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Tunable ECMs for more effective T cell therapies

T cell development can be mechanically steered with engineered tissue-mimicking biomaterials adoptive cell therapy manufacturing

Want to collaborate?

The team is seeking collaborations with industry partners to scale the application of tunable ECMs to conditions of therapeutic T cell manufacturing and further investigate their potential as a research tool.



Technology Development Team
Kwasi Adu-Berchie Yutong Liu Favour Obuseh Wei-Hung Jung David Mooney
Key Features
  • Tunable ECMs enhance therapeutic efficacies of adoptively transferred immune cells by mimicking target tissue biomechanics already during manufacturing
  • Biocompatibility and handling conform with current clinical CAR-T manufacturing requirements
  • Easy-to-fabricate collagen-based hydrogels have long-term stability and storability
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