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159 Results for 'Fundamental Research'
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Technologies 9
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CircaVent: A Drug Discovery Platform for Mental Health Conditions
CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder. -
OrbitSeq: A Collaborative Digital Hub for Life Sciences Data
OrbitSeq is a digital platform that empowers life sciences researchers to browse, upload, and analyze datasets, and easily collaborate with each other to bring science closer together and speed up the pace of discovery. -
DNA Nanotechnology Tools: From Design to Applications
A suite of diverse, multifunctional DNA nanotechnological tools with unique capabilities and potential for a broad range of clinical and biomedical research areas. Our DNA nanotechnology devices were engineered to overcome specific bottlenecks in the development of new therapies and diagnostics, and to help further our understanding of molecular structures. -
Synthetic AAV Capsids for Advanced Gene Therapy
The protein shell (capsid) of Adeno-associated viruses (AAV) are presently the most promising delivery vehicles for various in vivo gene therapies. AAVs are non-pathogenic and, through past engineering efforts, have become safe due to their inability to integrate into and damage the genome of target cells. Rather, the delivered DNA containing a therapeutic gene of... -
Toehold Switches for Synthetic Biology
The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices... -
Toehold Probes for Nucleic Acid Detection
The accurate detection of specific DNA or RNA sequences is important for many research and diagnostic applications, and unspecific detection of similar sequences that can differ by only a single nucleotide can give false positive results. In addition, researchers and clinicians would like to accurately test for presence or absence of multiple single base changes...
Collaborations 1
Brain Targeting ProgramNews 116
Multimedia 33
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Video/AnimationFrontier Science #10: Bioelectrics w/ Michael LevinMichael Levin, a Wyss Associate Faculty member and a Distinguished Professor in the Biology department at Tufts, holds the Vannevar Bush endowed Chair and serves as director of the Allen Discovery Center at Tufts and the Tufts Center for Regenerative and Developmental Biology. Recent honors include the Scientist of Vision award and the Distinguished Scholar... -
Video/AnimationXenobots 3.0: Living Robots That Can ReproduceOn Wednesday, December 1, 2021, the scientists behind the Xenobots participated in a live webinar to discuss their research. The panel consisted of Associate Faculty member Mike Levin Ph.D., Sam Kriegman Ph.D., Josh Bongard Ph.D., and Doug Blackiston Ph.D. Answers to the many audience questions asked during the webinar that panelists did not have time... -
Video/AnimationDNA Nanoswitch CalipersThe world’s tiniest ruler for biomolecules has been created by researchers at the Wyss Institute at Harvard University, Harvard Medical School, and Boston Children’s Hospital. DNA Nanoswitch Calipers can measure very small peptides to better understand their structure and function, and enable them to be quickly identified in mixed samples. These insights could lead to... -
Video/AnimationStudying Pyrosome BioluminescencePyrosomes are one of the few organisms known to exhibit bioluminescence in response to light. They are also very delicate, which makes them difficult to study. Scientists from the Wyss Institute have collaborated with marine biologists to create a soft robot that delicately handles pyrosomes so that they can be studied safely. Recently, the robot... -
Video/AnimationSoft Robotic Gripper for JellyfishIn order to study jellyfish and other fragile marine life without damaging them, researchers at the Wyss Institute and Baruch College developed an ultra-soft gripper to gently grasp jellyfish and release them without harm. Credit: Wyss Institute at Harvard University -
Video/AnimationLighting up proteins with Immuno-SABERThis animation explains how Immuno-SABER uses the Primer Exchange Reaction (PER) to enable the simultaneous visualization of multiple proteins in tissues in different applications. Credit: Wyss Institute at Harvard University.