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163 Results for 'Mechanobiology'
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Technologies 12
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Soft Wearable Shoulder-Assistive Device
Patients suffering from neuromuscular conditions such as muscular dystrophy, amyotrophic lateral sclerosis (ALS), and incomplete spinal cord injury are, in many cases, confronted with partial or total loss of their shoulder strength and mobility that greatly limit their abilities to perform activities of daily living. In the long term, this is believed to increase their... -
Human Organs-on-Chips
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to... -
Regenerating heart valves
The human heart beats approximately 35 million times every year, pumping blood into the circulation via four different heart valves. In more than four million people each year, heart valves fail for different reasons, including birth defects, age-related deteriorations and infections. At present, clinicians use either artificial prostheses or fixed animal and cadaver-sourced tissue to... -
Improving Balance and Gait Control
Balance in humans relies on complex feedback from the senses that govern the body’s mechanical stability. Wyss Institute and Boston University researchers have discovered that random vibrations, too gentle to be felt, can improve the sensory feedback system and may restore stability through a mechanism known as “stochastic resonance”. By incorporating vibrating elements in insoles... -
Preventing Infant Apnea
Clinicians and engineers at the Wyss Institute and the University of Massachusetts Medical School have developed a unique and proprietary system that reduces the onset of neonatal apnea in low birth-weight infants in a clinical trial at Beth Israel Deaconess Medical Center. The system makes use of the concept of Stochastic Resonance to reset the... -
Mechanically-Activated Drug Targeting Nanotechnology
The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...
News 108
Multimedia 43
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Video/AnimationNew Wyss Institute Initiative – 3D Organ EngineeringWyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development. -
Audio/PodcastDisruptive: Cancer Vaccine and Immuno-MaterialsImmunotherapy – treatment that uses the body’s own immune system to help fight disease – has groundbreaking and life-saving implications. In an effort to make immunotherapy more effective, Wyss Institute researchers are developing new immuno-materials, which help modulate immune cells to treat or diagnose disease. In this episode of Disruptive, Dave Mooney, Wyss Core Faculty... -
Audio/PodcastEngineering birdsongsResearchers at the Wyss Institute at Harvard University and the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have developed a simple device that mimics complex birdsongs. The device, developed by the group of Wyss Core Faculty member L. Mahadevan, Ph.D., uses air blown through a stretched rubber tube to recreate birdsongs... -
Video/AnimationSoft Exosuit for Post-stroke Gait Re-trainingThis video explains how exosuit technology, developed at the Wyss Institute for Biologically Inspired Engineering, applied to ankle movements helps patients post-stroke regain a more normal gait. Credit: Wyss Institute at Harvard University -
Video/AnimationSoft Exosuit for RunningBuilding upon previous soft exosuit technology, researchers at the Wyss Institute and Harvard SEAS have developed a soft exosuit for running. This exosuit applies forces to the hip joint using thin, flexible wires, assisting the muscles during each stride. Using an off-board actuation system, compared to not wearing the exosuit, this exosuit can reduce the... -
Video/AnimationWyss Focus: Immuno-MaterialsWyss Core Faculty, Dave Mooney, explains our new Immuno-Materials Focus Area, which adds a new dimension to immunotherapy in that it harnesses materials to make treatments more efficient and effective. These material-based systems are capable of modulating immune cells and releasing them into the body where they can treat diseases.