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Technologies 41

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• AminoX: Making Better Protein Drugs, Quicker and Cheaper
  AminoX enables protein drugs to only become active in the tumor microenvironment and not elsewhere in the body to avoid immune-related adverse effects in the body. By designing and building non-standard amino acids into strategic positions of protein drugs, AminoX provides tumor-specific, and longer-lasting target inhibition.
• Ichor: Reversing Aging
  Ichor is addressing multiple age-related diseases by identifying genetic interventions that reprogram old cells to a younger state. Therapies based on these interventions could improve survival for cancer patients and long-term cardiovascular and neurological health.
• AquaPulse: Portable Off-the-Grid Water Purification
  Globally, more than 2 billion people are forced to use a drinking water source that is contaminated with bacteria, parasites, and other pathogens, and an estimated 502,000 people die each year from diarrhea as a result of unsafe water. While a majority of the world has access to improved water sources, many are often contaminated;...
• Immunostimulatory RNA Therapeutic for Treatment of Cancer and Infectious Disease
  Our novel dsRNAs stimulate the immune system to inhibit cancer, bacterial, and viral infections including SARS-CoV-2 and multiple influenza strains.
• eRapid: Multiplexed Electrochemical Sensors for Fast, Accurate, Portable Diagnostics
  Handheld electrochemical sensors have revolutionized at-home medical testing for diabetics, but they have not yet been successfully applied to diagnosing other conditions. These sensors are based on the activity of an enzyme, and there are only a limited number of enzymes that can be used to detect biomarkers of human disease. An alternative, much more...
• Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications
  Passive directional valves enable smaller and more complex microfluidics applications across of broad spectrum of future technologies, including diagnostics, drug development, and tissue engineering.

Collaborations 3

• Brain Shuttle Research Sponsorship & Licensing
  Enabling brain-targeted drug development through non-exclusive licensing and pre-competitive research sponsorship.
• Kraft Heinz Partnership
  The Kraft Heinz company approached the Wyss Institute for help to achieve its ambitious goal to make its food products healthier, resulting in a novel technology that is ripe for commercialization.
• Wyss Brain Targeting Program
  Advancing brain delivery approaches that enable more safe and effective brain-targeted therapeutics.

News 207

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• Press Release
  
  Alzheimer’s drug may someday help save lives by inducing a state of “suspended animation”
  August 22, 2024
• Awards
  
  Wyss Institute Research Collaboration Awarded ARPA-H Agreement to Develop Disease-Agnostic Immunotherapeutic RNA Platform
  July 15, 2024
• Translation News
  
  Plastic Degradation Company, Breaking, Emerges from Stealth with Naturally-Derived Solution to Degrade Multiple Plastics with $10.5M in Seed Funding
  April 17, 2024

Multimedia 54

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  Video/Animation
  AminoX: Making Better Protein Drugs, Quicker and Cheaper
  A synthetic biology and advanced chemistry platform that efficiently incorporates non-standard amino acids by hacking the ubiquitous protein synthesis process. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Mice Don’t Menstruate: Reimagining Women’s Health Using Organ Chips with Dr. Donald Ingber
  In this episode, host Sharon Kedar, Co-Founder of Northpond Ventures, is joined by Dr. Donald Ingber, Founding Director at Wyss Institute for Biologically Inspired Engineering at Harvard University. Dr. Ingber’s commitment to following his passion has led him to countless medical and technological breakthroughs, including Organ Chip technology. These incredible chips recreate the structure and...

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  Video/Animation
  What is the future of Engineering with Bioengineering Pioneer Donald E Ingber – Museum of Science
  Is biological inspiration the key to the future of engineering? Bioethicist Insoo Hyun sits down with Donald E. Ingber, Founding Director of the Wyss Institute for Biologically Inspired Engineering and Professor of Bioengineering at Harvard’s School of Engineering & Applied Sciences. Together they explore the profound impact of Nature on engineering beyond the realms of...

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  Video/Animation
  Wyss Institute: Past, Present, Future
  Prior to the Wyss Institute’s founding in 2009, a working group at Harvard University assembled envision the future of biomedical engineering. Now in 2023, we see the how this foundation led to successful technologies positively impacting human and planet health. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Bridging science, engineering, and art: from mechanobiology to Human Organs-on-Chips
  In this Marsilius Lecture, Wyss Founding Director Don Ingber shares his personal path from a serendipitous experience in an undergraduate art class that led to his discovery of how living cells are constructed using “tensegrity” architecture and how this contributed to the birth of the field of Mechanobiology to his more recent work on human...

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  Video/Animation
  Novel Model Organisms w/ Don Ingber & Hans Clevers – BIOS Roundtable
  Don Ingber – Founding Director at Wyss Institute Hans Clevers – Head of Pharma Research & Development (pRED) at Roche Hear about the evolution of humanized models and their potential applications in drug development, personalized medicine, and more. Ingber and Clevers share their scientific experiences and expertise. They also discuss misconceptions surrounding the application of...

Events 18

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• Jun 22, 2023,
  11:00am - 12:00pm
  Webinar
  
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  Ask Me Anything Session: Body-on-a-Chip
  Body-on-a-Chip technology is reshaping drug discovery, disease research, and personalized medicine. Please join a one-of-a-kind Ask Me Anything (AMA) session with the visionary behind it all: Donald Ingber. Prof. Ingber will be there, live, to answer YOUR questions and unveil the untapped potential of this groundbreaking technology. This is your chance to be part of... Free and open to public
• Mar 30, 2022,
  1:00pm - 2:00pm
  Wyss Event
  
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  Enabling Organotypic Differentiae in hPSC-derived Endothelial Cells
  Endothelial cells (ECs) are a heterogeneous and ductile cell type that serves as a critical interface between blood and diverse tissue microenvironments. ECs can adopt brain organotypic properties in response to their interaction a complex ecosystem of cells: adjacent mural smooth muscle cells and pericytes, perivascular immune cells, and surrounding astrocytes that differ across brain... Free and open to public
• Mar 3, 2021,
  11:00am - 3:00pm
  Lecture
  
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  Human Biology: An Exploration of Organs-on-Chips
  Biologic drugs comprise 40 percent of the current drug development pipeline. Existing in vitro and animal models are limited in their ability to evaluate the safety and efficacy of these drugs in humans. These limitations often result in development delays and increased costs. Organs-on-chips emulate human biology by providing a micro-engineered environment lined with living... Free and open to public