Peng is a Professor in the Department of Systems Biology at Harvard Medical School. Peng’s lab uses synthetic DNA/RNA to construct, manipulate, and visualize nanoscale structures. They have developed a general framework to program DNA/RNA strands to self-assemble into structures with user-specified geometry or dynamics. By interfacing these nanostructures with other functional entities (e.g. fluorophores, proteins, inorganics, living cells), they have introduced digital programmability into diverse application areas, e.g. fabrication of inorganic nanoparticles with user-prescribed shapes, robust DNA/RNA probes with near optimal binding specificity for detecting single-base genetic changes, RNA-based synthetic regulators with unprecedented dynamic range and orthogonality for complex programming of protein translation in living cells and on paper-based systems, and highly multiplexed (10+), precisely quantitative (90%+ precision), ultra-high resolution (< 5 nm) super-resolution imaging using DNA-PAINT.
Peng Yin, Ph.D.