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156 Results for 'Mechanobiology'
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Technologies 12
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Regenerating heart valves
The human heart beats approximately 35 million times every year, pumping blood into the circulation via four different heart valves. In more than four million people each year, heart valves fail for different reasons, including birth defects, age-related deteriorations and infections. At present, clinicians use either artificial prostheses or fixed animal and cadaver-sourced tissue to... -
Ultra-Strong Flexible Biomaterials
Hydrogels are already being developed for use as scaffolds for tissue engineering, vehicles for drug delivery, actuators for optics and fluidics, and models for biological studies of tissue-supporting material called the extracellular matrix. But these water-rich polymer gels are weak; they rupture if stretched just a little, and they break easily compared with resilient biological... -
Soft Exosuits
Soft exosuits offer a new way to assist the elderly in maintaining or restoring their gait, in rehabilitating children and adults with movement disorders due to Stroke, Multiple Sclerosis and Parkinson’s Disease, or to ease the physical burden of soldiers, firefighters, paramedics, farmers and others whose jobs require them to carry extremely heavy loads.For decades... -
Improving Balance and Gait Control
Balance in humans relies on complex feedback from the senses that govern the body’s mechanical stability. Wyss Institute and Boston University researchers have discovered that random vibrations, too gentle to be felt, can improve the sensory feedback system and may restore stability through a mechanism known as “stochastic resonance”. By incorporating vibrating elements in insoles... -
Preventing Infant Apnea
Clinicians and engineers at the Wyss Institute and the University of Massachusetts Medical School have developed a unique and proprietary system that reduces the onset of neonatal apnea in low birth-weight infants in a clinical trial at Beth Israel Deaconess Medical Center. The system makes use of the concept of Stochastic Resonance to reset the... -
Mechanically-Activated Drug Targeting Nanotechnology
The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...
News 103
Multimedia 41
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Audio/PodcastEngineering birdsongsResearchers at the Wyss Institute at Harvard University and the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a simple device that mimics complex birdsongs. The device, developed by the group of Wyss Core Faculty member L. Mahadevan, Ph.D., uses air blown through a stretched rubber tube to recreate birdsongs... -
Audio/PodcastCyborg Microchip MedicineThis edition of Revolutions focuses on Cyborg Microchip Medicine. Dr Don Ingber, Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University is visiting Melbourne University and discussed this revolutionary research with Jon Faine. -
Video/AnimationEnvironmental Impact: Chitin-Inhibiting Pesticides Called into QuestionChitin, a molecule that serves a purpose in the developmental biology of insects, fungi and shrimp, has long been a target of growth-inhibiting pesticides due to the belief that it did not exist in vertebrates. For decades, chitin-inhibiting pesticides have stunted the growth of insects and fungi to protect valuable crops. Now, research from the... -
Video/AnimationDNA NanoswitchesGel electrophoresis, a common laboratory process, sorts DNA or other small proteins by size and shape using electrical currents to move molecules through small pores in gel. The process can be combined with novel DNA nanoswitches, developed by Wyss Associate Faculty member Wesley Wong, to allow for the simple and inexpensive investigation of life’s most... -
Video/AnimationHuman Organs-On-ChipsWyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer... -
Video/AnimationKilobots: A Thousand-Robot SwarmIn this video, Kilobots self-assemble in a thousand-robot swarm. The algorithm developed by Wyss Institute Core Faculty member Radhika Nagpal that enables the swarm provides a valuable platform for testing future collective Artificial Intelligence (AI) algorithms. Credit: Harvard School of Engineering and Applied Sciences.