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Technologies 1

• abbieSense: Anaphylaxis Diagnostic
  The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately...

News 23

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• Awards
  
  Wyss Institute at Harvard University wins BARDA contract to leverage human Organ Chips to advance knowledge and drug discovery for broad range of health security threats
  October 18, 2023
• Press Release
  
  Human Lung Chip leveraged to faithfully model radiation-induced lung injury
  October 17, 2023
• Press Release
  
  Fighting viruses is as easy as breathing
  April 8, 2022

Multimedia 7

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  Audio/Podcast
  Animal Free Labcast #4 – The Pioneer
  World-class pioneer of biomedical research and innovation, Dr. Don Ingber, is the founding director of Harvard University’s Wyss Institute for Biologically Inspired Engineering. In 2010, Dr. Ingber developed a lung-on-a-chip – the first of its kind – and has continued to lead the field by developing numerous other organ chip models, demonstrating their ability to...

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  Audio/Podcast
  Preventing the Next Pandemic with Organ Chips
  In search for strategies to curb pandemics, scientists strive to understand how pathogens slip past the immune system and wreak havoc on the body. To achieve this goal, researchers study viral infection in models that mimic how different cell types interact with each other, the immune system, or the environment. Organ-on-a-chip models combine tissue engineering...

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  Video/Animation
  Beating Back the Coronavirus: FDA-Approved Drug Repurposing Pipeline
  With the goal of rapidly repurposing FDA-approved drugs to treat COVID-19, the Wyss Institute is collaborating with the Frieman Lab at the University of Maryland Medical School and the tenOever Lab at the Icahn School of Medicine at Mount Sinai to establish a multidisciplinary pipeline that can rapidly predict, test, and validate potential treatments. Credit:...

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  Video/Animation
  Smoking Human Lung Small Airway-on-a-Chip
  In this video, Wyss Founding Director Donald Ingber and Technology Development Fellow Kambez Benam explain how the integrated smoking device mimics normal cigarette smoke exposure and how it can impact research into the causes of COPD and into new biomarkers and therapeutics. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Small Airway-on-a-Chip: Modeling COPD and Asthma
  Development of new therapeutics for chronic lung diseases have been hindered by the inability to study them in vitro. To address this challenge, Wyss Institute researchers used their Organ-on-a-Chip technology to produce a microfluidic ‘human lung small airway-on-a-chip.’ The device, which is composed a clear rubber material, is lined by living Human lung small airway...

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  Video/Animation
  Researchers mimic pulmonary edema in Lung-on-a-Chip
  The Wyss Institute’s human breathing lung-on-a-chip, made using human lung and blood vessel cells, acts much like a lung in a human body. A vacuum re-creates the way the lungs physically expand and contract during breathing. As reported in Science Translational Medicine on November 7, 2012, Wyss researchers have now mimicked a human disease –...