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Technologies 5

• Fistula Repair: Minimally-Invasive Repair of Obstetric Fistula
  Obstetric fistula is a devastating condition characterized by an abnormal connection between the female genital tract and the bladder or rectum. It affects more than two million women in Africa and Asia and leads to constant leakage of blood, urine, and stool, causing pain, infection, social ostracization, and physical isolation. Current treatment through reconstructive surgery...
• Stroma Tx: Safe Pregnancy for IBD Patients
  Patients with Inflammatory Bowel Disease (IBD) are advised to achieve remission before pregnancy, in an effort to decrease pregnancy-related intestinal issues, including fibrosis. Yet the exact mechanisms underlying the fluctuation of their symptoms remain unclear and there are no treatments currently available. To close this knowledge gap, we are treating our IBD Organ Chips with...
• Lymphatics Medicines for Female Health
  Lymphedema is a painful condition affecting millions of women worldwide, often caused by surgical treatment of breast and gynecologic cancers, or a biological predisposition. While no medicines are currently available to address lymphatic disease, we are combining a bioengineered human lymphatic-on-chip platform, lymphatic cell biology, and drug development expertise in an interdisciplinary effort to transform...
• iNodes: Implantable Lymphoid Organs for Ovarian Cancer Therapy
  Over 12,000 women die of ovarian cancer every year, yet ovarian cancer receives less than 1% of research funding compared to other solid tumors. Early symptoms can often mimic less serious conditions, and delayed diagnoses mean that 80% of ovarian cancer cases are metastatic at the time of detection. For these patients, the 5-year survival...
• Physiological Mucus-producing Organ-on-a-Chip Model of Human Cervix for Analysis of Host-microbiome Contributions to Vaginal Health
  Interactions between a woman’s microbiome and the microenvironment of the reproductive tract are crucial for vaginal health. Disruptions of the microbial balance can lead to conditions like HIV, bacterial vaginosis, miscarriage and preterm birth. Yet current research methods, such as microbial cultures and metagenomic analysis, often fail to replicate the cervicovaginal environment accurately. Our Cervix...