39 Results for 'Immune System'
Broad-Spectrum RNA Therapeutic for COVID-19 and Influenza
The COVID-19 pandemic has killed more than two million people worldwide and death tolls continue to mount due to the lack of an effective prevention, cure, or widespread vaccine for the disease. Influenza viruses have been even more deadly in the past, and still cause hundreds of thousands of deaths every year. Seasonal flu vaccines...
Cellular “Backpacks” to Slow Tumor Growth
Macrophages are the body’s multipurpose defense agents, patrolling for pathogens and engulfing cellular debris, foreign substances, microbes, and even cancer cells. But cancerous tumors have evolved an insidious defense mechanism: they can switch arriving macrophages from an anti-cancer state to a pro-cancer state, in which they help promote the tumor’s growth. As a result, attempts...
OMNIVAX: Broadly Deployable Infection Vaccine Platform
OMNIVAX is an immuno-material-based vaccine platform technology able to create safe and effective therapeutic and prophylactic vaccines against viral and bacterial threats. Its modular approach enables the rapid creation of vaccines for pathogens using known and unknown antigens. Current approaches include vaccines against some viral diseases.
Bone Marrow-Like Scaffolds for Accelerating Immune Reconstitution
An implantable bone marrow cryogel to accelerate the full reconstitution of the immune system, including T cell immunity, in patients that received chemotherapy and a bone marrow transplant. This could provide an off-the-shelf, material-based solution for patients with severe blood disorders whose immunity is recovering only slowly after treatment.
FcMBL: Broad-Spectrum Pathogen Capture for Infectious Diseases
Microbial infection is the cause of life-threatening cases of sepsis, meningitis and multiple other diseases that are major causes of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of dangerous microbes must be confirmed, and when they are found, they need to be removed,...
Single-Cell Encapsulation for Improved Cell Therapies
Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system. Efforts to...
Nov 10, 2016, 2:00pm - 3:00pmLecture
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The innate immune system plays an important role in host defense. Over 15 years ago, we changed the paradigm of the ischemia/reperfusion injury field by identifying mannose binding lectin (MBL) as the initiator of complement activation in vitro and in vivo. Since that time, we have found that MBL plays an important role in many... Free and open to public
Video/AnimationOMNIVAX: Infection Vaccine PlatformThis video explains how OMNIVAX – an immuno-material-based vaccine technology can be used to rapidly create injectable vaccines against diverse viral and bacterial pathogens, and how the platform is used by the team to develop a vaccine against recurring urinary tract infections (UTIs) in their lead human application. Credit: Wyss Institute at Harvard University.
Video/AnimationHumans of the Wyss – Faculty Edition with Mike LevinOur interview series, “Humans of the Wyss – Faculty Edition,” features Wyss Institute faculty members discussing how they think about their work, the influences that helped shape them as scientists, and their collaborations at the Wyss Institute and beyond. In the second edition of the series, Benjamin Boettner, Wyss Institute Communications team member, talks to...