12 Results for 'Autoimmune Diseases'
Cellular “Backpacks” to Slow Tumor Growth
A cell therapy innovation that keep macrophages activated against cancer. Macrophages are like little soldiers in our bodies that help fend off diseases like cancer. Our cellular “backpacks” are disc-shaped nanoparticles that can stick to a macrophage without being engulfed, and release a steady stream of cytokines into their macrophage “hosts” to help them fight against cancer.
Single-Cell Encapsulation for Improved Cell Therapies
The Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system....
Implantable Cancer Vaccine
The implantable cancer vaccine is an aspirin-sized disc that is implanted under the skin and serves as an artificial lymph node, recruiting and training a patient's own immune cells to find and kill their cancer cells. It was validated in a Phase I clinical trial at the Wyss Institute, and is currently being developed by Novartis to treat melanoma.
T Cell Traps
T cells, a subtype of white blood cells, play key roles in cell-mediated immunity, be it to fight infections and cancer or, when corrupted, to react against the body’s own cells in more than 80 autoimmune diseases, including type I diabetes, multiple sclerosis, rheumatoid arthritis and others. However, isolating disease-related T cells from the body...