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Technologies 10

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• SomaCode: Getting Cell Therapies Where They Need to Go
  SomaCode is solving the problem of cell therapy delivery by identifying unique molecular “zip codes” for disease and engineering cells to home to those zip codes, making cell therapies safer and more effective.
• Broad-Spectrum RNA Therapeutic for Treatment of COVID-19 and Influenza
  Our novel dsRNAs stimulate the immune system to inhibit many respiratory infections, including SARS-CoV-2, related SARS viruses, and multiple influenza strains.
• Cellular “Backpacks” to Slow Tumor Growth
  Macrophages are the body’s multipurpose defense agents, patrolling for pathogens and engulfing cellular debris, foreign substances, microbes, and even cancer cells. But cancerous tumors have evolved an insidious defense mechanism: they can switch arriving macrophages from an anti-cancer state to a pro-cancer state, in which they help promote the tumor’s growth. As a result, attempts...
• OMNIVAX: Broadly Deployable Infection Vaccine Platform
  OMNIVAX is an immuno-material-based vaccine platform technology able to create safe and effective therapeutic and prophylactic vaccines against viral and bacterial threats. Its modular approach enables the rapid creation of vaccines for pathogens using known and unknown antigens. Current approaches include vaccines against some viral diseases.
• Bone Marrow-Like Scaffolds for Accelerating Immune Reconstitution
  An implantable bone marrow cryogel to accelerate the full reconstitution of the immune system, including T cell immunity, in patients that received chemotherapy and a bone marrow transplant. This could provide an off-the-shelf, material-based solution for patients with severe blood disorders whose immunity is recovering only slowly after treatment.
• FcMBL: Broad-Spectrum Pathogen Capture for Infectious Disease Diagnosis and Therapy
  The Problem Infectious diseases have plagued humanity for millennia, and the pathogens that infect and sicken humans are constantly evolving. Severe infections can cause sepsis, a life-threatening condition in which a patient’s immune system overreacts to the infection. The body starts to attack itself, which can lead to tissue damage, organ failure, and death. Sepsis...

Collaborations 1

• i3 Center: Biomaterials to Create T Cell Immunity
  Cancer immunologists and biological engineers are developing new biomaterials-based approaches to develop new anti-cancer immunotherapies for treatment-resistant cancers.

News 42

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• Press Release
  
  Enhanced cancer immunotherapies through cytokine-labeled T cells
  January 10, 2023
• Awards
  
  Elizabeth Carstens and Yang Claire Zeng selected as 3rd recipients of Harvard’s “Immuno-engineering to Improve Immunotherapy” (i3) Center award
  December 14, 2022
• Press Release
  
  Turning the spotlight on cells in tissues so RNA can tell their story
  October 10, 2022

Events 1

• Nov 10, 2016,
  2:00pm - 3:00pm
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  Mannose Binding Lectin and Cardiovascular Dysfunction
  The innate immune system plays an important role in host defense. Over 15 years ago, we changed the paradigm of the ischemia/reperfusion injury field by identifying mannose binding lectin (MBL) as the initiator of complement activation in vitro and in vivo. Since that time, we have found that MBL plays an important role in many... Free and open to public

Multimedia 6

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  Video/Animation
  Light-Seq: Light-Directed In Situ Barcoding of Biomolecules
  This animation explains how the Light-Seq technology works to barcode and deep-sequence selected cell populations in tissue samples, and how the team applied it to the analysis of distinct and rare cells in the mouse retina. Credit: Wyss Institute at Harvard University.

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  Audio/Podcast
  Illuminating Biological Context with Josie Kishi – Translation by Fifty Years
  Technologies like next-generation sequencing allow us to understand which RNA transcripts and proteins are expressed in biological tissues. However, it’s often equally important to understand how cells or molecules are positioned relative to one another! Whether it be a cell changing its shape, an organelle ramping up a metabolic process, or a DNA molecule traveling...

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  Video/Animation
  SomaCode: GPS for Cell Therapy
  Just like zip codes help drivers navigate to specific addresses using a GPS system, the molecular ‘zip codes’ identified via the SomaCode platform can be used to deliver cell therapies to their specific targets in the human body, increasing the therapies’ efficacy and reducing side effects. Credit: Wyss Institute at Harvard University

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  Audio/Podcast
  Of Mice and Massage with Dr. Bo Ri Seo
  You know those people who say you can’t change tissue? Well Wyss Postdoctoral Fellow Bo Ri Seo explains otherwise on this episode of BodyTalk.  She is the lead writer on an exciting paper. Dr. Bo Ri Seo is a biomedical engineer who has been studying mechanobiology and mechanotherapy to develop therapeutic strategies for cancer and...

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  Video/Animation
  OMNIVAX: Infection Vaccine Platform
  This video explains how OMNIVAX – an immuno-material-based vaccine technology can be used to rapidly create injectable vaccines against diverse viral and bacterial pathogens, and how the platform is used by the team to develop a vaccine against recurring urinary tract infections (UTIs) in their lead human application. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  Humans of the Wyss – Faculty Edition with Mike Levin
  Our interview series, “Humans of the Wyss – Faculty Edition,” features Wyss Institute faculty members discussing how they think about their work, the influences that helped shape them as scientists, and their collaborations at the Wyss Institute and beyond. In the second edition of the series, Benjamin Boettner, Wyss Institute Communications team member, talks to...