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Video/AnimationWhat Is BIOMOD?BIOMOD is a biomolecular design competition for students created by the Wyss Institute for Biologically Inspired Engineering at Harvard University. Each year BIOMOD holds a Jamboree, an annual conference at which all BIOMOD teams convene to present their work from the summer. This year’s Jamboree will take place in Genentech Hall at UCSF in San Francisco,... -
Audio/PodcastDisruptive: Mechanotherapeutics – From Drugs to WearablesMechanobiology reveals insights into how the body’s physical forces and mechanics impact development, physiological health, and prevention and treatment of disease. The emerging field of Mechanotherapeutics leverages these insights towards the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways... -
Audio/PodcastDisruptive: Putting Biofilms to WorkBiofilms are commonly known as the slime-producing bacterial communities sitting on stones in streams, dirty pipes and drains, or dental plaque. However, Wyss Core Faculty member Neel Joshi is putting to work the very properties that make biofilms effective nuisances or threats in our daily lives. In this episode of Disruptive, Joshi and postdoctoral fellow... -
Video/AnimationMechanotherapeutics: From Drugs to WearablesThe Wyss Institute’s 7th annual international symposium focused on advances in the field of Mechanobiology that have resulted in the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways as a core part of their mechanism of action. Organized by... -
Video/AnimationSuper Resolution Discrete Molecular Imaging AnimationSee in this animation, how Discrete Molecular Imaging (DMI) uses DNA nanotechnology to reveal densely packed molecular features in structures similar in size as single protein molecules. Credit: Wyss Institute at Harvard University -
Video/AnimationDiscrete Molecular ImagingWyss Institute Core Faculty member Peng Yin and his co-worker Mingjie Dai explain in this video, how Discrete Molecular Imaging (DMI) can be used to enhance their DNA-PAINT super-resolution imaging platform to visualize features on a single-molecule scale. Credit: Wyss Institute at Harvard University -
Audio/PodcastDisruptive: Molecular RoboticsHow can DNA be programmed to build novel structures, devices, and robots? We have taken our understanding of DNA to another level, beginning to take advantage of some of DNA’s properties that have served nature so well, but in ways nature itself may have never pursued. Humans can now use DNA as a medium for... -
Audio/PodcastDisruptive: Cancer Vaccine & Hydrogel Drug DeliveryIn this episode of Disruptive, Wyss Founding Core Faculty Member Dave Mooney discusses programmable nanomaterials approaches to fighting disease. Mooney explains how a cancer vaccine, developed by his team and currently in a clinical trial at the Dana-Farber Cancer Institute, can train one’s own immune system to target specific cancer cells. He also describes the... -
Video/AnimationDNA NanoswitchesGel electrophoresis, a common laboratory process, sorts DNA or other small proteins by size and shape using electrical currents to move molecules through small pores in gel. The process can be combined with novel DNA nanoswitches, developed by Wyss Associate Faculty member Wesley Wong, to allow for the simple and inexpensive investigation of life’s most... -
Video/AnimationVirus-inspired DNA NanodevicesWyss Institute Core Faculty member William Shih and Technology Development Fellow Steven Perrault explain why DNA nanodevices need protection inside the body, and how a viral-inspired strategy helps protect them. Credit: Wyss Institute at Harvard University -
Video/AnimationTough GelA team at the Wyss Institute is honing a tough, rubbery hydrogel initially developed at Harvards School of Engineering and Applied Sciences. The gel is 90 percent water, yet it stretches without breaking to more than 20 times its original length and recoils like rubber, the researchers first reported in Nature in 2012. In fact,... -
Video/AnimationDNA CagesTo create supersharp images of their cage-shaped DNA polyhedra, the scientists used DNA-PAINT, a microscopy method that uses short strands of DNA (yellow) labeled with a fluorescent chemical (green) to bind and release partner strands on polyhedra corners, causing them to blink. The blinking corners reveal the shape of structures far too small to be... -
Video/AnimationSustainability: The Ultimate ChallengeIn the past century plastic has transformed modern-day life on our planet, but is it sustainable? We produce 300 million tons of plastic per year* and recycle only 3%**. Are we content that the other 97% collects in oceans, landfills and the food chain? The challenge is clear: we will drown in plastic if we... -
Video/AnimationBuilding 3D Structures with DNA BricksThe nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying ‘recipe’ of DNA base pairs. This animation accurately shows how the DNA strands self assemble to build a structure.DNA Nanostructures... -
Video/AnimationDNA Bricks: Molecular AnimationThe nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying “recipe” of DNA base pairs. Animation created by Digizyme for the Wyss Institute. Credit: Wyss Institute at Harvard University -
Video/AnimationMaking Structures with DNA “Building Blocks”Researchers at the Wyss Institute have developed a method for building complex nanostructures out of short synthetic strands of DNA. Called single-stranded tiles (SSTs), these interlocking DNA “building blocks,” akin to Legos, can be programmed to assemble themselves into precisely designed shapes, such as letters and emoticons. Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Implantable Cancer VaccineWhat if we could prevent and treat cancer with a simple vaccine? Credit: Wyss Institute at Harvard University