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96 Results for 'George Church'
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Technologies 7
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Synthetic AAV virus capsids for advanced gene therapy
The protein shell (capsid) of Adeno-associated viruses (AAV) are presently the most promising delivery vehicles for various in vivo gene therapies. AAVs are non-pathogenic and, through past engineering efforts, have become safe due to their inability to integrate into and damage the genome of target cells. Rather, the delivered DNA containing a therapeutic gene of... -
Engineering organoids to recapitulate brain tissue
The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of... -
Gene Drives
Since the 1940s, researchers have thought of using gene drives to eradicate populations of pests and disease vectors, and to reduce or eliminate invasive species that wreak havoc on natural ecosystems. The idea of a gene drive stems from nature itself, where in sexually reproducing organisms a certain version of a gene is preferentially passed... -
Sports Genomics
Elite athletes possess extraordinary physical abilities enabling them to reach peak performances and recover quickly. The question is, can we extract information from their biology and use it to boost the performance level and speed up recovery of every-day-athletes? Research in different laboratories over the past years has discovered potential connections between the composition of... -
Fluorescent In Situ Sequencing (FISSEQ)
Working copies of active genes — called messenger RNAs or mRNAs —translate the genetic information present in DNA into proteins within the cells’ multiple compartments. They are often positioned strategically within cells in ways that contribute critically to how cells and tissues grow, develop and function, and their mislocation can lead to disease development. To... -
High Density Information Storage in DNA
A new method developed at the Wyss Institute allows for synthesis of oligonucleotides by the thousands on a single DNA microchip — a collection of thousands of different DNA segments attached to a glass slide or other solid surface. Until now, generating long strands of DNA has been challenging and labor-intensive. Yet Wyss researchers have...
News 64
Events 5
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Sep 21, 2018, 8:15am - 6:15pm
Wyss Event
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The 9th International Wyss Symposium will focus on new advances in the emerging field of Molecular Robotics, with the goal of sharing recent progress at the intersection of DNA nanotechnology, synthetic biology, robotics, and computer science, that could lead to programmable molecular machines as novel solutions for research and medicine. This event is free, however... Free and open to public -
Jun 16, 2018, 5:00pm - 9:00pm
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Join TEDx Beacon Street for their next event hosted at the Franklin Park Zoo. Wyss Founding Core Faculty member George Church will be featured as the opening speaker and he will speak from inside the Tapir cage! Please visit the event website for more details and to purchase tickets. -
May 16 → 19, 2018
Workshop
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Wyss Core Faculty member George Church and Wyss team members Eric Kelsic, Kai Chan and Pierce Ogden will speak about their work on AAV capsid engineering as part of this year’s American Society of Gene and Cell Therapy Annual Meeting. Please visit the ASGCT Annual Meeting website, for more information related to the meeting and...
Multimedia 20
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Video/AnimationTEDx Beacon Street Salon: Reversing Human AgingWyss Institute Core Faculty member George Church, Ph.D., was the opening speaker at the TEDx Beacon Street saloon event hosted at the Franklin Park Zoo. He presented from inside the tapir cage! Talk summary: Animals can be an extremely useful resource in prolonging human lives and promoting general health. For example, there are organs in... -
Audio/PodcastFormer DI Hoopster Searches For Athletic Boost In The MicrobiomeFormer DI Hoopster Searches For Athletic Boost In The Microbiome was originally broadcast on WBUR’s Only a Game on August 4, 2017. The story features Wyss Core Faculty member George Church and Postdoctoral Fellow Jonathan Scheiman. The original broadcast story can be found here. -
Video/AnimationCRISPR-Cas: Molecular RecordingIn this video, Wyss Institute and Harvard Medical School researchers George Church and Seth Shipman explain how they engineered a new CRISPR system-based technology that enables the chronological recording of digital information, like that representing still and moving images, in living bacteria. Credit: Wyss Institute at Harvard University -
Video/AnimationPodocyte Cells: Kidney-on-a-ChipThis video shows a 3-dimensional rendering of the glomerulus-on-a-chip with human stem cell-derived mature podocytes (in green) grown and differentiated in one channel (shown on top) and that extend their processes through the modeled glomerulus basement membrane towards glomerular vascular cells (in magenta) in the parallel running channel (shown on the bottom). Credit: Wyss Institute... -
Audio/PodcastDisruptive: Sports GenomicsWith 100 trillion cells in the human body, bacteria outnumber our own human cells 2 to 1. These bacteria make up one’s microbiome, and particularly bacteria in our guts affect all our key organ functions. They play a role in our health, development and wellness, including endurance, recovery and mental aptitude. In this episode of... -
Video/AnimationWyss Study: Memory GenesResearchers at the Wyss Institute and the Personal Genome Project (PGP) are using Lumosity games to evaluate memory functions and response times. The genomes of high performers will be sequenced, with the goal of uncovering the relationship between genetics, memory, attention, and reaction speed. This video featuring George Church, Core Faculty of the Wyss Institute and Professor...