Application Area: Inflammatory Diseases
95 Results for 'Inflammatory Diseases'
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Technologies 9
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Cellular “Backpacks” to Slow Tumor Growth
Macrophages are the body’s multipurpose defense agents, patrolling for pathogens and engulfing cellular debris, foreign substances, microbes, and even cancer cells. But cancerous tumors have evolved an insidious defense mechanism: they can switch arriving macrophages from an anti-cancer state to a pro-cancer state, in which they help promote the tumor’s growth. As a result, attempts... -
eRapid: Multiplexed Electrochemical Sensors for Fast, Accurate, Portable Diagnostics
Handheld electrochemical sensors have revolutionized at-home medical testing for diabetics, but they have not yet been successfully applied to diagnosing other conditions. These sensors are based on the activity of an enzyme, and there are only a limited number of enzymes that can be used to detect biomarkers of human disease. An alternative, much more... -
FcMBL: Broad-Spectrum Pathogen Capture for Infectious Diseases
Microbial infection is the cause of life-threatening cases of sepsis, meningitis and multiple other diseases that are major causes of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of dangerous microbes must be confirmed, and when they are found, they need to be removed,... -
Single-Cell Encapsulation for Improved Cell Therapies
Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system. Efforts to... -
abbieSense: Anaphylaxis Diagnostic
The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately... -
RAPID: Testing for Food Contaminants
Contamination of food by microorganisms such as certain bacteria, viruses and fungi is a constant concern, with even miniscule amounts of certain species posing a risk for foods to become unsafe and spoiled during storage. Current safety and quality tests are often not sensitive enough to detect rare species, and because they first require the...
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Multimedia 19
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Video/AnimationMucus Layer In Vitro on Human Colon ChipUsing Human Organ Chips, researchers at the Wyss Institute were able to generate the mucus layer of the colon in vitro, which has never been done before. In the colon, the mucus layer protects intestinal epithelial cells against inflammatory stimuli such as pathogens, damaged cells, or irritants. The ability to support mucus-producing cells is one... -
Audio/PodcastResearching Biosensors with Dr. Pawan JollyPoint of Care Medical Devices are the future! Pawan Jolly, Ph.D., Senior Staff Scientist at The Wyss Institute for Biologically Inspired Engineering at Harvard University talks with Jonah and Aryan of the Beyond the Books podcast about his research in the biosensor and medical device arena. They ask him about his latest COVID-19 focused project,... -
Video/AnimationeRapid: Bringing Diagnostics HomeSenior Research Scientist, Pawan Jolly, gives an overview of the eRapid Institute Project, a platform of multiplexed electrochemical sensors for fast, accurate, portable diagnostics. Credit: Wyss Institute at Harvard University -
Video/AnimationInterrogator: Human Organ-on-ChipsThis video describes the “Interrogator” instrument that can be programmed to culture up to 10 different Organ Chips and sequentially transfer fluids between their vascular channels to mimic normal human blood flow between the different organs of our body. Its integrated microscope enables the continuous monitoring of the tissues’ integrities in the individual organ chips... -
Video/AnimationeRAPID: a Platform for Portable DiagnosticseRapid is an electrochemical sensing platform that uses a novel antifouling coating to enable low-cost, multiplexed detection of a wide range of biomolecules for diagnostics and other applications. Credit: Wyss Institute at Harvard -
Video/AnimationSelf-regenerating bacterial hydrogels as intestinal wound patchesThis animation explains how self-regenerating bacterial hydrogels could be used as adhesive patches to help intestinal wounds heal. Credit: Wyss Institute at Harvard University.