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Video/AnimationReConstruct – 3D Bioprinted Vascularized Fat Tissues for Breast ReconstructionBreast cancer affects 15% of all women. Current options for breast reconstruction are insufficient and have poor patient outcomes. A research team at the Wyss Institute is addressing this clinical need by fabricating vascularized adipose tissue flaps for therapeutic use. Credit: Wyss Institute at Harvard University -
Video/AnimationHow can we restore mobility to the sick and injured?Researchers at the Wyss Institute are working to improve treatment outcomes for patients suffering from reduced mobility. This video focuses on two platform technologies that could improve the quality of life for these patients: stochastic resonance and wearable soft robotics. Credit: Wyss Institute at Harvard University -
Video/AnimationReimagining Robots to be Smaller, Softer, and SaferWyss Associate Faculty members, Conor Walsh and Rob Wood, discuss their visions for the future of bio-inspired soft robotics. Credit: Wyss Institute at Harvard University -
Audio/PodcastImmunoengineering with Dave Mooney – BIOS PodcastWyss Core Faculty member Dave Mooney is a leader in the fields of biomaterials, mechanotransduction, drug delivery, tissue engineering and immunoengineering. He is interested in understanding how cells sense signals in their environment and how this alters cell behavior. His laboratory develops biomaterials that exploit these signals to regulate specific cells and their function. They... -
Video/AnimationJanus Tough Adhesives for Tendon RepairThere is a large unmet need for tendon regeneration therapies after injury. Building upon the tough gel adhesive technologies developed at the Wyss Institute at Harvard University and the Harvard School of Engineering and Applied Sciences, researchers from these institutions collaborated with a group at Novartis to create the Janus Tough Adhesives (JTAs). This two-sided... -
Video/AnimationSoft Robots Aiding the Elderly and People with Physical ImpairmentsAn interdisciplinary team at Harvard University School of Engineering and the Wyss Institute at Harvard University is building soft robots for older adults and people with physical impairments. Examples of these robots are the Assistive Hip Suit and Soft Robotic Glove, both of which have been included in the 2021-2022 Smithsonian Institution exhibit entitled “FUTURES.”... -
Audio/PodcastOf Mice and Massage with Dr. Bo Ri SeoYou know those people who say you can’t change tissue? Well Wyss Postdoctoral Fellow Bo Ri Seo explains otherwise on this episode of BodyTalk. She is the lead writer on an exciting paper. Dr. Bo Ri Seo is a biomedical engineer who has been studying mechanobiology and mechanotherapy to develop therapeutic strategies for cancer and... -
Video/AnimationInnovation Showcase – Tough Gel TechnologyJay Sugarman talks with Benjamin Freedman, PhD. Benjamin is a Postdoctoral Fellow at the Wyss Institute for Biologically Inspired Engineering at Harvard University. He’s on Innovation Showcase to inform viewers about the groundbreaking research he and some of his colleagues have been involved with related to the development of the next generation of medical-grade adhesives,... -
Video/AnimationBeating Back the Coronavirus – Nasal swabsEarly in the COVID-19 pandemic, Nasopharyngeal swabs or nasal swabs, used to collect mucus samples to test for the SARS-CoV-2 virus, were in short supply. This created a bottleneck in diagnostics, hampering our ability to control the pandemic. To respond to this need, an interdisciplinary team at the Wyss Institute and Harvard Medical School collaborated... -
Audio/PodcastResearching Biosensors with Dr. Pawan JollyPoint of Care Medical Devices are the future! Pawan Jolly, Ph.D., Senior Staff Scientist at The Wyss Institute for Biologically Inspired Engineering at Harvard University talks with Jonah and Aryan of the Beyond the Books podcast about his research in the biosensor and medical device arena. They ask him about his latest COVID-19 focused project,... -
Video/AnimationPhonoGraft: Programming the eardrum to repair itselfEardrum perforations are a widespread problem affecting millions worldwide. Current standard of care is invasive, involves harvesting an autologous tissue to patch the eardrum, and often requires to revision surgeries, while hearing outcomes remain unsatisfying. What if we could program the eardrum to repair itself after injury? Researchers at the Wyss Institute, Massachusetts Eye and... -
Video/AnimationA Laser Steering Device for Robot-Assisted SurgeryResponding to an unmet need for a robotic surgical device that is flexible enough to access hard to reach areas of the G.I. tract while causing minimal peripheral tissue damage, Researchers at the Wyss Institute and Harvard SEAS have developed a laser steering device that has the potential to improve surgical outcomes for patients. Credit:... -
Video/AnimationOrigami Miniature Surgical ManipulatorResearchers from the Wyss Institute, Harvard SEAS, and Sony have created the mini-RCM, a small surgical robot that can help surgeons perform delicate teleoperated procedures on the human body. Credit: Wyss Institute at Harvard University -
Video/AnimationSmart Thermally Actuating TextilesSmart Thermally Actuating Textiles (STATs) are tightly-sealed pouches that are able to change shape or maintain their pressure even in environments in which the exterior temperature or airflow fluctuates. This soft robotics technology could be developed as novel components of rehabilitation therapies or to prevent tissue damage in hospital bed or wheelchair-bound individuals. Credit: Wyss... -
Video/AnimationBeating Back the Coronavirus: Face Shields for Frontline Healthcare WorkersThere is a national shortage of personal protective equipment (PPE) for frontline healthcare workers battling the COVID-19 pandemic. Researchers from the Jennifer Lewis Lab at the Harvard School of Engineering and Applied Sciences and Wyss Institute at Harvard University self-assembled into a team manufacturing greatly needed face shields for local hospitals. Credit: Wyss Institute at... -
Video/AnimationeRapid: Bringing Diagnostics HomeSenior Research Scientist, Pawan Jolly, gives an overview of the eRapid Institute Project, a platform of multiplexed electrochemical sensors for fast, accurate, portable diagnostics. Credit: Wyss Institute at Harvard University -
Video/AnimationThe Human Mind and Gait ControlResearchers study how our brains adjust to changes in our walking strides, gaining insights that could be used to develop better physical rehabilitation programs. Credit: Wyss Institute -
Video/AnimationeRAPID: a Platform for Portable DiagnosticseRapid is an electrochemical sensing platform that uses a novel antifouling coating to enable low-cost, multiplexed detection of a wide range of biomolecules for diagnostics and other applications. Credit: Wyss Institute at Harvard -
Video/AnimationOrigami OrgansA multidisciplinary team of scientists, engineers, and architectural designers are developing Origami Organs that could function like artificial kidneys. Credit: Wyss Institute at Harvard University -
Audio/PodcastTechnology and Biology brought together in BiomechanicsWearable technology and robotics are two rehabilitation methods used to help those with limited mobility regain movement. Paolo Bonato, PhD, Director of the Motion Analysis Laboratory at Spaulding Rehabilitation Hospital and Wyss Institute Associate Faculty member, discusses the role of innovative technology in rehabilitation in this ThinkResearch episode from the Harvard Catalyst. -
Video/AnimationRobert Wood receives Max Planck-Humboldt MedalThis photomatic portrays Robert Wood and his team innovating (soft) robotics research with new approaches. Credit: Max Planck Society -
Video/AnimationabbieSenseabbieSense is a Wyss technology that can detect histamine levels in human body fluids and determine the severity of an allergic reaction, which could help save the lives of patients with severe allergies. Credit: Wyss Institute at Harvard University -
Video/AnimationNanofiber-Reinforced Micro-ActuatorsThis video explains how two fabrication techniques, soft lithography and rotary jet spinning of nanofibers, are combined to create a new type of micro-actuator for the manipulation of small fragile objects in challenging environments. Credit: Wyss Institute at Harvard University -
Video/AnimationMORPH: A new soft material microfabrication processWhat has the ability to move and show its colors, is made only of silicone rubber and manufactured at the millimeter scale? A soft robotic peacock spider. Researchers have combined three different manufacturing techniques to create a novel origami-inspired soft material microfabrication process that goes beyond what existing approaches can achieve at this small scale.... -
Video/AnimationSoft Exosuit: Human-in-the-Loop Bayesian OptimizationResearchers from the Wyss Institute and Harvard SEAS have developed a human-in-the-loop Bayesian optimization method to personalize the hip assistance that a soft exosuit can provide. The optimized assistance helps reduce metabolic cost compared to walking without the device, or with the device not further personalized. Credit: Harvard Biodesign Lab/Harvard Agile Robotics Lab Learn more... -
Video/AnimationTough Gel AdhesivesInspired by the mucus secreted by the Dusky Arion slug, researchers at the Wyss Institute have developed a surgical adhesive that can adhere to wet and dynamic surfaces inside the body, including the heart, lung, tendons, cartilage, and bone. Coupled with a novel tough hydrogel, which can undergo huge amounts of deformation without breaking, this... -
Video/AnimationThe milliDelta RobotDelta Robots are comprised of three articulating arms connected to an output stage. They are extremely precise and agile, and can be used for “pick & place” and 3D Printing. Researchers at the Wyss Institute and Harvard SEAS have developed a millimeter-scale delta robot, the “milliDelta.” Possible applications at this scale include microassembly, micromanipulation, and... -
Audio/PodcastSlug Slime Inspires Scientists To Invent Sticky Surgical GlueSlug Slime Inspires Scientists To Invent Sticky Surgical Glue was originally broadcast on NPR’s All Things Considered on July 27, 2017. This story features Wyss Institute Technology Development Fellow Jianyu Li. The original broadcast story can be found here. -
Video/AnimationSoft Exosuit for Post-stroke Gait Re-trainingThis video explains how exosuit technology, developed at the Wyss Institute for Biologically Inspired Engineering, applied to ankle movements helps patients post-stroke regain a more normal gait. Credit: Wyss Institute at Harvard University -
Video/AnimationSoft Fabric SensorsThis textile-based sensor effectively registers fine motor movements of the human body, taking researchers one step closer to creating soft, wearable robots. Credit: Wyss Institute at Harvard University -
Video/AnimationHow Humans Walk…With RobotsResearchers at the Wyss Institute and Spaulding Rehabilitation Hospital shed light on how humans respond – or do not respond – to forces applied by rehabilitative robots. Credit: Wyss Institute at Harvard University -
Video/AnimationProject ABBIEProject ABBIE is inspired by the story of Abbie Benford, who succumbed to complications related to anaphylaxis just eight days before her 16th birthday. The Wyss Institute, in collaboration with Boston Children’s Hospital, is developing a wearable, non-invasive device that could sense anaphylaxis and automatically inject epinephrine in individuals who are unable to do so... -
Video/AnimationSoft Robotic Heart Sleeve: In VitroReplicating heart pressure and contraction in vitro, the soft robotic heart sleeve with actuators arranged around a fluid-filled sac is able to rhythmically contract to each time pump a defined fluid volume into the attached tubing. Credit: Harvard SEAS -
Video/AnimationShear-Thinning Biomaterial: Catheter InjectionThis movie shows the solid state of the shear-thinning biomaterial immediately after release from the catheter into an aqueous solution (00:04). The STB is cohesive and remains as one solid piece throughout the injection process. There is no noticeable dissolution of the STB into the solution, suggesting it is stable immediately after being discharged from... -
Audio/PodcastDisruptive: Mechanotherapeutics – From Drugs to WearablesMechanobiology reveals insights into how the body’s physical forces and mechanics impact development, physiological health, and prevention and treatment of disease. The emerging field of Mechanotherapeutics leverages these insights towards the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways... -
Video/AnimationMechanotherapeutics: From Drugs to WearablesThe Wyss Institute’s 7th annual international symposium focused on advances in the field of Mechanobiology that have resulted in the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways as a core part of their mechanism of action. Organized by... -
Video/AnimationEfficient Recovery of Stem Cell SheetsSee in this video how an intact sheet of mesenchymal stem cells, stained with a violet dye, can be lifted off the infused polymer substrate in the culture dish using a filter paper and transferred to a new surface. Credit: Wyss Institute at Harvard University -
Video/Animation3D Printing Metal in MidairIn this video, see the laser-assisted method developed by Wyss Core Faculty member Jennifer Lewis that allows metal to be 3D printed in midair. Credit: Lewis Lab / Wyss Institute at Harvard University -
Video/Animation4D Printing: Shapeshifting ArchitecturesA team at the Wyss Institute and Harvard SEAS has developed a new microscale printing method to create transformable objects. These “4D-printed” objects go a step beyond 3D printing to incorporate a fourth dimension: time. The method was inspired by the way plants change shape over time in response to environmental stimuli. This orchid-shaped structure... -
Audio/PodcastDisruptive: Confronting SepsisIn this episode of Disruptive, Wyss Institute Founding Director Don Ingber and Senior Staff Scientist Mike Super discuss how their team developed a new therapeutic device inspired by the human spleen. This blood-cleansing approach can remove sepsis-causing pathogens from circulating blood without ever needing to know their identity. In animal studies, treatment with this device... -
Video/AnimationPathogen-Extracting Sepsis TherapyThis video explains how sepsis induced by an overload of blood pathogens can be treated with the Wyss Institute’s improved pathogen-extracting, spleen-mimicking device. Blood is flown through a cartridge filled with hollow fibers that are coated with a genetically engineered blood protein inspired by a naturally-occurring human molecule called Mannose Binding Lectin (MBL). MBL is... -
Video/Animation3D Printed Soft Jumping RobotUsing a multi-material 3D printer for manufacturing allowed Wyss Institute researchers to fabricate the jumping robot in one uninterrupted job, seamlessly transitioning from rigid core components to a soft exterior in a single print session. It’s first ever robot to be 3D printed with layers of material gradients, making it extremely durable and giving the... -
Video/AnimationBioinspired Robotics: Softer, Smarter, SaferThe Bioinspired Robotics platform at HarvardÍs Wyss Institute for Biologically Inspired Engineering looks into Nature to obtain insights for the development of new robotic components that are smarter, softer, and safer than conventional industrial robots. By looking at natural intelligence, collective behavior, biomechanics, and material properties not found in manmade systems, scientists at the Wyss... -
Video/AnimationSoft Robotic GloveThe soft robotic glove under development at the Wyss Institute could one day be an assistive device used for grasping objects, which could help patients suffering from muscular dystrophy, amyotrophic lateral sclerosis (ALS), incomplete spinal cord injury, or other hand impairments to regain some daily independence and control of their environment. This research is partially... -
Video/AnimationFluid GateIn this video, the fluid-based gating mechanism separates gas and water. The fluid-filled pores system leverages pressurization to control the opening and closing of its liquid gates, making it extremely precise at separating mixed materials. Credit: Wyss Institute at Harvard University -
Video/AnimationToehold SwitchesIn this animation, Wyss Institute Postdoctoral Fellow Alex Green, Ph.D., the lead author of “Toehold Switches: De-Novo-Designed Regulators of Gene Expression”, narrates a step-by-step guide to the mechanism of the synthetic toehold switch gene regulator. Credit: Wyss Institute at Harvard University -
Video/AnimationProgrammable Paper: Advances in Synthetic BiologyWyss Institute scientists discuss the collaborative environment and team effort that led to two breakthroughs in synthetic biology that can either stand alone as distinct advances – or combine forces to create truly tantalizing potentials in diagnostics and gene therapies. Credit: Wyss Institute at Harvard University. -
Video/AnimationBioinspired Blood Repellent CoatingIn this video, Wyss Institute Founding Director Don Ingber, Core Faculty member Joanna Aizenberg, Staff Scientist Dan Leslie and Postdoctoral Fellow Anna Waterhouse explain how a coating they developed using FDA-approved materials could prevent blood clotting in medical devices without the use of blood thinners. Credit: Wyss Institute at Harvard University -
Video/AnimationSoft Robotic ExosuitIn this video, Harvard faculty member Conor Walsh and members of his team explain how the biologically inspired Soft Exosuit targets enhancing the mobility of healthy individuals and restoring the mobility of those with physical disabilities. This research is partially funded by the National Science Foundation. Note: This technology is currently in the research and... -
Video/AnimationBioinspired Approach to Sepsis TherapyWyss Institute Founding Director Don Ingber, Senior Staff Scientist Michael Super and Technology Development Fellow Joo Kang explain how they engineered the Mannose-binding lectin (MBL) protein to bind to a wide range of sepsis-causing pathogens and then safely remove the pathogens from the bloodstream using a novel microfluidic spleen-like device. Credit: Wyss Institute at Harvard... -
Video/AnimationNew coating turns glass into superglassA transparent new coating makes ordinary glass tough, ultraslippery, and self-cleaning. The coating is based on SLIPS — the world’s slipperiest synthetic substance. Here, a droplet of dyed octane quickly beads up and rolls off a watch glass with the new coating. To learn more, go to Credit: Wyss Institute at Harvard University -
Video/AnimationTiny 3D-Printed BatteryIn this video, a 3D-printer nozzle narrower than a human hair lays down a specially formulated “ink” layer by layer to build a microbattery’s anode from the ground up. Unlike ink in an office inkjet printer, which comes out as droplets of liquid and wets a piece of paper, these 3D-printer inks are specially formulated... -
Video/AnimationBuilding 3D Structures with DNA BricksThe nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying ‘recipe’ of DNA base pairs. This animation accurately shows how the DNA strands self assemble to build a structure.DNA Nanostructures... -
Video/AnimationNeuroAssessA team at Harvard’s Wyss Institute and Beth Israel Deaconess have developed a computer tablet application that could rapidly and quantitatively assess neuromuscular performance. Credit: Wyss Institute at Harvard University -
Video/AnimationDNA Bricks: Molecular AnimationThe nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying “recipe” of DNA base pairs. Animation created by Digizyme for the Wyss Institute. Credit: Wyss Institute at Harvard University -
Video/AnimationSLIPS‘SLIPS’ technology, inspired by the slippery pitcher plant that repels almost every type of liquid and solid, is a unique approach to coating industrial and medical surfaces that is based on nano/microstructured porous material infused with a lubricating fluid. By locking in water and other fluids, SLIPS technology creates slick, exceptionally repellent and robust self-cleaning... -
Video/AnimationVibrating Mattress: Preventing Infant ApneaWhat if we could prevent infant apnea? Credit: Wyss Institute at Harvard University -
Video/AnimationSLIPS: Keeping Ice AwayWhat if we could design surfaces that prevent ice formation? ‘SLIPS’ technology, inspired by the slippery pitcher plant that repels almost every type of liquid and solid, is a unique approach to coating industrial and medical surfaces that is based on nano/microstructured porous material infused with a lubricating fluid. By locking in water and other... -
Video/AnimationIntroduction to Sepsis DiagnosticWhat if we could diagnose sepsis in just hours, not days? Wyss Institute researchers discuss their approach to a rapid sepsis diagnostic. Credit: Wyss Institute at Harvard University