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Video/AnimationHow can we train the immune system to fight cancer?The implantable cancer vaccine is a biomaterial that recruits and reprograms a patient’s own immune cells on-site to kill cancer cells. This revolutionary immuno-material technology was tested in a Phase I clinical trial with promising results and is currently licensed by Novartis as an immunotherapy to treat specific tumor types. Credit: Wyss Institute at Harvard... -
Video/AnimationMetabolic T cell Labeling: simple and effective enhancement of therapeutic T cells with immune-stimulating cytokinesThis animation shows how the surface of patient-derived T cells is metabolically labeled with azido-sugar molecules that then can be used to attach immune-enhancing cytokines with the help of click chemistry. The approach could help expand adoptive T cell therapies to treatment of solid tumors. Credit: Wyss Institute at Harvard University -
Video/AnimationEliminating brain cancer at its source | Natalie Artzi | TEDxMITGlioblastoma is a lethal, aggressive brain cancer with a dismal median overall survival rate of 15 months, a number that has remained unchanged for decades. Treatment for this devastating disease involves surgical resection followed by chemotherapy and radiation therapy; however, tumor recurrence is inevitable as it is impossible to eliminate all tumor cells with current... -
Video/AnimationSomaCode: GPS for Cell TherapyJust like zip codes help drivers navigate to specific addresses using a GPS system, the molecular ‘zip codes’ identified via the SomaCode platform can be used to deliver cell therapies to their specific targets in the human body, increasing the therapies’ efficacy and reducing side effects. Credit: Wyss Institute at Harvard University -
Audio/PodcastImmunoengineering with Dave Mooney – BIOS PodcastWyss Core Faculty member Dave Mooney is a leader in the fields of biomaterials, mechanotransduction, drug delivery, tissue engineering and immunoengineering. He is interested in understanding how cells sense signals in their environment and how this alters cell behavior. His laboratory develops biomaterials that exploit these signals to regulate specific cells and their function. They... -
Video/AnimationOMNIVAX: Infection Vaccine PlatformThis video explains how OMNIVAX – an immuno-material-based vaccine technology can be used to rapidly create injectable vaccines against diverse viral and bacterial pathogens, and how the platform is used by the team to develop a vaccine against recurring urinary tract infections (UTIs) in their lead human application. Credit: Wyss Institute at Harvard University. -
Audio/PodcastDisruptive: Cancer Vaccine and Immuno-MaterialsImmunotherapy – treatment that uses the body’s own immune system to help fight disease – has groundbreaking and life-saving implications. In an effort to make immunotherapy more effective, Wyss Institute researchers are developing new immuno-materials, which help modulate immune cells to treat or diagnose disease. In this episode of Disruptive, Dave Mooney, Wyss Core Faculty... -
Video/AnimationWyss Focus: Immuno-MaterialsWyss Core Faculty, Dave Mooney, explains our new Immuno-Materials Focus Area, which adds a new dimension to immunotherapy in that it harnesses materials to make treatments more efficient and effective. These material-based systems are capable of modulating immune cells and releasing them into the body where they can treat diseases. -
Audio/PodcastDavid and Mary Mooney: Seeing Is Believing-Therapeutic Cancer VaccinesWyss Core Faculty member David Mooney presents a talk with Mary Mooney, titled Seeing Is Believing: Therapeutic Cancer Vaccines. Marshalling a patient’s immune system to recognize and destroy cancerous cells is an exciting strategy to attack cancer, and this talk will explore materials that engage the immune system through science and artistic representation. Mary K.... -
Video/AnimationArtScience Talks @ Le Lab – Seeing Is Believing: Therapeutic Cancer VaccinesWyss Core Faculty member David Mooney presents a talk with Mary Mooney, titled Seeing Is Believing: Therapeutic Cancer Vaccines. Marshaling a patientÍs immune system to recognize and destroy cancerous cells is an exciting strategy to attack cancer, and this talk will explore materials that engage the immune system through science and artistic representation. Mary K.... -
Audio/PodcastWilliam Shih: Lego-Style Construction of Future Therapeutics From DNAListen to Wyss Core Faculty member William Shih’s lecture on how custom molecular shapes can be designed using DNA building blocks and how these minuscule devices could have a profound impact on fields ranging from molecular biophysics to therapeutics to nano-optics for decades to come. Shih’s lecture is part of the ArtScience lecture series at...
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Audio/PodcastDisruptive: Molecular RoboticsHow can DNA be programmed to build novel structures, devices, and robots? We have taken our understanding of DNA to another level, beginning to take advantage of some of DNA’s properties that have served nature so well, but in ways nature itself may have never pursued. Humans can now use DNA as a medium for... -
Video/AnimationSmall Airway-on-a-Chip: Modeling COPD and AsthmaDevelopment of new therapeutics for chronic lung diseases have been hindered by the inability to study them in vitro. To address this challenge, Wyss Institute researchers used their Organ-on-a-Chip technology to produce a microfluidic ‘human lung small airway-on-a-chip.’ The device, which is composed a clear rubber material, is lined by living Human lung small airway... -
Audio/PodcastDisruptive: Cancer Vaccine & Hydrogel Drug DeliveryIn this episode of Disruptive, Wyss Founding Core Faculty Member Dave Mooney discusses programmable nanomaterials approaches to fighting disease. Mooney explains how a cancer vaccine, developed by his team and currently in a clinical trial at the Dana-Farber Cancer Institute, can train one’s own immune system to target specific cancer cells. He also describes the... -
Video/AnimationGastrointestinal Re-ProgrammingIn this animation, see an example of how genetically engineered microbes being developed by researchers at the Wyss Institute could detect and treat a wide range of gastrointestinal illnesses and conditions. Credit: Wyss Institute at Harvard University -
Video/AnimationVirus-inspired DNA NanodevicesWyss Institute Core Faculty member William Shih and Technology Development Fellow Steven Perrault explain why DNA nanodevices need protection inside the body, and how a viral-inspired strategy helps protect them. Credit: Wyss Institute at Harvard University -
Video/AnimationDNA Nanorobot: Cell-Targeted, Payload-DeliveringThis video describes a cell-targeted, payload-delivering DNA nanorobot developed at the Wyss Institute that can trigger targeted therapeutic responses. This novel technology could potentially seek out cancer cells and cause them to self-destruct. Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Programmable NanoroboticsWhat if we could build programmable nanorobots to attack disease? Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Implantable Cancer VaccineWhat if we could prevent and treat cancer with a simple vaccine? Credit: Wyss Institute at Harvard University