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Technologies 5

• Sustained Growth Factor Delivery for Regenerating Tissues
  The Problem Millions of people worldwide suffer from traumatic injuries or health conditions that cause damage to soft tissues including nerves, muscles, and blood vessels. The body can heal some of that damage, but more serious cases like the severing of a nerve or sustained oxygen deprivation can lead to permanent loss of movement or...
• Single-Cell Encapsulation for Improved Cell Therapies
  The Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system....
• Injectable Alginate Hydrogels for Medical Applications
  One of the biggest challenges in medicine is getting a drug to the right part of the body at the right time. Even when the target site in the body is known, like a pain-causing injury or a cancerous tumor, most drugs are given as oral pills or intravenous infusions, which limits their effectiveness. In...
• Microfluidic Drug Encapsulation
  Because of their large molecular sizes and properties, biologic drugs, be it in the form of monoclonal antibodies that target disease-associated molecules or active proteins and enzymes that may correct deficiencies in the human body, have proven difficult to deploy in many cases. Their therapeutic effects on target cells and tissues often require high and...
• Injectable Hydrogels for Better Drug Delivery
  Wyss researchers have developed a new approach to delivering drugs and therapeutic cells using biocompatible and biodegradable hydrogels made of alginate, a naturally occurring polysaccharide from brown algae. Injectable hydrogels could greatly improve clinical ability to provide extended drug release and controlled delivery throughout the body or at targeted local sites.  The method holds promising...

News 11

View all

• Press Release
  
  “Suspended animation” drug could aid organ transplantation and survival from traumatic injury
  September 24, 2024
• Press Release
  
  Wyss Institute team selected by DARPA-SHIELD program to develop first-of-its-kind biologically engineered broad-spectrum antimicrobial therapeutic
  September 16, 2024
• Translation News
  
  Alkem licenses technology from Harvard University, aiming to treat ischemic injury and vascular diseases
  February 10, 2022

Multimedia 4

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  Video/Animation
  Alginate Hydrogel for Angiogenesis
  This video describes how an alginate hydrogel can be used to trigger the formation of new blood vessels at an ischemic site in the body. Credit: Wyss Institute at Harvard University.

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  Video/Animation
  Shear-Thinning Biomaterial: Catheter Injection
  This movie shows the solid state of the shear-thinning biomaterial immediately after release from the catheter into an aqueous solution (00:04). The STB is cohesive and remains as one solid piece throughout the injection process. There is no noticeable dissolution of the STB into the solution, suggesting it is stable immediately after being discharged from...

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  Video/Animation
  Tough Gel
  A team at the Wyss Institute is honing a tough, rubbery hydrogel initially developed at Harvards School of Engineering and Applied Sciences. The gel is 90 percent water, yet it stretches without breaking to more than 20 times its original length and recoils like rubber, the researchers first reported in Nature in 2012. In fact,...

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  Video/Animation
  Introduction to Implantable Cancer Vaccine
  What if we could prevent and treat cancer with a simple vaccine? Credit: Wyss Institute at Harvard University