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Technologies 1

• A broad strategy to reduce the toxicity of protein drugs
  Therapeutic variants of the natural hormone erythropoietin (EPO) which is produced in the kidney to boost the production of red blood cells are commonly used to treat anemias stemming from kidney disease, chemotherapy and other complications. However, many drugs that are based on therapeutic proteins, including EPO, often cause unwanted side effects because they not...

News 38

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• Press Release A telephone for your microbiome
  August 31, 2018
• Research Spotlights Rewiring bacteria for large scale biofuel and bioplastic production
  March 30, 2018
• Community Annihilation: Horizontal Gene Transfer Runs Amok
  March 6, 2018

Events 3

• Nov 27, 2018, 1:00pm - 2:00pm Lecture
  
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  Designing Biology for Diagnostics and Therapeutics Lecture
  On Tuesday, November 27, join Brigham and Women’s Hospital for the weekly Clinical Pathology Conference lecture series featuring Wyss Core Faculty member Pamela Silver. Pamela Silver is leveraging synthetic biology to build cells that act as sensors, memory devices, and drug delivery agents. Among her recent innovations are bacteria that sense and respond to gut... Free and open to public
• May 5 → 6, 2018 Workshop
  
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  Fifth International Mammalian Synthetic Biology Workshop (mSBW 5.0)
  This workshop will explore the latest trends and advances in the field, including recent foundational accomplishments and applications in addressing challenges to human health and beyond.  This one-and-a-half day meeting brings together world’s leading researchers in synthetic biology, mammalian and cellular biology, and bioengineering from academic as well as industry partners. Our scientific program will...
• Jul 29 → Aug 4, 2017 Conference
  
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  Synthetic Biology Gordon Research Conference and Seminar
  The Synthetic Biology Gordon Research Conference will bring together scientists from biology, chemistry, physics, mathematics and engineering to interact in a stimulating and relaxed environment. In this informal atmosphere, scientists at all stages – graduate students, postdoctoral fellows and established investigators – will have the opportunity to engage in spirited conversations over meals, during session discussions,...

Multimedia 7

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  Video/Animation
  Distributed Cell Division Counter
  Genetically engineered E. coli containing a fluorescing red protein enabled a Wyss Institute and Harvard Medical School team to analyze the population fluctuations of gut microbes by comparing proportion of “marked” to “unmarked” cells. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Gastrointestinal Re-Programming
  In this animation, see an example of how genetically engineered microbes being developed by researchers at the Wyss Institute could detect and treat a wide range of gastrointestinal illnesses and conditions. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Circadian Transplant
  The first successful transplant of a circadian rhythm into a naturally non-circadian species could lead to precisely timed release of drugs and other innovative therapeutic applications. In this video, gut bacteria (E. coli) exhibit a circadian rhythm after circadian oscillators were transferred from cyanobacteria. The ‘mother cell’ at the top blinks on and off with...

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  Audio/Podcast
  Disruptive: Synthetic Biology
  What sorts of breakthroughs are possible by modifying an organism’s genome – something researchers are now able to do ever more cheaply and efficiently? Researchers around the world are already able to program microbes to treat waste water, generate electricity, manufacture jet fuel, create hemoglobin, and fabricate new drugs. What sounds like science fiction to...

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  Video/Animation
  Designing Fusion-Protein Therapies
  In this video, watch the new computational model in action as it simulates the behavior of a fusion-protein drug molecule after the targeting protein has attached to a cell. Developed by Wyss researchers, this model helps design more effective biologic drugs while eliminating drug candidates that are prone to causing side effects. Credit: Harvard’s Wyss...

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  Video/Animation
  Magnetic Yeast
  In this video, Wyss Core Faculty member Pamela Silver describes how her team at the Wyss Institute and Harvard Medical School induced magnetic sensitivity in a non-magnetic organism. This technology could potentially be used to magnetize a variety of different cell types in medical, industrial and research applications. Credit: Wyss Institute at Harvard University