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Technologies 9

Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More
Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more.
Single-Cell Encapsulation for Improved Cell Therapies
The Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system....
Implantable Cancer Vaccine
The implantable cancer vaccine is an aspirin-sized disc that is implanted under the skin and serves as an artificial lymph node, recruiting and training a patient's own immune cells to find and kill their cancer cells. It was validated in a Phase I clinical trial at the Wyss Institute, and is currently being developed by Novartis to treat melanoma.
T Cell Traps
T cells, a subtype of white blood cells, play key roles in cell-mediated immunity, be it to fight infections and cancer or, when corrupted, to react against the body’s own cells in more than 80 autoimmune diseases, including type I diabetes, multiple sclerosis, rheumatoid arthritis and others. However, isolating disease-related T cells from the body...
Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness that disproportionately affects women, causing severe fatigue, cognitive difficulties, sleeping problems, dizziness, and pain. Currently, no treatment exists for ME/CFS. Our team is creating accurate disease models to study brain activity, with the aim of understanding if ME/CFS is caused by continuous activation of interconnected brain...
Stroma Tx: Safe Pregnancy for IBD Patients
Patients with Inflammatory Bowel Disease (IBD) are advised to achieve remission before pregnancy, in an effort to decrease pregnancy-related intestinal issues, including fibrosis. Yet the exact mechanisms underlying the fluctuation of their symptoms remain unclear and there are no treatments currently available. To close this knowledge gap, we are treating our IBD Organ Chips with...

News 8