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News 14

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• Press Release
  
  A new tool for studying COVID’s impact on gut health
  November 8, 2021
• Press Release
  
  Of mice and men and leveraging their different tolerance to pathogens
  March 15, 2021
• Research Spotlights
  
  Don’t hate your guts – heal them
  February 10, 2020

Multimedia 4

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  Video/Animation
  How do we make safer and more effective drugs?
  Wyss researchers are using an ever-growing number of human tissue-mimicking Organ Chips to improve and accelerate the drug development process for a wide number of unmet diseases – and understand what causes them to erupt. More recently, they added a human Vagina Chip and personalized Barrett’s esophagus Chip to their arsenal, and created in vitro...

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  Video/Animation
  Mucus Layer In Vitro on Human Colon Chip
  Using Human Organ Chips, researchers at the Wyss Institute were able to generate the mucus layer of the colon in vitro, which has never been done before. In the colon, the mucus layer protects intestinal epithelial cells against inflammatory stimuli such as pathogens, damaged cells, or irritants. The ability to support mucus-producing cells is one...

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  Video/Animation
  Interrogator: Human Organ-on-Chips
  This video describes the “Interrogator” instrument that can be programmed to culture up to 10 different Organ Chips and sequentially transfer fluids between their vascular channels to mimic normal human blood flow between the different organs of our body. Its integrated microscope enables the continuous monitoring of the tissues’ integrities in the individual organ chips...

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  Video/Animation
  Gastrointestinal Re-Programming
  In this animation, see an example of how genetically engineered microbes being developed by researchers at the Wyss Institute could detect and treat a wide range of gastrointestinal illnesses and conditions. Credit: Wyss Institute at Harvard University