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132 Results for 'Microfluidics'
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Technologies 10
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HydroPEF: Portable Off-the-Grid Water Purification
The Problem Globally, more than 2 billion people are forced to use a drinking water source that is contaminated with bacteria, parasites, and other pathogens, and an estimated 502,000 people die each year from diarrhea as a result of unsafe water. While a majority of the world has access to improved water sources, many are... -
Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications
Passive directional valves enable smaller and more complex microfluidics applications across of broad spectrum of future technologies, including diagnostics, drug development, and tissue engineering. -
Origami-Inspired Radiant Cooling for Improved Thermal Health
Origami-inspired Radiant Cooling devices for a broad range of building interiors use microfluidic water-circuits and foldable designs that increase their surface area to achieve more effective cooling. -
Single-Cell Encapsulation for Improved Cell Therapies
The Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system.... -
Liquid-Infused Tympanostomy Tubes
Novel ear tubes coated with proprietary liquid-infused medical-grade polymers that form a frictionless, biofouling-resistant layer inside the tube, dramatically reducing the adhesion of biofluids, human cells, and common ear infection-causing bacterial strains by about 99% when compared with conventional tympanostomy tubes. -
Microfluidic Drug Encapsulation
Because of their large molecular sizes and properties, biologic drugs, be it in the form of monoclonal antibodies that target disease-associated molecules or active proteins and enzymes that may correct deficiencies in the human body, have proven difficult to deploy in many cases. Their therapeutic effects on target cells and tissues often require high and...
News 90
Multimedia 32
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Video/AnimationCutting to the Case: Don IngberDon Ingber, M.D., Ph.D., is the Founding Director of Harvard University’s Wyss Institute for Biologically Inspired Engineering and a pioneer of organ-on-a-chip technology. In this episode of Cutting to the Case, Ingber and host Cameron Sabet discuss how he helped create organs-on-chips, what these systems can teach us that traditional models cannot, and how biologically... -
Video/AnimationAVATARs for Astronaut Health Are Heading to Space!NASA’s AVATAR experiment is flying aboard Artemis II to study how deep space affects human health. Using Organ Chips containing astronaut cells, Emulate and Wyss Institute researchers will examine how radiation and microgravity impact human tissue. This research will help inform medical strategies for future long-duration missions to Mars and beyond. The findings could also... -
Audio/PodcastOrgans on Chips: Using Science, Art, and Design to Understand the Human Body – Talking About BloodIn this episode, Wyss Founding Director Don Ingber, M.D., Ph.D., talks with Helen Osborne about: How organ-on-chip and “human body on chips” technologies are built and how they realistically mimic human organ function by combining living cells, blood flow, and mechanical forces like breathing and stretch; The implications of these chips for hematology and clinical...
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Video/AnimationMice Don’t Menstruate: Reimagining Women’s Health Using Organ Chips with Dr. Donald IngberIn this episode, host Sharon Kedar, Co-Founder of Northpond Ventures, is joined by Dr. Donald Ingber, Founding Director at Wyss Institute for Biologically Inspired Engineering at Harvard University. Dr. Ingber’s commitment to following his passion has led him to countless medical and technological breakthroughs, including Organ Chip technology. These incredible chips recreate the structure and... -
Video/AnimationBridging science, engineering, and art: from mechanobiology to Human Organs-on-ChipsIn this Marsilius Lecture, Wyss Founding Director Don Ingber shares his personal path from a serendipitous experience in an undergraduate art class that led to his discovery of how living cells are constructed using “tensegrity” architecture and how this contributed to the birth of the field of Mechanobiology to his more recent work on human... -
Video/AnimationHow do we make safer and more effective drugs?Wyss researchers are using an ever-growing number of human tissue-mimicking Organ Chips to improve and accelerate the drug development process for a wide number of unmet diseases – and understand what causes them to erupt. More recently, they added a human Vagina Chip and personalized Barrett’s esophagus Chip to their arsenal, and created in vitro...