lori K. Sanders (Lewis Lab)/Harvard University -
Video/AnimationSmoking Human Lung Small Airway-on-a-ChipIn this video, Wyss Founding Director Donald Ingber and Technology Development Fellow Kambez Benam explain how the integrated smoking device mimics normal cigarette smoke exposure and how it can impact research into the causes of COPD and into new biomarkers and therapeutics. Credit: Wyss Institute at Harvard University -
Video/AnimationBioprinting: The Kidney’s Proximal TubulesIn this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. Credit: Wyss Institute at Harvard University -
Video/AnimationSmall Airway-on-a-Chip: Modeling COPD and AsthmaDevelopment of new therapeutics for chronic lung diseases have been hindered by the inability to study them in vitro. To address this challenge, Wyss Institute researchers used their Organ-on-a-Chip technology to produce a microfluidic ‘human lung small airway-on-a-chip.’ The device, which is composed a clear rubber material, is lined by living Human lung small airway... -
Video/AnimationPathogen-Extracting Sepsis TherapyThis video explains how sepsis induced by an overload of blood pathogens can be treated with the Wyss Institute’s improved pathogen-extracting, spleen-mimicking device. Blood is flown through a cartridge filled with hollow fibers that are coated with a genetically engineered blood protein inspired by a naturally-occurring human molecule called Mannose Binding Lectin (MBL). MBL is...