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39 Results for 'Inflammation'
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Technologies 6
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Ropirio: Novel Treatments Targeting the Lymphatic System
Ropirio is commercializing the world’s first drug that directly targets and reactivates lymph vessels, a portfolio of other lymph-targeting small molecules, and a preclinical platform for discovering more. -
Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More
Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more. -
Single-Cell Encapsulation for Improved Cell Therapies
The Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system.... -
Vagina-Brain Axis: Treating Hormone Imbalance-Related Diseases
Microbes in our gut have been shown to impact the brain, which is the control center for most of the body’s functions. Research shows that the gut microbiome affects our mood and mental health, including depression. This regulation is called the gut-brain axis. Other organs beyond the gut — including those in the female genital... -
Advancing Mammography with Protein-Biomarkers
Currently, about 10% of women who undergo mammograms have a false-positive result, leading to additional tests, including invasive biopsies. We’re developing a blood test to be administered at the time of breast imaging that could reduce the number of women who are encouraged to get biopsies but do not ultimately have breast cancer. Our study... -
IBD ID: Finding Novel Anti-Inflammatory Drugs
Inflammatory Bowel Disease (IBD) disproportionately affects women, who also experience IBD symptoms differently than men. Through research with human Organ Chips, we identified the role of connective tissue in aggravating inflammation in the nearby intestinal cells of IBD patients. We will use this chip technology to enable rapid screening of stromal cells, crucial for understanding...
