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Technologies 8

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• Broad-Spectrum RNA Therapeutic for COVID-19 and Influenza
  The COVID-19 pandemic has killed more than two million people worldwide and death tolls continue to mount due to the lack of an effective prevention, cure, or widespread vaccine for the disease. Influenza viruses have been even more deadly in the past, and still cause hundreds of thousands of deaths every year. Seasonal flu vaccines...
• Cellular “Backpacks” to Slow Tumor Growth
  Macrophages are the body’s multipurpose defense agents, patrolling for pathogens and engulfing cellular debris, foreign substances, microbes, and even cancer cells. But cancerous tumors have evolved an insidious defense mechanism: they can switch arriving macrophages from an anti-cancer state to a pro-cancer state, in which they help promote the tumor’s growth. As a result, attempts...
• OMNIVAX: Broadly Deployable Infection Vaccine Platform
  Infectious diseases pose one of the greatest threats to public health, and vaccination campaigns with broad population coverage – arguably the most powerful strategy for preventing, controlling, and treating infectious diseases – have eradicated or significantly reduced the risk of contracting diseases such as smallpox, measles, polio, and tetanus. However, there is a constant need for...
• Bone Marrow-Like Scaffolds for Accelerating Immune Reconstitution
  Bone marrow transplants containing hematopoietic stem cells from an immune-compatible (“allogeneic”) donor can cure patients with otherwise fatal blood disorders including multiple myeloma and leukemias by reconstituting their entire immune systems after chemotherapy. However, following such a “hematopoietic stem cell transplantation” (HSCT), the restoration of T cell immunity – which depends on the production of...
• Single-Cell Encapsulation for Improved Cell Therapies
  Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system. Efforts to...
• abbieSense: Anaphylaxis Diagnostic
  The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately...

News 23

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• Research Spotlights
  
  Harvard “Immuno-engineering to Improve Immunotherapy” (i3) Center at the Wyss Institute awards first grant to Dana-Farber cancer immunologist Eric Smith
  January 21, 2021
• Press Release
  
  Turning the problem of cancer metastasis into an opportunity
  November 16, 2020
• Press Release
  
  A viable vaccine for tough tumors
  November 10, 2020

Events 1

• Nov 10, 2016,
  2:00pm - 3:00pm
  Lecture
  
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  Mannose Binding Lectin and Cardiovascular Dysfunction
  The innate immune system plays an important role in host defense. Over 15 years ago, we changed the paradigm of the ischemia/reperfusion injury field by identifying mannose binding lectin (MBL) as the initiator of complement activation in vitro and in vivo. Since that time, we have found that MBL plays an important role in many... Free and open to public

Multimedia 2

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  Video/Animation
  OMNIVAX: Infection Vaccine Platform
  This video explains how OMNIVAX – an immuno-material-based vaccine technology can be used to rapidly create injectable vaccines against diverse viral and bacterial pathogens, and how the platform is used by the team to develop a vaccine against recurring urinary tract infections (UTIs) in their lead human application. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  Humans of the Wyss – Faculty Edition with Mike Levin
  Our interview series, “Humans of the Wyss – Faculty Edition,” features Wyss Institute faculty members discussing how they think about their work, the influences that helped shape them as scientists, and their collaborations at the Wyss Institute and beyond. In the second edition of the series, Benjamin Boettner, Wyss Institute Communications team member, talks to...