In the first installment of this two-part episode with Donald Ingber, Founding Director of the Wyss Institute (MA, USA), we discuss his invention of organ-on-a-chip technology, how he is utilizing them in the fight against COVID-19 and the Wyss Institute’s response to the pandemic. Donald touches on the performance of the much-discussed chloroquine in his lung-on-a-chip models. We also discuss the pros and cons of organ-on-a-chip technology verses organoids, exploring their use in combination, before Donald examines the possible replacement of animal models with organ-on-a-chip technology.