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Video/AnimationReimagine the World – Volume 4 – ReConstruct EditionDenise Skok, a two-time breast cancer survivor, Luba Perry, a scientist at the Wyss Institute, and Samuel Lin, a plastic surgeon collaborating with the Wyss Institute, are all working to reimagine a world where breast cancer patients have better reconstruction options. The ReConstruct project at the Wyss Institute uses adipose tissue assembled from a patient’s... -
Video/AnimationReConstruct – 3D Bioprinted Vascularized Fat Tissues for Breast ReconstructionBreast cancer affects 15% of all women. Current options for breast reconstruction are insufficient and have poor patient outcomes. A research team at the Wyss Institute is addressing this clinical need by fabricating vascularized adipose tissue flaps for therapeutic use. Credit: Wyss Institute at Harvard University -
Video/AnimationBridging science, engineering, and art: from mechanobiology to Human Organs-on-ChipsIn this Marsilius Lecture, Wyss Founding Director Don Ingber shares his personal path from a serendipitous experience in an undergraduate art class that led to his discovery of how living cells are constructed using “tensegrity” architecture and how this contributed to the birth of the field of Mechanobiology to his more recent work on human... -
Video/AnimationReimagine the World: Volume 1Four Wyss Institute scientists, Mariana Garcia-Corral, Pawan Jolly, Megan Sperry, and Mike Super, share how they would Reimagine the World and the personal stories that fuel their passion for the work they are doing. We’d love to hear how you would Reimagine the World! Please visit the following link to share your ideas: https://wyss.typeform.com/to/o9xM7cG1 Credit:... -
Video/AnimationSomaCode: GPS for Cell TherapyJust like zip codes help drivers navigate to specific addresses using a GPS system, the molecular ‘zip codes’ identified via the SomaCode platform can be used to deliver cell therapies to their specific targets in the human body, increasing the therapies’ efficacy and reducing side effects. Credit: Wyss Institute at Harvard University -
Video/Animation2021 Kabiller Prize in Nanoscience and NanomedicineDavid R. Walt, a Wyss Core Faculty member, member of the faculty at Harvard Medical School in the Department of Pathology, and a Howard Hughes Medical Institute Professor, is the winner of the 2021 Kabiller Prize in Nanoscience and Nanomedicine, the world’s largest monetary award for outstanding achievement in the field of nanotechnology and its... -
Audio/PodcastDisruptive: 3D BioprintingThere are roughly 120,000 people in the United States on waiting lists for live-saving organ transplants, with only about 30,000 transplants happening every year. To address this great challenge of organ shortages, a team at the Wyss Institute led by Core Faculty member Jennifer Lewis, Sc.D., is developing a method for 3D bioprinting organ tissues... -
Video/AnimationA Swifter Way Towards 3D-printed Organs20 people die waiting for an organ transplant every day in the US, but lab-grown organs so far lack the cellular density and functions required to make them viable replacements. The new SWIFT method from the Wyss Institute and Harvard SEAS solves those problems by 3D printing vascular channel networks directly into living tissue constructs,... -
Video/AnimationKidney Organiods: Flow-Enhanced Vascularization and Maturation In VitroThis video explains how the collaborative project created vascularized kidney organoids and how they advance the field of tissue engineering. Credit: Wyss Institute at Harvard University. -
Video/AnimationScience Nation: Engineering soft robots for paradigm shift in rehabilitationThis video was produced by the National Science Foundation: Tim Gatautis suffered a spinal cord injury in a swimming accident nearly a decade ago and he’s had to use a wheelchair ever since. Gatautis would like to be able to do more for himself, which brings him to the Wyss Institute and the Biodesign Lab... -
Video/AnimationTEDx Beacon Street Salon: Reversing Human AgingWyss Institute Core Faculty member George Church, Ph.D., was the opening speaker at the TEDx Beacon Street saloon event hosted at the Franklin Park Zoo. He presented from inside the tapir cage! Talk summary: Animals can be an extremely useful resource in prolonging human lives and promoting general health. For example, there are organs in... -
Video/AnimationToehold Exchange ProbesThis animation explains how toehold probes consisting of a “probe strand” and a “protector strand” are assembled and how they leverage thermodynamic principles to allow the specific detection of a correct target sequence, or to prevent them from detecting a spurious target sequence that can differ from the correct target sequence by only a single... -
Video/AnimationSoft Exosuit: Human-in-the-Loop Bayesian OptimizationResearchers from the Wyss Institute and Harvard SEAS have developed a human-in-the-loop Bayesian optimization method to personalize the hip assistance that a soft exosuit can provide. The optimized assistance helps reduce metabolic cost compared to walking without the device, or with the device not further personalized. Credit: Harvard Biodesign Lab/Harvard Agile Robotics Lab Learn more... -
Video/AnimationNew Wyss Institute Initiative – 3D Organ EngineeringWyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development. -
Audio/PodcastHow 3D Bioprinting Could Revolutionize Organ ReplacementHow 3D Bioprinting Could Revolutionize Organ Replacement was originally broadcast on WBUR on November 22, 2017. This story features Wyss Core Faculty member Jennifer Lewis. The original broadcast story can be found here. -
Audio/PodcastFormer DI Hoopster Searches For Athletic Boost In The MicrobiomeFormer DI Hoopster Searches For Athletic Boost In The Microbiome was originally broadcast on WBUR’s Only a Game on August 4, 2017. The story features Wyss Core Faculty member George Church and Postdoctoral Fellow Jonathan Scheiman. The original broadcast story can be found here. -
Video/AnimationSoft Exosuit for Post-stroke Gait Re-trainingThis video explains how exosuit technology, developed at the Wyss Institute for Biologically Inspired Engineering, applied to ankle movements helps patients post-stroke regain a more normal gait. Credit: Wyss Institute at Harvard University -
Video/AnimationPodocyte Cells: Kidney-on-a-ChipThis video shows a 3-dimensional rendering of the glomerulus-on-a-chip with human stem cell-derived mature podocytes (in green) grown and differentiated in one channel (shown on top) and that extend their processes through the modeled glomerulus basement membrane towards glomerular vascular cells (in magenta) in the parallel running channel (shown on the bottom). Credit: Wyss Institute... -
Audio/PodcastDavid and Mary Mooney: Seeing Is Believing-Therapeutic Cancer VaccinesWyss Core Faculty member David Mooney presents a talk with Mary Mooney, titled Seeing Is Believing: Therapeutic Cancer Vaccines. Marshalling a patient’s immune system to recognize and destroy cancerous cells is an exciting strategy to attack cancer, and this talk will explore materials that engage the immune system through science and artistic representation. Mary K.... -
Audio/PodcastDisruptive: Sports GenomicsWith 100 trillion cells in the human body, bacteria outnumber our own human cells 2 to 1. These bacteria make up one’s microbiome, and particularly bacteria in our guts affect all our key organ functions. They play a role in our health, development and wellness, including endurance, recovery and mental aptitude. In this episode of... -
Video/AnimationProject ABBIEProject ABBIE is inspired by the story of Abbie Benford, who succumbed to complications related to anaphylaxis just eight days before her 16th birthday. The Wyss Institute, in collaboration with Boston Children’s Hospital, is developing a wearable, non-invasive device that could sense anaphylaxis and automatically inject epinephrine in individuals who are unable to do so... -
Video/Animation3D Printed Heart-on-a-ChipIn this video, learn how Wyss Institute and Harvard SEAS researchers have created a 3D-printed heart-on-a-chip that could lead to new customizable devices for short-term and long-term in vitro testing. Credit: Johan U. Lind (Disease Biophysics Group), Alex D. Valentine and Lori K. Sanders (Lewis Lab)/Harvard University -
Video/AnimationSmoking Human Lung Small Airway-on-a-ChipIn this video, Wyss Founding Director Donald Ingber and Technology Development Fellow Kambez Benam explain how the integrated smoking device mimics normal cigarette smoke exposure and how it can impact research into the causes of COPD and into new biomarkers and therapeutics. Credit: Wyss Institute at Harvard University -
Audio/PodcastDisruptive: Mechanotherapeutics – From Drugs to WearablesMechanobiology reveals insights into how the body’s physical forces and mechanics impact development, physiological health, and prevention and treatment of disease. The emerging field of Mechanotherapeutics leverages these insights towards the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways... -
Audio/PodcastDisruptive: Fluorescent In Situ SequencingDeveloped at the Wyss, FISSEQ (fluorescent in situ sequencing) is a spatial gene sequencing technology that reads and visualizes the three-dimensional coordinates of RNA and mRNAs – the working copies of genes – within whole cells and tissues. FISSEQ affords insights into biological complexity that until now have not been possible. In this episode of... -
Video/AnimationMechanotherapeutics: From Drugs to WearablesThe Wyss Institute’s 7th annual international symposium focused on advances in the field of Mechanobiology that have resulted in the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways as a core part of their mechanism of action. Organized by... -
Audio/PodcastThe Modest Mouse: Why We Use Mice in MedicineThe Modest Mouse: Why We Use Mice in Medicine was originally broadcast on NPR’s Innovation Hub on July 2016. This story features Wyss Core Faculty member Don Ingber. The original broadcast story can be found here. -
Audio/PodcastFireside Chat with George ChurchAudio recording of a fireside chat with Wyss Core Faculty member George Church at the 2016 Convergence Forum, held in Chatham, Mass. on May 12 and 13, 2016. Moderated by Alison Taunton-Rigby. -
Video/AnimationPrinting Vascular TissuePrinting vessel vasculature is essential for sustaining functional living tissues. Until now, bioengineers have had difficulty building thick tissues, lacking a method to embed vascular networks. A 3D bioprinting method invented at the Wyss Institute and Harvard SEAS embeds a grid of vasculature into thick tissue laden with human stem cells and connective matrix. Printed... -
Audio/PodcastGeorge Church: Responsibility, art & science of intentional extinction, de-extinction & agingGeorge Church Responsibility, art & science of intentional extinction, de-extinction & aging Wednesday, Feb 17, 2016 ArtScience @ Le Lab Lecture Series: Art, Design, Engineering & Biology – Core Faculty from the Wyss Institute for Biologically Inspired Engineering at Harvard University discuss how the arts and design are informing the frontiers of science. ArtScience @... -
Audio/PodcastScience, Your Body, And TestingIn 2015 the London Design Museum announced it’s “Design of the Year” award, and for the first time it went to a Medical design. The Wyss Institute for Biologically Inspired Engineering at Harvard University’s “Organs-on-chips” was the overall winner. The chips mimic the functions of human organs for the purpose of medical testing. This broadcast... -
Audio/PodcastDisruptive: Synthetic BiologyWhat sorts of breakthroughs are possible by modifying an organism’s genome – something researchers are now able to do ever more cheaply and efficiently? Researchers around the world are already able to program microbes to treat waste water, generate electricity, manufacture jet fuel, create hemoglobin, and fabricate new drugs. What sounds like science fiction to... -
Video/AnimationSoft Robotic GloveThe soft robotic glove under development at the Wyss Institute could one day be an assistive device used for grasping objects, which could help patients suffering from muscular dystrophy, amyotrophic lateral sclerosis (ALS), incomplete spinal cord injury, or other hand impairments to regain some daily independence and control of their environment. This research is partially... -
Video/AnimationCas9: As a Transcriptional ActivatorIn this technical animation, Wyss Institute researchers instruct how they engineered a Cas9 protein to create a powerful and robust tool for activating gene expression. The novel method enables Cas9 to switch a gene from off to on and has the potential to precisely induce on-command expression of any of the countless genes in the... -
Video/AnimationHuman Organs-On-ChipsWyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer... -
Video/AnimationGene Editing Mechanism of CRISPR-Cas9In this animation, learn how CRISPR-Cas9 gene editing technology can be used to precisely disrupt and modify specific genes. Credit: Wyss Institute at Harvard University. -
Video/AnimationSoft Robotic ExosuitIn this video, Harvard faculty member Conor Walsh and members of his team explain how the biologically inspired Soft Exosuit targets enhancing the mobility of healthy individuals and restoring the mobility of those with physical disabilities. This research is partially funded by the National Science Foundation. Note: This technology is currently in the research and... -
Audio/PodcastCyborg Microchip MedicineThis edition of Revolutions focuses on Cyborg Microchip Medicine. Dr Don Ingber, Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University is visiting Melbourne University and discussed this revolutionary research with Jon Faine. -
Video/AnimationBone Marrow-on-a-ChipWyss Institute Founding Director Don Ingber, Postdoctoral Fellow Yu-suke Torisawa, and Researcher Catherine Spina explain how and why a they built bone marrow-on-a-chip, and how they got it to act like whole living marrow and manufacture blood cells. Credit: Wyss Institute at Harvard University -
Audio/PodcastBuilding Organs, On One Microchip At A TimeBuilding Organs, On One Microchip At A Time was originally broadcast on NPR on July 29, 2012. This story features Wyss Core Faculty member Don Ingber. Original broadcast story can be found here. -
Audio/PodcastBuilding an Organ on a ChipProduced for MIT Technology Review by Kyanna Sutton and Susan Young, this audio segement features Wyss Institute Core Faculty member Don Ingber speaking about how cells grown on the Wyss Institute’s organ-on-chip devices behave more like cells in the body. The devices could improve the speed and success of drug discovery and reduce animal testing.... -
Video/AnimationVibrating Mattress: Preventing Infant ApneaWhat if we could prevent infant apnea? Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Organs-on-a-ChipWhat if we could test drugs without animal models? Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each...