113 Results for 'Polymer Chemistry'
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Tough Gel Adhesives for Wound Healing
A Band-Aid® adhesive bandage is an effective treatment for stopping external bleeding from skin wounds, but an equally viable option for internal bleeding does not yet exist. Surgical glues are often used inside the body instead of traditional wound closure techniques like stitches, staples, and clips because they reduce the patient’s time in the hospital...
Bone Marrow-Like Scaffolds for Accelerating Immune Reconstitution
An implantable bone marrow cryogel to accelerate the full reconstitution of the immune system, including T cell immunity, in patients that received chemotherapy and a bone marrow transplant. This could provide an off-the-shelf, material-based solution for patients with severe blood disorders whose immunity is recovering only slowly after treatment.
Single-Cell Encapsulation for Improved Cell Therapies
The Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system....
Injectable Alginate Hydrogels for Medical Applications
One of the biggest challenges in medicine is getting a drug to the right part of the body at the right time. Even when the target site in the body is known, like a pain-causing injury or a cancerous tumor, most drugs are given as oral pills or intravenous infusions, which limits their effectiveness. In...
Microfluidic Drug Encapsulation
Because of their large molecular sizes and properties, biologic drugs, be it in the form of monoclonal antibodies that target disease-associated molecules or active proteins and enzymes that may correct deficiencies in the human body, have proven difficult to deploy in many cases. Their therapeutic effects on target cells and tissues often require high and...
T Cell Traps
T cells, a subtype of white blood cells, play key roles in cell-mediated immunity, be it to fight infections and cancer or, when corrupted, to react against the body’s own cells in more than 80 autoimmune diseases, including type I diabetes, multiple sclerosis, rheumatoid arthritis and others. However, isolating disease-related T cells from the body...
Video/AnimationJanus Tough Adhesives for Tendon RepairThere is a large unmet need for tendon regeneration therapies after injury. Building upon the tough gel adhesive technologies developed at the Wyss Institute at Harvard University and the Harvard School of Engineering and Applied Sciences, researchers from these institutions collaborated with a group at Novartis to create the Janus Tough Adhesives (JTAs). This two-sided...
Video/AnimationInnovation Showcase – Tough Gel TechnologyJay Sugarman talks with Benjamin Freedman, PhD. Benjamin is a Postdoctoral Fellow at the Wyss Institute for Biologically Inspired Engineering at Harvard University. He’s on Innovation Showcase to inform viewers about the groundbreaking research he and some of his colleagues have been involved with related to the development of the next generation of medical-grade adhesives,...
Video/AnimationSelf-regenerating bacterial hydrogels as intestinal wound patchesThis animation explains how self-regenerating bacterial hydrogels could be used as adhesive patches to help intestinal wounds heal. Credit: Wyss Institute at Harvard University.
Video/AnimationTough Gel AdhesivesInspired by the mucus secreted by the Dusky Arion slug, researchers at the Wyss Institute have developed a surgical adhesive that can adhere to wet and dynamic surfaces inside the body, including the heart, lung, tendons, cartilage, and bone. Coupled with a novel tough hydrogel, which can undergo huge amounts of deformation without breaking, this...
Audio/PodcastDisruptive: Cancer Vaccine and Immuno-MaterialsImmunotherapy – treatment that uses the body’s own immune system to help fight disease – has groundbreaking and life-saving implications. In an effort to make immunotherapy more effective, Wyss Institute researchers are developing new immuno-materials, which help modulate immune cells to treat or diagnose disease. In this episode of Disruptive, Dave Mooney, Wyss Core Faculty...
Video/AnimationFouling Marine FoulingMarine fouling occurs when organisms attach themselves to underwater objects like boats, rope, pipes and building structures. Mussels are one of the biggest culprits. Once attached, they are difficult to remove, leading to operational downtime, increased energy use and damage. Paints and coatings are currently used to prevent marine fouling, but are frequently toxin-based and not...