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AminoX: Making Better Protein Drugs, Quicker and Cheaper
AminoX enables protein drugs to only become active in the tumor microenvironment and not elsewhere in the body to avoid immune-related adverse effects in the body. By designing and building non-standard amino acids into strategic positions of protein drugs, AminoX provides tumor-specific, and longer-lasting target inhibition.
Ichor: Reversing Aging
Ichor is addressing multiple age-related diseases by identifying genetic interventions that reprogram old cells to a younger state. Therapies based on these interventions could improve survival for cancer patients and long-term cardiovascular and neurological health.
Plastivores: Plastic-Degrading Super-Microbes and Enzymes
The Plastic Degradation project identifies microbes from natural sources that have a low-level ability to degrade multiple types of plastic. In the laboratory, with the help of synthetic biology, those microbes then are evolved into much more effective plastic-eating microbes that, in the future, could be globally deployed to decompose plastic waste.
Human Ovarian Organoids to Improve Women’s Health
Gameto is using the Wyss Institute’s fully human ovarian organoid technology to solve the global problem of rising infertility by making IVF safer, cheaper, and more accessible.
eRNA: Enzymatic RNA synthesis for better drugs
EnPlusOne Biosciences is enabling RNA oligonucleotide manufacturing at scale, meeting the increasing demand for RNA drugs with an enzymatic process that is more efficient and creates a smaller environmental footprint.
Sparkle: Instant Biosensors for Real-Time Imaging
Sparkle is revolutionizing the binder assay industry by harnessing novel chemistry to create instant fluorescent biosensors for a wide variety of uses.
HarborSite: Precise and Efficient Gene Editing for Next-Generation Gene Therapies
The HarborSite next-generation gene therapy platform enables integration of therapeutic genes into genomic safe harbors using highly specific and efficient recombinases to enable more predictable, safe and durable gene therapies.
CircaVent: A Drug Discovery Platform for Mental Health Conditions
CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder.
Biotechnology for Conservation and De-Extinction
Colossal Biosciences is leveraging a suite of technologies including genome engineering to de-extinct critical species like the wooly mammoth to advance conservation to combat biodiversity loss.
SomaCode: Getting Cell Therapies Where They Need to Go
SomaCode is solving the problem of cell therapy delivery by identifying unique molecular “zip codes” for disease and engineering cells to home to those zip codes, making cell therapies safer and more effective.
MRBL: Next-Generation Gene Therapy for Molecular Skin Rejuvenation
The next-generation gene therapy for molecular skin rejuvenation combines a comprehensive target gene prediction with a novel transdermal delivery approach for therapeutic adenovirus-associated viruses. The platform targets monogenic disease indications in the skin, and extends the same targets to the treatment of common skin aging conditions.
Multiplexed Protein Binding and Barcoding Platform for Drug Development
Manifold Bio is commercializing an end-to-end drug discovery and development platform to improve the efficiency of protein therapeutic creation.
Athlete-Derived Probiotics
FitBiomics is commercializing probiotic supplements based on unique combinations of microbes found in elite athletes’ guts to help optimize the health and function of all humans.
Synthetic Adeno-Associated Virus (AAV) Capsids for Advanced Gene Therapy
Dyno Therapeutics is aiming to become a leading gene therapy delivery partner for companies in this space, and to enable a new generation of more effective, safer gene therapies by harnessing optimized AAV capsids.
Engineered Pig Organs for Human Transplant
eGenesis is working toward ending the global transplant shortage and transforming the treatment of organ failure by using CRISPR to edit the pig genome to make their organs safe for transplant in human patients.
Engineered Brain Organoids
The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...
Gene Drives
Since the 1940s, researchers have thought of using gene drives to eradicate populations of pests and disease vectors, and to reduce or eliminate invasive species that wreak havoc on natural ecosystems. The idea of a gene drive stems from nature itself, where in sexually reproducing organisms a certain version of a gene is preferentially passed...
FISSEQ: Fluorescent In Situ Sequencing
Working copies of active genes — called messenger RNAs or mRNAs —translate the genetic information present in DNA into proteins within the cells’ multiple compartments. They are often positioned strategically within cells in ways that contribute critically to how cells and tissues grow, develop and function, and their mislocation can lead to disease development. To...
DNA Data Storage
The genetic material DNA has garnered considerable interest as a medium for digital information storage because its density and durability are superior to those of existing silicon-based storage media. For example, DNA is at least 1000-fold more dense than the most compact solid-state hard drive and at least 300-fold more durable than the most stable...
MAGE: Multiplex Automated Genomic Engineering
Developed at the Wyss Institute, the multiplex automated genome engineering (MAGE) technology harnesses the natural principles of evolution to do all the heavy lifting of genome design and automates these steps to dramatically shorten the time scale required to produce microbes with specialized functionalities for manufacturing, sensing and therapeutic applications. Genome engineering has a wide...
Ovarian Modeling for Fertility Treatments
Infertility is a global health problem, affecting nearly every industrialized nation in the world, and an estimated 10% of men and women in the US. Ovarian abnormalities and oogenesis disorders are a leading cause of female infertility, but little is known about their underlying genetic causes due to lack of suitable research models. We’re collaborating...
Vagina-Brain Axis: Treating Hormone Imbalance-Related Diseases
Microbes in our gut have been shown to impact the brain, which is the control center for most of the body’s functions. Research shows that the gut microbiome affects our mood and mental health, including depression. This regulation is called the gut-brain axis. Other organs beyond the gut — including those in the female genital...

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