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Technologies 2

• Circe: Transforming greenhouse gases into biodegradable products
  Our society is built upon cheap, widely available petrochemicals. Beyond gasoline and other fuels, petrochemicals are primary components of many of the objects in our everyday lives, including clothing, cosmetics, electronics, packaging, paint, floors, cars, and furniture. The vast majority of these products do not biodegrade in the environment and are not recycled, and the...
• Brain-Targeting Shuttles for Drug Delivery and Diagnostics
  In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain. Leveraging the human blood-brain barrier (BBB) Chip technology developed by Ingber’s team, combined with advanced antibody R&D capabilities, the...

News 45

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• Translation News
  
  Rejuvenate Bio launches to help dogs live longer, healthier lives
  February 6, 2020
• Press Release
  
  Wyss Institute researchers demonstrate machine-guided engineering of AAV capsids for gene therapy
  November 28, 2019
• Press Release
  
  Combination gene therapy treats multiple age-related diseases in mice
  November 4, 2019

Events 1

• Apr 6, 2019,
  7:30am - 4:30pm
  Symposium
  
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  New England Science Symposium
  The New England Science Symposium (NESS), established in 2002, provides a forum for postdoctoral fellows; medical, dental and graduate students; post-baccalaureates; college and community college students (particularly for African-American, Hispanic/Latino and American Indian/Alaska Native individuals) to share their biomedical and health-related research activities through oral or poster presentations, to engage in discussions related to career... Free and open to public

Multimedia 7

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  Video/Animation
  Improving Canine Healthspan
  A Wyss Institute technology that can treat multiple age-related diseases is now being developed by Rejuvenate Bio into a treatment for mitral valve disease and other deadly conditions in dogs, with the goal of helping man’s best friend live longer, healthier lives. Credit: Wyss Institute at Harvard University

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  Video/Animation
  AAV Capsid Engineering
  Wyss researchers have created a high-throughput platform to generate an Adeno-associated virus 2 (AAV2) library containing 200,000 variants, each carrying a distinct mutation in the virus capsid protein. Their analysis identified capsid changes that enhanced “homing” potential to specific organs in mice and virus viability, as well as a new protein hidden in the capsid-encoding...

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  Video/Animation
  Lighting up proteins with Immuno-SABER
  This animation explains how Immuno-SABER uses the Primer Exchange Reaction (PER) to enable the simultaneous visualization of multiple proteins in tissues in different applications. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  Engineered Cross-feeding in Bacterial Consortia
  Through engineered amino acid cross-feeding, researchers at the Wyss Institute and Harvard Medical School modified multiple bacterial strains to reverse antagonistic interactions and develop symbiotic relationships, resulting in a more balanced consortium and paving the way for future bacteria-based therapeutics. Credit: Wyss Institute at Harvard University

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  Video/Animation
  SABER-FISH: Enabling the sensitive and multiplexed detection of nucleic acids within thick tissues
  This animation shows how SABER-FISH uses a suite of DNA nanotechnological methods that together enable the sensitive and multiplexed detection of DNA and RNA targets within cells and thick tissues. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Primer Exchange Reaction
  In this video, Jocelyn Kishi illustrates how Primer Exchange Reaction (PER) cascades work to autonomously create programmable long single-stranded DNA molecules. Credit: Wyss Institute at Harvard University.