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Technologies 1

• A broad strategy to reduce the toxicity of protein drugs
  Therapeutic variants of the natural hormone erythropoietin (EPO) which is produced in the kidney to boost the production of red blood cells are commonly used to treat anemias stemming from kidney disease, chemotherapy and other complications. However, many drugs that are based on therapeutic proteins, including EPO, often cause unwanted side effects because they not...

News 33

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• Press Release Programming cells with computer-like logic
  July 26, 2017
• Press Release Remembrance of things past – bacterial memory of gut inflammation
  May 29, 2017
• Press Release Pam Silver elected to the American Academy of Arts and Sciences
  April 13, 2017

Events 1

• Jul 29 → Aug 4, 2017 Conference
  
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  Synthetic Biology Gordon Research Conference and Seminar
  The Synthetic Biology Gordon Research Conference will bring together scientists from biology, chemistry, physics, mathematics and engineering to interact in a stimulating and relaxed environment. In this informal atmosphere, scientists at all stages – graduate students, postdoctoral fellows and established investigators – will have the opportunity to engage in spirited conversations over meals, during session discussions,...

Multimedia 6

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  Video/Animation
  Distributed Cell Division Counter
  Genetically engineered E. coli containing a fluorescing red protein enabled a Wyss Institute and Harvard Medical School team to analyze the population fluctuations of gut microbes by comparing proportion of “marked” to “unmarked” cells. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Circadian Transplant
  The first successful transplant of a circadian rhythm into a naturally non-circadian species could lead to precisely timed release of drugs and other innovative therapeutic applications. In this video, gut bacteria (E. coli) exhibit a circadian rhythm after circadian oscillators were transferred from cyanobacteria. The ‘mother cell’ at the top blinks on and off with...

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  Audio/Podcast
  Disruptive: Synthetic Biology
  What sorts of breakthroughs are possible by modifying an organism’s genome – something researchers are now able to do ever more cheaply and efficiently? Researchers around the world are already able to program microbes to treat waste water, generate electricity, manufacture jet fuel, create hemoglobin, and fabricate new drugs. What sounds like science fiction to...

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  Video/Animation
  Designing Fusion-Protein Therapies
  In this video, watch the new computational model in action as it simulates the behavior of a fusion-protein drug molecule after the targeting protein has attached to a cell. Developed by Wyss researchers, this model helps design more effective biologic drugs while eliminating drug candidates that are prone to causing side effects. Credit: Harvard’s Wyss...

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  Video/Animation
  Magnetic Yeast
  In this video, Wyss Core Faculty member Pamela Silver describes how her team at the Wyss Institute and Harvard Medical School induced magnetic sensitivity in a non-magnetic organism. This technology could potentially be used to magnetize a variety of different cell types in medical, industrial and research applications. Credit: Wyss Institute at Harvard University

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  Audio/Podcast
  Building a Sustainable Future
  In this episode of Harvard Medical LabCast, Harvard Medical School Professor of Systems Biology and Wyss Institute Core Faculty, Pam Silver discusses engineering organisms that produce fuel and even food. Find out how she’s working to build a sustainable future through synthetic biology.