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Technologies 1

• Synthetic AAV Capsids for Advanced Gene Therapy
  The protein shell (capsid) of Adeno-associated viruses (AAV) are presently the most promising delivery vehicles for various in vivo gene therapies. AAVs are non-pathogenic and, through past engineering efforts, have become safe due to their inability to integrate into and damage the genome of target cells. Rather, the delivered DNA containing a therapeutic gene of...

News 8

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• Translation News Rejuvenate Bio launches to help dogs live longer, healthier lives
  February 6, 2020
• Press Release A lifeline for leaky lung cells
  December 2, 2019
• Press Release Wyss Institute researchers demonstrate machine-guided engineering of AAV capsids for gene therapy
  November 28, 2019

Multimedia 2

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  Video/Animation
  Improving Canine Healthspan
  A Wyss Institute technology that can treat multiple age-related diseases is now being developed by Rejuvenate Bio into a treatment for mitral valve disease and other deadly conditions in dogs, with the goal of helping man’s best friend live longer, healthier lives. Credit: Wyss Institute at Harvard University

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  Video/Animation
  AAV Capsid Engineering
  Wyss researchers have created a high-throughput platform to generate an Adeno-associated virus 2 (AAV2) library containing 200,000 variants, each carrying a distinct mutation in the virus capsid protein. Their analysis identified capsid changes that enhanced “homing” potential to specific organs in mice and virus viability, as well as a new protein hidden in the capsid-encoding...