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Technologies 1

• Fusion Proteins for Reduced Drug Toxicity
  Therapeutic variants of the natural hormone erythropoietin (EPO) which is produced in the kidney to boost the production of red blood cells are commonly used to treat anemias stemming from kidney disease, chemotherapy and other complications. However, many drugs that are based on therapeutic proteins, including EPO, often cause unwanted side effects because they not...

News 44

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• Research Spotlights Don’t hate your guts – heal them
  February 10, 2020
• Press Release A reliable clock for your microbiome
  October 11, 2019
• Press Release Helping bacteria be better friends
  August 15, 2019

Events 5

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• Sep 3, 2019 Symposium
  
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  Bridging the Gap Symposium
  The GSAS Harvard Biotechnology Club 20th anniversary symposium will celebrate 20 years of student-driven connections between academia and industry. This meeting will highlight seminal achievements in biotech innovation and commercialization that have occurred since the inception of the club in 1999, especially those which have made a measurable impact on patients’ lives. A theme of...
• Jun 7, 2019, 8:00am - 6:00pm Symposium
  
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  Designing Biology for Health and Sustainability
  Wyss Core Faculty member Pam Silver will be the keynote speaker at the Mid-Atlantic Synthetic Biology Symposium at the University of Virginia. Her talk is entitled, “Designing Biology for Health and Sustainability.” This event is a one-day meeting of the mid-Atlantic Synthetic Biology community.
• Nov 27, 2018, 1:00pm - 2:00pm Lecture
  
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  Designing Biology for Diagnostics and Therapeutics Lecture
  On Tuesday, November 27, join Brigham and Women’s Hospital for the weekly Clinical Pathology Conference lecture series featuring Wyss Core Faculty member Pamela Silver. Pamela Silver is leveraging synthetic biology to build cells that act as sensors, memory devices, and drug delivery agents. Among her recent innovations are bacteria that sense and respond to gut... Free and open to public

Multimedia 8

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  Video/Animation
  Engineered Cross-feeding in Bacterial Consortia
  Through engineered amino acid cross-feeding, researchers at the Wyss Institute and Harvard Medical School modified multiple bacterial strains to reverse antagonistic interactions and develop symbiotic relationships, resulting in a more balanced consortium and paving the way for future bacteria-based therapeutics. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Distributed Cell Division Counter
  Genetically engineered E. coli containing a fluorescing red protein enabled a Wyss Institute and Harvard Medical School team to analyze the population fluctuations of gut microbes by comparing proportion of “marked” to “unmarked” cells. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Gastrointestinal Re-Programming
  In this animation, see an example of how genetically engineered microbes being developed by researchers at the Wyss Institute could detect and treat a wide range of gastrointestinal illnesses and conditions. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Circadian Transplant
  The first successful transplant of a circadian rhythm into a naturally non-circadian species could lead to precisely timed release of drugs and other innovative therapeutic applications. In this video, gut bacteria (E. coli) exhibit a circadian rhythm after circadian oscillators were transferred from cyanobacteria. The ‘mother cell’ at the top blinks on and off with...

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  Audio/Podcast
  Disruptive: Synthetic Biology
  What sorts of breakthroughs are possible by modifying an organism’s genome – something researchers are now able to do ever more cheaply and efficiently? Researchers around the world are already able to program microbes to treat waste water, generate electricity, manufacture jet fuel, create hemoglobin, and fabricate new drugs. What sounds like science fiction to...

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  Video/Animation
  Designing Fusion-Protein Therapies
  In this video, watch the new computational model in action as it simulates the behavior of a fusion-protein drug molecule after the targeting protein has attached to a cell. Developed by Wyss researchers, this model helps design more effective biologic drugs while eliminating drug candidates that are prone to causing side effects. Credit: Harvard’s Wyss...