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Technologies 2

• MRBL: Next-Generation Gene Therapy for Molecular Skin Rejuvenation
  The skin is the largest organ in the body, and carries out multiple vital functions, including protective barrier functions against the loss of moisture and mechanical, UV and other injuries, immune defense functions, as well as sensory functions. For maintaining its integrity and multifaceted performances, skin relies on a range of different cell types that...
• Synthetic AAV Capsids for Advanced Gene Therapy
  The protein shell (capsid) of Adeno-associated viruses (AAV) are presently the most promising delivery vehicles for various in vivo gene therapies. AAVs are non-pathogenic and, through past engineering efforts, have become safe due to their inability to integrate into and damage the genome of target cells. Rather, the delivered DNA containing a therapeutic gene of...

News 10

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• Press Release
  
  Machine-learning how to create better AAV gene delivery vehicles
  February 11, 2021
• Press Release
  
  A new vision for AAV-delivered gene therapies
  February 10, 2021
• Translation News
  
  Rejuvenate Bio launches to help dogs live longer, healthier lives
  February 6, 2020

Multimedia 2

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  Video/Animation
  Improving Canine Healthspan
  A Wyss Institute technology that can treat multiple age-related diseases is now being developed by Rejuvenate Bio into a treatment for mitral valve disease and other deadly conditions in dogs, with the goal of helping man’s best friend live longer, healthier lives. Credit: Wyss Institute at Harvard University

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  Video/Animation
  AAV Capsid Engineering
  Wyss researchers have created a high-throughput platform to generate an Adeno-associated virus 2 (AAV2) library containing 200,000 variants, each carrying a distinct mutation in the virus capsid protein. Their analysis identified capsid changes that enhanced “homing” potential to specific organs in mice and virus viability, as well as a new protein hidden in the capsid-encoding...