Technology Area: Biomarker

Technologies 11

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• NeoSense: Sepsis Detection in Newborns
  NeoSense is a new test that uses a tiny sample of saliva instead of blood, powered by advanced single-molecule detection and AI.
• COPDx: Rapid diagnostic to triage acute exacerbations
  A point-of-care test based on new biomarkers to rapidly identify COPD patients who are high risk of acute exacerbations (AEs), determine the cause, and guide treatment.
• Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease Diagnostics
  This nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers.
• Extracellular Vesicles for Biomarker Detection
  A non-invasive method to identify biomarkers of disease across cell types and develop diagnostics and monitoring systems.
• directEsense: Revolutionizing Animal Diagnostic Testing at the Point-of-Care
  Electrochemical biosensors using a novel surface chemistry offer new opportunities for portable diagnostics with the potential to detect many disease biomarkers in animals and beyond.
• SPEAR: Ultrasensitive Protein Detection in Small Samples
  Spear Bio uses a DNA nanotechnology-driven approach developed at the Wyss Institute that allows the sensitive detection of protein biomarkers in small samples using standard instruments to create new research and diagnostic assays. An ultra-sensitive assay detecting neutralizing antibodies against SARS-CoV-2 will be the first to be commercialized.

Collaborations 3

• Nucleic Acid Delivery Consortium
  An academic-industry consortium focused on the challenge of delivering nucleic acid-based therapies to specific target organs, tissues, and cells.
• Brigham-Wyss DxA
  The Wyss DxA's clinical partners from Brigham and Women’s Hospital identify the most pressing unmet diagnostic needs, provide access to high-quality patient samples for our Biomarker Discovery Laboratory (BDL) and Brigham-Wyss DxA collaborators, and provide invaluable feedback and guidance on the engineering and validation of cost-effective, sensitive, and specific diagnostic tests.
• Biomarker Discovery Laboratory (BDL)
  Bridging the diagnostic gap from biomarker discovery to market-ready test kits and instruments through cutting-edge technology development and clinical collaboration.

News 55

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• Press Release
  
  Toward reading patients’ brains through extracellular vesicles in blood and CSF
  October 28, 2026
• Awards
  
  Wyss Awarded ARPA-H Contract to End the Guesswork in Fetal Distress
  September 8, 2026
• Awards
  
  Wyss Institute receives Massachusetts Life Science Center award to advance metabolomics and lipidomics research across Massachusetts ecosystem
  July 22, 2026

Multimedia 6

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  Video/Animation
  Can We Stop Stabbing Babies? – Salivary Diagnostics for Sepsis Screening in the Neonate
  Every day, across the neonatal care unit, babies are being stabbed to collect their blood for sepsis tests. Adding to this dismal situation, diagnostics developed to assess sepsis in blood are very inaccurate, leading to the unnecessary prescription of antibiotics. Researchers at the Wyss Institute and Brigham and Women’s Hospital have created a more accurate...

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  Video/Animation
  Rapid Triage Test for Active Pulmonary Tuberculosis
  There’s a large unmet need for accurate, fast, and inexpensive diagnostics for active tuberculosis (ATB), which claims the lives over a million people per year. A team of researchers from the Wyss Institute for Biologically Inspired Engineering, The Broad Institute of Harvard and MIT, Brigham and Women’s Hospital (BWH), and several other collaborating institutions have...

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  Video/Animation
  Lighting up proteins with Immuno-SABER
  This animation explains how Immuno-SABER uses the Primer Exchange Reaction (PER) to enable the simultaneous visualization of multiple proteins in tissues in different applications. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  SABER-FISH: Enabling the sensitive and multiplexed detection of nucleic acids within thick tissues
  This animation shows how SABER-FISH uses a suite of DNA nanotechnological methods that together enable the sensitive and multiplexed detection of DNA and RNA targets within cells and thick tissues. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Project ABBIE
  Project ABBIE is inspired by the story of Abbie Benford, who succumbed to complications related to anaphylaxis just eight days before her 16th birthday. The Wyss Institute, in collaboration with Boston Children’s Hospital, is developing a wearable, non-invasive device that could sense anaphylaxis and automatically inject epinephrine in individuals who are unable to do so...

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  Video/Animation
  Lung-on-a-Chip
  Combining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. This extended version of the video includes our findings when we mimicked pulmonary edema on the chip. Credit: Wyss Institute at Harvard University