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117 Results for 'George Church'
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Technologies 8
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Controlled Enzymatic RNA Oligonucleotide Synthesis
Synthetic RNA oligonucleotides designed as specific successions of the four nucleobases A, U, G, and C that mimic naturally occurring RNA species are the key components of diverse RNA-based therapies. These include RNA therapeutics that can partially or completely turn off the expression of disease-causing genes (antisense and interfering RNAs), help replace or supplement dysfunctional... -
DNA Data Storage
The genetic material DNA has garnered considerable interest as a medium for digital information storage because its density and durability are superior to those of existing silicon-based storage media. For example, DNA is at least 1000-fold more dense than the most compact solid-state hard drive and at least 300-fold more durable than the most stable... -
Synthetic AAV Capsids for Advanced Gene Therapy
The protein shell (capsid) of Adeno-associated viruses (AAV) are presently the most promising delivery vehicles for various in vivo gene therapies. AAVs are non-pathogenic and, through past engineering efforts, have become safe due to their inability to integrate into and damage the genome of target cells. Rather, the delivered DNA containing a therapeutic gene of... -
Engineered Brain Organoids
The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of... -
Gene Drives
Since the 1940s, researchers have thought of using gene drives to eradicate populations of pests and disease vectors, and to reduce or eliminate invasive species that wreak havoc on natural ecosystems. The idea of a gene drive stems from nature itself, where in sexually reproducing organisms a certain version of a gene is preferentially passed... -
Athlete-Derived Probiotics
Elite athletes possess extraordinary physical abilities enabling them to reach peak performances and recover quickly. The question is, can we extract information from their biology and use it to boost the performance level and speed up recovery of every-day-athletes? Research in different laboratories over the past years has discovered potential connections between the composition of...
News 77
Events 9
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Jun 10, 2020, 10:00am - 4:00pmConference
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The Department of Biomedical Informatics invites you to join the 6th annual Precision Medicine conference, which will be held virtually this year. When you seek treatment for a medical disorder and visit a doctor, if she decides to treat you with a medication, the number of options she has may number 5, 10 maybe even 20.... Free and open to public -
Mar 9 → 10, 2020
Conference
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The 2020 Annual Bioethics Conference will explore the potential of biotechnology to drive and shape the future of clinical care and research, and how ethics interacts with biotechnology in medicine, and consider multiple approaches to how we might ensure that biotechnology continues to evolve ethically. The practice of medicine over the course of the last fifty years... -
Nov 14, 2019
Symposium
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The 2019 Symposium of the Consortium for Space Genetics will be dedicated to Earth because, after all, Earth is in Space. Its focus will be climate change and the potential of genetic technologies to halt or reverse it, ameliorate the consequences of it, and prepare the living world for the extreme conditions that will arise because of...
Multimedia 23
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Video/AnimationEnzymatic DNA Synthesis (EDS) for Data StoragePostdoctoral Fellow, Henry Lee, presents a Wyss Institute Validation Project that is developing a sustainable, low-cost approach for writing large amounts of digital information in DNA. This could one day replace current data storage methods, which are energy intensive and use large amounts of nonrenewable resources. Credit: Wyss Institute at Harvard University -
Video/AnimationImproving Canine HealthspanA Wyss Institute technology that can treat multiple age-related diseases is now being developed by Rejuvenate Bio into a treatment for mitral valve disease and other deadly conditions in dogs, with the goal of helping man’s best friend live longer, healthier lives. Credit: Wyss Institute at Harvard University -
Video/AnimationAAV Capsid EngineeringWyss researchers have created a high-throughput platform to generate an Adeno-associated virus 2 (AAV2) library containing 200,000 variants, each carrying a distinct mutation in the virus capsid protein. Their analysis identified capsid changes that enhanced “homing” potential to specific organs in mice and virus viability, as well as a new protein hidden in the capsid-encoding... -
Video/AnimationTEDx Beacon Street Salon: Reversing Human AgingWyss Institute Core Faculty member George Church, Ph.D., was the opening speaker at the TEDx Beacon Street saloon event hosted at the Franklin Park Zoo. He presented from inside the tapir cage! Talk summary: Animals can be an extremely useful resource in prolonging human lives and promoting general health. For example, there are organs in... -
Audio/PodcastFormer DI Hoopster Searches For Athletic Boost In The MicrobiomeFormer DI Hoopster Searches For Athletic Boost In The Microbiome was originally broadcast on WBUR’s Only a Game on August 4, 2017. The story features Wyss Core Faculty member George Church and Postdoctoral Fellow Jonathan Scheiman. The original broadcast story can be found here. -
Video/AnimationCRISPR-Cas: Molecular RecordingIn this video, Wyss Institute and Harvard Medical School researchers George Church and Seth Shipman explain how they engineered a new CRISPR system-based technology that enables the chronological recording of digital information, like that representing still and moving images, in living bacteria. Credit: Wyss Institute at Harvard University