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Technologies 2

• A broad strategy to reduce the toxicity of protein drugs
  Therapeutic variants of the natural hormone erythropoietin (EPO) which is produced in the kidney to boost the production of red blood cells are commonly used to treat anemias stemming from kidney disease, chemotherapy and other complications. However, many drugs that are based on therapeutic proteins, including EPO, often cause unwanted side effects because they not...
• Pathogen Capture Technology for Infectious Disease Therapeutics and Diagnostics
  Microbial contamination is the cause of life-threatening cases of sepsis, meningitis and multiple other infectious diseases that are a major cause of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of microbial contaminants must be confirmed, and when they are found, they need to...

News 12

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• Press Release ‘Poring over’ DNA
  October 10, 2016
• Press Release How to diagnose systemic infections much more quickly and reliably
  June 14, 2016
• Press Release Designing Better Drugs
  April 15, 2016

Events 1

• May 10, 2017, 1:00pm - 2:00pm Lecture
  
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  Repurposing Nature: Protein Nanocage and Bacterial Cellulose in Medicine and Beyond
  Nature provides us with an abundance of biological materials that we have been repurposing to suit our needs. In this talk, Dr. Lim will highlight two nature-derived materials -protein nanocages and bacterial cellulose- and discuss her team’s work towards engineering, reformatting, and repurposing them for medicine, molecular electronic, and consumer care applications. Free and open to public

Multimedia 4

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  Video/Animation
  Pathogen-Extracting Sepsis Therapy
  This video explains how sepsis induced by an overload of blood pathogens can be treated with the Wyss Institute’s improved pathogen-extracting, spleen-mimicking device. Blood is flown through a cartridge filled with hollow fibers that are coated with a genetically engineered blood protein inspired by a naturally-occurring human molecule called Mannose Binding Lectin (MBL). MBL is...

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  Video/Animation
  Designing Fusion-Protein Therapies
  In this video, watch the new computational model in action as it simulates the behavior of a fusion-protein drug molecule after the targeting protein has attached to a cell. Developed by Wyss researchers, this model helps design more effective biologic drugs while eliminating drug candidates that are prone to causing side effects. Credit: Harvard’s Wyss...

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  Video/Animation
  Bioinspired Approach to Sepsis Therapy
  Wyss Institute Founding Director Don Ingber, Senior Staff Scientist Michael Super and Technology Development Fellow Joo Kang explain how they engineered the Mannose-binding lectin (MBL) protein to bind to a wide range of sepsis-causing pathogens and then safely remove the pathogens from the bloodstream using a novel microfluidic spleen-like device. Credit: Wyss Institute at Harvard...

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  Video/Animation
  Introduction to Sepsis Diagnostic
  What if we could diagnose sepsis in just hours, not days? Wyss Institute researchers discuss their approach to a rapid sepsis diagnostic. Credit: Wyss Institute at Harvard University