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• Fistula Repair: Minimally-Invasive Repair of Obstetric Fistula
  Obstetric fistula is a devastating condition characterized by an abnormal connection between the female genital tract and the bladder or rectum. It affects more than two million women in Africa and Asia and leads to constant leakage of blood, urine, and stool, causing pain, infection, social ostracization, and physical isolation. Current treatment through reconstructive surgery...
• Vagina-Brain Axis: Treating Hormone Imbalance-Related Diseases
  Microbes in our gut have been shown to impact the brain, which is the control center for most of the body’s functions. Research shows that the gut microbiome affects our mood and mental health, including depression. This regulation is called the gut-brain axis. Other organs beyond the gut — including those in the female genital...
• FernScore: Diagnosing bacterial vaginosis for reproductive health
  Vaginal infections, especially bacterial vaginosis (BV), are a major concern for women’s health. Current diagnosis methods are subjective and often miss the mark, particularly for asymptomatic women. Researchers have developed a promising new approach using a test that analyzes the fern-like patterns formed when cervical mucus dries on a slide. Healthy mucus forms distinct fern...
• Personalized Contraception
  The burden of contraception falls predominantly on women, often causes unpleasant side effects, and can fail if not strictly adhered to. We envision a contraceptive approach that is immediate, non-surgical, reversible, and accessible to both women and men. We’re developing a platform that uses hydrogel “bioblocks” for minimally invasive contraceptive implants, which could allow for...
• Stroma Tx: Safe Pregnancy for IBD Patients
  Patients with Inflammatory Bowel Disease (IBD) are advised to achieve remission before pregnancy, in an effort to decrease pregnancy-related intestinal issues, including fibrosis. Yet the exact mechanisms underlying the fluctuation of their symptoms remain unclear and there are no treatments currently available. To close this knowledge gap, we are treating our IBD Organ Chips with...
• Lymphatics Medicines for Female Health
  Lymphedema is a painful condition affecting millions of women worldwide, often caused by surgical treatment of breast and gynecologic cancers, or a biological predisposition. While no medicines are currently available to address lymphatic disease, we are combining a bioengineered human lymphatic-on-chip platform, lymphatic cell biology, and drug development expertise in an interdisciplinary effort to transform...