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Technologies 9

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• ReConstruct: Vascularized tissue for breast reconstruction
  ReConstruct is a platform for growing, vascularizing, and implanting patient-derived tissues that enable safer breast reconstruction after cancer surgery.
• Human Ovarian Organoids to Improve Women’s Health
  Gameto is using the Wyss Institute’s fully human ovarian organoid technology to solve the global problem of rising infertility by making IVF safer, cheaper, and more accessible.
• Kidney Engineering Technology for New Tissue Replacement Therapies
  Trestle Biotherapeutics licensed 3D bioprinting, and stem cell and kidney organoid engineering methods to help it create kidney repair and replacement therapies. These could become new standard-of-care options beyond dialysis and kidney transplants for patients with kidney failure.
• Bone Marrow-Like Scaffolds for Accelerating Immune Reconstitution
  An implantable bone marrow cryogel to accelerate the full reconstitution of the immune system, including T cell immunity, in patients that received chemotherapy and a bone marrow transplant. This could provide an off-the-shelf, material-based solution for patients with severe blood disorders whose immunity is recovering only slowly after treatment.
• Engineered Brain Organoids
  The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...
• Focused Rotary Jet Spinning for Heart Implants
  Focused rotary jet spinning (FRJS) is a manufacturing technique that can rapidly spin polymers into long fibers that are easily shaped into heart valves for treating a variety of cardiac diseases in children and adults.

Collaborations 1

• Brain Targeting Program
  Pre-competitive multi-partner industry collaboration that aims to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain.

News 118

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• Awards
  
  Wyss Institute’s CircaVent team awarded grant from BD² to advance research into bipolar disorder and development of more effective drugs
  October 3, 2023
• Press Release
  
  Adding immunity to human kidney-on-a-chip advances cancer drug testing
  August 23, 2023
• Press Release
  
  Wyss Institute promotes Christopher Chen to a Core Faculty member and appoints Ellen Roche and Michael Springer as new members of its Associate Faculty
  July 31, 2023

Multimedia 29

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  Video/Animation
  ReConstruct – 3D Bioprinted Vascularized Fat Tissues for Breast Reconstruction
  Breast cancer affects 15% of all women. Current options for breast reconstruction are insufficient and have poor patient outcomes. A research team at the Wyss Institute is addressing this clinical need by fabricating vascularized adipose tissue flaps for therapeutic use. Credit: Wyss Institute at Harvard University

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  Video/Animation
  The Vagina Chip: A New Preclinical Model for Research on Vaginal Epithelium Microbiome Interactions
  The Vagina Chip allows researchers to study a human model of the vaginal microbiome and develop new treatments for bacterial vaginosis and other conditions that threaten women’s health. Credit: Research Square

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  Video/Animation
  Wyss Institute Brain Targeting Program
  This animation explains how Wyss Institute researchers and their industry partners aim to identify novel transport targets and shuttle compounds to enable more effective delivery of drugs to the brain. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  Interrogator: Human Organ-on-Chips
  This video describes the “Interrogator” instrument that can be programmed to culture up to 10 different Organ Chips and sequentially transfer fluids between their vascular channels to mimic normal human blood flow between the different organs of our body. Its integrated microscope enables the continuous monitoring of the tissues’ integrities in the individual organ chips...

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  Audio/Podcast
  Disruptive: 3D Bioprinting
  There are roughly 120,000 people in the United States on waiting lists for live-saving organ transplants, with only about 30,000 transplants happening every year. To address this great challenge of organ shortages, a team at the Wyss Institute led by Core Faculty member Jennifer Lewis, Sc.D., is developing a method for 3D bioprinting organ tissues...

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  Video/Animation
  A Swifter Way Towards 3D-printed Organs
  20 people die waiting for an organ transplant every day in the US, but lab-grown organs so far lack the cellular density and functions required to make them viable replacements. The new SWIFT method from the Wyss Institute and Harvard SEAS solves those problems by 3D printing vascular channel networks directly into living tissue constructs,...