10 Results for 'Injectable'
Microfluidic encapsulation for subcutaneous delivery of viscous drugs
Antibodies and other biopharmaceuticals have emerged as a powerful new class of drugs for treating diseases that range from rheumatoid arthritis to breast cancer to macular degeneration. However, these large, protein-based molecules cannot be taken orally (the stomach would digest them) and are frequently given at high concentrations. Most are administered intravenously, but that approach...
Ultra-Strong Flexible Biomaterials
Hydrogels are already being developed for use as scaffolds for tissue engineering, vehicles for drug delivery, actuators for optics and fluidics, and models for biological studies of tissue-supporting material called the extracellular matrix. But these water-rich polymer gels are weak; they rupture if stretched just a little, and they break easily compared with resilient biological...
Implantable cancer vaccine
The Wyss Institute’s implantable, biodegradable cancer vaccine leverages immunotherapeutic methods and could one day help overcome melanoma, other cancers, infectious diseases, auto-immune diseases, as well as vaccinate against specific peptides, proteins, or antigens. The implant is a biodegradable polymer scaffold containing growth factors and components of each patient’s tumors. The technology was initially designed to...
Injectable Hydrogels for Better Drug Delivery
Wyss researchers have developed a new approach to delivering drugs and therapeutic cells using biocompatible and biodegradable hydrogels made of alginate, a naturally occurring polysaccharide from brown algae. Injectable hydrogels could greatly improve clinical ability to provide extended drug release and controlled delivery throughout the body or at targeted local sites. The method holds promising...
Video/AnimationShear-Thinning Biomaterial: Catheter InjectionThis movie shows the solid state of the shear-thinning biomaterial immediately after release from the catheter into an aqueous solution (00:04). The STB is cohesive and remains as one solid piece throughout the injection process. There is no noticeable dissolution of the STB into the solution, suggesting it is stable immediately after being discharged from...
Video/AnimationTough GelA team at the Wyss Institute is honing a tough, rubbery hydrogel initially developed at Harvards School of Engineering and Applied Sciences. The gel is 90 percent water, yet it stretches without breaking to more than 20 times its original length and recoils like rubber, the researchers first reported in Nature in 2012. In fact,...
Video/AnimationIntroduction to Implantable Cancer VaccineWhat if we could prevent and treat cancer with a simple vaccine? Credit: Wyss Institute at Harvard University