71 Results for 'Immune System'
AminoX: Making Biologics Safer with Synthetic Biology and Advanced Chemistry
AminoX enables protein drugs to only become active in the tumor microenvironment and not elsewhere in the body to avoid immune-related adverse effects in the body. By designing and building non-standard amino acids into strategic positions of protein drugs, AminoX provides tumor-specific, and longer-lasting target inhibition.
Metabolically Labeled CAR-T Cells Against Cancer
Through a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to treatment of solid tumors and improve blood cancer therapies.
SomaCode: Getting Cell Therapies Where They Need to Go
SomaCode is solving the problem of cell therapy delivery by identifying unique molecular “zip codes” for disease and engineering cells to home to those zip codes, making cell therapies safer and more effective.
Immunostimulatory RNA Therapeutic for Treatment of Infectious Disease and Cancer
Our novel dsRNAs stimulate the immune system to inhibit cancer, bacterial, and viral infections including SARS-CoV-2 and multiple influenza strains.
Cellular “Backpacks” to Slow Tumor Growth
A cell therapy innovation that keep macrophages activated against cancer. Macrophages are like little soldiers in our bodies that help fend off diseases like cancer. Our cellular “backpacks” are disc-shaped nanoparticles that can stick to a macrophage without being engulfed, and release a steady stream of cytokines into their macrophage “hosts” to help them fight against cancer.
OMNIVAX: Broadly Deployable Infection Vaccine Platform
OMNIVAX is an immuno-material-based vaccine platform technology able to create safe and effective therapeutic and prophylactic vaccines against viral and bacterial threats. Its modular approach enables the rapid creation of vaccines for pathogens using known and unknown antigens. Current approaches include vaccines against some viral diseases.
Video/AnimationMetabolic T cell Labeling: simple and effective enhancement of therapeutic T cells with immune-stimulating cytokinesThis animation shows how the surface of patient-derived T cells is metabolically labeled with azido-sugar molecules that then can be used to attach immune-enhancing cytokines with the help of click chemistry. The approach could help expand adoptive T cell therapies to treatment of solid tumors. Credit: Wyss Institute at Harvard University
Video/AnimationLight-Seq: Light-Directed In Situ Barcoding of BiomoleculesThis animation explains how the Light-Seq technology works to barcode and deep-sequence selected cell populations in tissue samples, and how the team applied it to the analysis of distinct and rare cells in the mouse retina. Credit: Wyss Institute at Harvard University.
Audio/PodcastIlluminating Biological Context with Josie Kishi – Translation by Fifty YearsTechnologies like next-generation sequencing allow us to understand which RNA transcripts and proteins are expressed in biological tissues. However, it’s often equally important to understand how cells or molecules are positioned relative to one another! Whether it be a cell changing its shape, an organelle ramping up a metabolic process, or a DNA molecule traveling...
Video/AnimationSomaCode: GPS for Cell TherapyJust like zip codes help drivers navigate to specific addresses using a GPS system, the molecular ‘zip codes’ identified via the SomaCode platform can be used to deliver cell therapies to their specific targets in the human body, increasing the therapies’ efficacy and reducing side effects. Credit: Wyss Institute at Harvard University
Audio/PodcastOf Mice and Massage with Dr. Bo Ri SeoYou know those people who say you can’t change tissue? Well Wyss Postdoctoral Fellow Bo Ri Seo explains otherwise on this episode of BodyTalk. She is the lead writer on an exciting paper. Dr. Bo Ri Seo is a biomedical engineer who has been studying mechanobiology and mechanotherapy to develop therapeutic strategies for cancer and...
Video/AnimationOMNIVAX: Infection Vaccine PlatformThis video explains how OMNIVAX – an immuno-material-based vaccine technology can be used to rapidly create injectable vaccines against diverse viral and bacterial pathogens, and how the platform is used by the team to develop a vaccine against recurring urinary tract infections (UTIs) in their lead human application. Credit: Wyss Institute at Harvard University.
Nov 10, 2016, 2:00pm - 3:00pmLecture
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The innate immune system plays an important role in host defense. Over 15 years ago, we changed the paradigm of the ischemia/reperfusion injury field by identifying mannose binding lectin (MBL) as the initiator of complement activation in vitro and in vivo. Since that time, we have found that MBL plays an important role in many... Free and open to public