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Publications

Publications from our faculty. In order to find a specific publication, use the search box below to search by author, title, journal or date.

December 20, 2023
Nature
Discovery of a structural class of antibiotics with explainable deep learning

Felix Wong, Erica J. Zheng, Jacqueline A. Valeri, Nina M. Donghia, Melis N. Anahtar, Satotaka Omori, Alicia Li, Andres Cubillos-Ruiz, Aarti Krishnan, Wengong Jin, Abigail L. Manson, Jens Friedrichs, Ralf Helbig, Behnoush Hajian, Dawid K. Fiejtek, Florence F. Wagner, Holly H. Soutter, Ashlee M. Earl, Jonathan M. Stokes, Lars D. Renner & James J. Collins
December 14, 2023
eBioMedicine
Direct therapeutic effect of sulfadoxine-pyrimethamine on nutritional deficiency-induced enteric dysfunction in a human Intestine Chip

Seongmin Kim, Arash Naziripour, Pranav Prabhala, Viktor Horváth, Abidemi Junaid, David T. Breault, Girija Goyal, Donald E. Ingber
December 14, 2023
Journal of the American Chemical Society
Mapping Single-Molecule Protein Complexes in 3D with DNA Nanoswitch Calipers

Prakash Shrestha, Darren Yang, Andrew Ward, William M. Shih, and Wesley P. Wong
December 8, 2023
Systems Biology
Optical Estimation of Bioelectric Patterns in Living Embryos

Patrick McMillen, Michael Levin
November 4, 2023
iScience
Information integration during bioelectric regulation of morphogenesis of the embryonic frog brain

Santosh Manicka, Vaibhav P Pai, Michael Levin
November 30, 2023
Advanced Science
Motile Living Biobots Self-Construct from Adult Human Somatic Progenitor Seed Cells

Gizem Gumuskaya, Pranjal Srivastava, Ben G. Cooper, Hannah Lesser, Ben Semegran, Simon Garnier, Michael Levin
November 20, 2023
PLoS One
Differential vascular endothelial cell toxicity of established and novel BCR-ABL tyrosine kinase inhibitors

Yihua Wang, Richard J. Travers, Alanna Farrell, Qing Lu, Jennifer L. Bays,Alec Stepanian, Christopher Chen, Iris Z. Jaffe
November 27, 2023
Nature Immunology
A second-generation M1-polarized CAR macrophage with antitumor efficacy

Anhua Lei, Hua Yu, Shan Lu, Hengxing Lu, Xizhong Ding, Tianyu Tan, Hailing Zhang, Mengmeng Zhu, Lin Tian, Xudong Wang, Siyu Su, Dixuan Xue, Shaolong Zhang, Wei Zhao, Yuge Chen, Wanrun Xie, Li Zhang, Yuqing Zhu, Jing Zhao, Wenhong Jiang, George Church, Francis Ka-Ming Chan, Zhihua Gao & Jin Zhang
November 29, 2023
Science Advances
Synthetic genetic circuits to uncover the OCT4 trajectories of successful reprogramming of human fibroblasts

Katherine Ilia, Nika Shakiba, Trevor Bingham, Ross D Jones, Michael M Kaminski, Eliezer Aravera, Simone Bruno, Sebastian Palacios, Ron Weiss, James J Collins, Domitilla Del Vecchio, Thorsten M Schlaeger
November 15, 2023
Cell Chemical Biology
Discovery of antibiotics that selectively kill metabolically dormant bacteria

Erica J Zheng, Jacqueline A Valeri, Ian W Andrews, Aarti Krishnan, Parijat Bandyopadhyay, Melis N Anahtar, Alice Herneisen, Fabian Schulte, Brooke Linnehan, Felix Wong, Jonathan M Stokes, Lars D Renner, Sebastian Lourido, James J Collins
October 6, 2023
Applied Physics Reviews
Dynamics of macrophage tumor infiltration

Kolade Adebowale; Jennifer L Guerriero; Samir Mitragotri
November 14, 2023
eNeuro
The Multiple Realizability of Sentience in Living Systems and Beyond

Nicolas Rouleau and Michael Levin
November 8, 2023
Molecular Psychiatry
Impaired neural stress resistance and loss of REST in bipolar disorder

Katharina Meyer, King-Hwa Ling, Pei-Ling Yeo, Angeliki Spathopoulou, Derek Drake, Jaejoon Choi, Liviu Aron, Mariana Garcia-Corral, Tak Ko, Eunjung Alice Lee, Jenny M. Tam, Roy H. Perlis, George M. Church, Li-Huei Tsai & Bruce A. Yankner
October 9, 2023
PNAS Nexus
A biomimetic chip to assess subcutaneous bioavailability of monoclonal antibodies in humans

Vineeth Chandran Suja, Qin M Qi, Kevin Halloran, Jifeng Zhang, Suyog Shaha, Supriya Prakash, Ninad Kumbhojkar, Antoine Deslandes, Sylvain Huille, Yatin R Gokarn, Samir Mitragotri
October 31, 2023
ACS Applied Matter Interfaces
High-Throughput Screening of Thiol-ene Click Chemistries for Bone Adhesive Polymers

Kavya Ganabady, Nicola Contessi Negrini, Jacob C. Scherba, Brandon M. Nitschke, Morgan R. Alexander, Kyle H. Vining, Melissa A. Grunlan, David J. Mooney, and Adam D. Celiz
October 20, 2023
Biofabrication
Biomimetic human skin model patterned with rete ridges

Maxwell B Nagarajan, Alexander J Ainscough, Daniel S Reynolds, Sebastien G M Uzel, Jason W Bjork, Bryan A Baker, Amy K McNulty, Susan L Woulfe, Jennifer A Lewis
September 19, 2023
Physics of Life Reviews
Cancer’s unique bioelectric properties: From cells to body-wide networks: Comment on: “The distinguishing electrical properties of cancer cells” by Elisabetta Di Gregorio, Simone Israel, Michael Staelens, Gabriella Tankel, Karthik Shankar, and Jack A. Tuszynski (this issue)

J Mathews, M Levin
October 16, 2023
Nature Communications
A human lung alveolus-on-a-chip model of acute radiation-induced lung injury

Queeny Dasgupta, Amanda Jiang, Amy M. Wen, Robert J. Mannix, Yuncheng Man, Sean Hall, Emilia Javorsky & Donald E. Ingber
September 12, 2023
Cancer Discovery
Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker

Martin S. Taylor; Connie Wu ; Peter C. Fridy; Stephanie J. Zhang ; Yasmeen Senussi; Justina C. Wolters; Tatiana Cajuso; Wen-Chih Cheng; John D. Heaps; Bryant D. Miller; Kei Mori; Limor Cohen; Hua Jiang; Kelly R. Molloy; Brian T. Chait; Michael G. Goggins; Irun Bhan; Joseph W. Franses; Xiaoyu Yang; Mary-Ellen Taplin; Xinan Wang; David C. Christiani; Bruce E. Johnson; Matthew Meyerson; Ravindra Uppaluri; Ann Marie Egloff; Elyssa N. Denault; Laura M. Spring; Tian-Li Wang; Ie-Ming Shih; Jennifer E. Fairman; Euihye Jung; Kshitij S. Arora; Osman H. Yilmaz; Sonia Cohen; Tatyana Sharova; Gary Chi; Bryanna L. Norden; Yuhui Song; Linda T. Nieman; Leontios Pappas; Aparna R. Parikh; Matthew R. Strickland; Ryan B. Corcoran; Tomas Mustelin; George Eng; Omer H. Yilmaz; Ursula A. Matulonis; Steven J. Skates; Bo R. Rueda; Ronny Drapkin; Samuel J. Klempner; Vikram Deshpande; David T. Ting; Michael P. Rout; John LaCava; David R. Walt; Kathleen H. Burns
October 2, 2023
PNAS
A 3D biomimetic model of lymphatics reveals cell-cell junction tightening and lymphedema via a cytokine-induced ROCK2/JAM-A complex

Esak Lee, Siu-Lung Chan, Yang Lee, William J. Polacheck, Sukyoung Kwak, Aiyun Wen, Duc-Huy T. Nguyen, Matthew L. Kutys, Stella Alimperti, Anna M. Kolarzyk, Tae Joon Kwak, Jeroen Eyckmans, Diane R. Bielenberg, Hong Chen, and Christopher S. Chen